**6.3 Hyperreflective material within intraretinal cystoid spaceSolid**

Solid appearing cysts with hyper-reflective material within the cyst have been documented in DME (**Figure 7**) [66]. The content of these cysts has been hypothesized to be fibrin or of inflammatory origin [66]. However, no alteration to response to anti-VEGF treatment was reported [66].

Another novel OCT finding that has been recently reported in a patient with DME is a subretinal pseudocyst [67]. Contrary to what has been earlier documented, a cyst-like appearance was observed in the subretinal space and not within the retinal layers. The migration of Müller cells into the subretinal space has been proposed to be the reason for the development of the pseudocyst in that location [67].
