**6. SNEF and recent advancements in oral drug delivery**

SNEF is a recent advancement in lipid-based nanoemulsions and it is a promising strategy to solubilize drug molecule in the lipid phase which is biocompatible. SNEF play dual function it protects entrapped drug molecule against degradation in GI fluids also absorption of the drug in lymphatic transport increased. It mainly focused on the impact on the size and surface nature of nanocarriers on targeted uptake by entrecote [19, 20]. **Figure 1** shows an overview of encapsulated SNEF developed for oral administration. SNEF expressed as to potential nanoemulsion which is thermodynamically and kinetically more stable hence it has great ability to enhance oral bioavailability of PWSDs [21]. In 1995 for first-time saquinavir was introduced in the market in salt form having only 4% bioavailability in a hard gelatin capsule. After 02 years bioavailability increased 03 folds in human by formulating in SNEF with medium-chain mono- and diglycerides [22, 23].

#### **Figure 1.** *Enhancement of oral bioavailability through SNEF.*
