**6. Conclusion**

Studies carried out both in diabetic patients and experimental animal models of diabetic retina have shown that the diabetic milieu promotes an increased local expression of inflammation. Unlike, uveitis however this inflammation is not clinically apparent and is noted at a molecular level. Critically located between the vasculature and neurons of the retina, Glial cells have a key role in closely regulating the retinal microenvironment. Recent findings implicate that these cells also responsible in the initiation of the inflammatory cascade.

It is possible that inflammation does not perfectly describe all the changes that ultimately occur in diabetic retinopathy, but it does seems to describe the pathogenesis of the retinopathy better than the previous concept of microvasculopathy. It is likely that this concept will become better focused with future research.

### **Author details**

Anuj Sharma\* and Deepesh Arora Retina Services, Amritsar Eye Clinic, Dehradun, India

\*Address all correspondence to: dr.anuj18@gmail.com

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

*Role of Inflammation in Diabetic Retinopathy DOI: http://dx.doi.org/10.5772/intechopen.100175*
