**2. Self nano emulsifying formulations (SNEF)**

SNEF is an isotropic mixture of surfactants, lipids, and solubilizers having great ability to form fine O/W nano-emulsion by mild agitation. It has droplet size 2–200 nm dispersion in water which improves increase the rate of dissolution and bioavailability of PWSDs [6]. SNEF is the most stable emulsion due to the partitioning of the drug between the oil and aqueous phase gives larger interfacial area. It is technically proven that droplet size of nanoemulsions was not affected by the fed and fasted dissolution conditions. Optimized nanoemulsions reduce bioavailability ratio in fed and fasted state which maintain reproducible plasma profile. Optimized formulation improves oral absorption of PWSDs hence the onset of action is quick. Nanoemulsion improves conc. of the drug in systemic circulation (bioavailability) which leads to a reduction of does and higher does related adverse effects in case of potential anticancer drugs [7].
