*4.4.4.2 Monokine*

Monokine which is induced by interferon-gamma (MIG) is a chemoattractant for activated T cells and also has angiostatic activity [123]. In their study Wakabayashi et al. reported that MIG could play an role in the pathogenesis of DR and works in cooperation of VEGF in the progression of pathological angiogenesis in DR. The authors have detected higher levels of MIG in vitreous of DR patients [123]. Elevated MIG levels are could be in response to the up-regulation of angiogenic factors such as VEGF. The alternative mechanism could be in play in DR which results in chemotaxis of leukocytes rather than in carrying out its angiostatic functions [26].
