**13. Conclusions**

Approximately 40% newly synthesized drug moieties are associated with poor water solubility, low bioavailability, high intra- and inter-subject variability, and a lack of dose proportionality. SNEF is now becoming a promising approach to enhance solubility, dissolution and hence bioavailability of poorly water-soluble drugs. An additional advantage of SNEF over simple oily solutions is that they provide a large interfacial area for the partitioning of the drug between oil and water. Incorporation of a liquid SNEF into a solid dosage form may combine the advantages of SNEF with those of a solid dosage form and overcome the disadvantages of liquid formulations. Conclusively, SNEF would be a promising approach for poorly water soluble drugs to improve its therapeutic interventions.

### **Acknowledgements**

The authors are thankful to Department of Pharmaceutics Sant Gajanan Maharaj College of Pharmacy Mahagaon and Trustees of Sant Gajanan Maharaj College of Pharmacy Mahagaon for providing required guidance and support for completion of this work.
