**4.1 Dose and time dependent response**

Studies have been made to understand the relation between the dose response and effect of ACR in rats. ACR has shown remarkable toxic effects with acute doses from the very beginning [31]. The response has been found to vary with the dose of exposure. The different doses of ACR to which the rat model has been exposed to be


*Acrylamide: A Neurotoxin and a Hazardous Waste DOI: http://dx.doi.org/10.5772/intechopen.102607*


**Table 1.**

*Dose and time dependent exposure of acrylamide in rats.*

discussed to understand the dose-effect of ACR includes 0.5–50 mg/kg [1, 7, 31–36] (**Table 1**). In rats, the NOAEL for ACR induced neurotoxicity was 0.5 mg/kg body weight/day and the LOAEL was 2 mg/kg-day in F344 male rats for the most sensitive effect (microscopic nerve alterations).
