**9. Conclusions**

Many studies have identified the potential health risks of ACR and the ambiguity of the mechanisms underlying ACR induced neurotoxicity has gained interest. Current toxicological studies are insufficient to indicate that ACR amounts consumed in the normal diet are likely to result in adverse human health effects. ACR is considered to be a potential health hazard that can impact toxicity to humans. An overview of their occurrence and effects have been comprehended in this review chapter. The importance of oxidative stress, dose and time variations in exposed rat models is being used to comprehend the mechanisms and the neurotoxic effects induced by ACR in rat models. ACR, a toxic neurotoxin is associated with the pathogenesis of various neurodegenerative diseases and their effects on neuronal apoptosis are analysed. Various therapeutic agents against ACR induced neurotoxicity have been analysed to understand their ameliorative effect. This review would give an overall insight on the toxicological effects of acrylamide and provides a comprehensive approach about

the recent findings on how to mitigate the formation of acrylamide by using effective therapeutic strategies. More research at the cellular level will aid in the identification of early biomarkers that can be utilised to detect, avoid or mitigate the effects of ACR induced neurotoxicity.
