*2.2.1.2 Cancer*

Methanolic fruit extract of *F. carica* possessed antiproliferative activity against hepatocyte-derived carcinoma cells with an IC50 value >2000 μg/mL [47]. Virtual screening, molecular docking and dynamics simulation investigations were combined to give a structural insight into the putative binding mechanism of prospective drug-like phytocomponents of *F. carica* with crucial molecular targets which play a significant role in the pathogenesis of several cancer. β-Bourbonene was found to show the best binding with topoisomerase-I, topoisomerase-II, and Vascular Endothelial Growth Factor-2 (VEGFR-2), thereby, altering their functions to alter the pathogenesis [48].
