*8.2.6 In-vitro drug release*

It is determined using dissolution apparatus to study the release profile and dissolution profile of the tablets. It directly influences the rate of absorption. Since it possesses more than one API, the simultaneous equation method is used to calculate the drug concentration in the sample by UV Visible spectrophotometer [29]. Tablets are dropped into the dissolution medium of 900 ml volume, maintained at 37 ± 0.5 ºC. Based on the requirement Type I or II dissolution apparatus is selected. The paddle/basket is rotated at 25-100 rpm. Samples are withdrawn at a specific time period and evaluated UV spectroscopically.
