**1. Introduction**

In recent years, promising efforts have been made to use the potentials of lipid drug delivery systems for solubility and bioavailability enhancement potential. Poorly watersolubility and bioavailability are major challenge in front of formulation of scientists in development of new formulation. Lipid-based drug delivery systems (LBDDS) have great potential of versatility and biocompatibility. Lipid-based formulations modified in different routes to adapt a broad range of products as per the requirements of disease and route of administration. The key factor of LBDDS is their safety and efficacy during design and development of medicines [1]. Recently LBDDS gained much importance in reducing variable food effects and enhancement of bioavailability of poorly water-soluble active pharmaceutical ingredient (API). LBDDS offers great advantages like controlled and targeted drug delivery, stability of developed formulation which is capable of carrying both lipophilic and hydrophilic drugs within it [2]. Lipid formulations classified in to liquid lipid-based formulations, emulsions or microemulsion, Self-emulsifying drug delivery systems (SEDDS), solid-in-oil (S/O) suspension, solid lipid-based formulations, lipid as particulate drug carriers, liposome, solid lipid nanoparticles (SLNs), neosome. Present work gives an overview of Self nanoemulsifying formulations, its components, future perspectives and applications in commercialization. SNEF is the most promising approach which overcomes poor water solubility; bioavailability and formulation difficulties poorly water-soluble drugs [3]. SNEF designed to increase solubility and bioavailability of drugs belonging to the BCS Class II-IV. SNEF comprehensively enhance the solubility and bioavailability of poorly water soluble drugs (PWSDs) by micelle formation. In SNEF API introduced as nanosized oil droplets. Rapid drug release of SNEF in the stomach due to the generation of nanosized oil droplets leads to the quick onset of action in the GI tract. SNEF easily dispersible due to the partitioning of a drug between oil and water which generates a larger interfacial area. SNEF offers ample of advantages such as reproducible plasma drug conc., decrease in variability of rate and extent of absorption [4]. SNEF holds the drug in a solution that allows enough time for drug absorption through GIT [5].
