**7.2** *Securinega virosa* **(Roxb ex. Willd) Baill**

*Securinega virosa* is a medicinal plant commonly used in Africa in the management of epilepsy and other mental illnesses. The antipsychotic prospect of the residual aqueous fraction of the plant was assessed by means of the apomorphine induced stereotypic climbing behavior model and the swim induced grooming model, all in mice. The effect of the fraction on haloperidol-induced catalepsy was also assessed. The fraction inhibited the grooming behavior and attenuated the climbing behavior of the mice. These action of *S. virosa* extract was associated to its involvement with the dopamine D1 receptor. Therefore, the study confirmed the antipsychotic potential of *S. virosa* in traditional medicine [66]. The observed effects were ascribed to the presence of alkaloid, saponin, flavonoid and tannin in the leaves.
