**11.4 SNEF for TCM**

Silybin protects liver cells from damage of drinking, smoking and liver-damaging drugs. Due to low solubility of silybin in water it has very low bioavailability when given orally. Hence when silybin formulated in SNEF with ethyl linoleate as lipid, Tween and dimethyl isosorbide as surfactant and co-surfactant respectively bioavailability of silybin increased 04 folds.

*Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability… DOI: http://dx.doi.org/10.5772/intechopen.108703*
