*2.1.1.1 Cancer*

The ethyl acetate fraction of *P. dactylifera* fruit extract has shown the antifibrotic (expression of fibronectin-1 and alpha-smooth muscle actin) and antiproliferative activity in tumor necrosis factor (TNF) stimulated pancreatic cancer cells *in vitro* [10]. In addition, the ethyl acetate fraction of *P. dactylifera* has shown the anticancer effect against prostate cancer cells [17], ethyl alcohol extract against human hepatocellular carcinoma hepatoma G2 (HepG2) cells and triple-negative mammary carcinoma MDA-MB-231 cells [18, 19] and methanolic extract against human breast adenocarcinoma Michigan Cancer Foundation-7 (MCF-7) cells *in vitro* [20]. In a previous study, an aqueous extract of *P. dactylifera* has shown the anticancer potential in diethylnitrosamine-induced hepatocellular carcinoma in *Wistar* rats [21]. *P. dactylifera* has improved the treatment outcome of pediatric cancer patients clinically [22].
