Preface

Dosage forms, also known as drug delivery systems, are an essential aspect of modern pharmaceutical science. They are the physical forms in which drugs are administered to patients and they play a crucial role in determining the efficacy and safety of a medication. The field of dosage forms is vast and diverse, encompassing everything from traditional solid and liquid forms to newer technologies such as nanoparticles and gene therapy.

This book provides detailed explanations of the various technologies and techniques used to develop dosage forms and examines some of the dosage forms used in modern pharmaceutical science. It also examines progress and highlights recent developments in the field. Furthermore, the book highlights the practical aspects of dosage forms, including their formulation and development.

Chapter 1, 'Layered Tablets: A Novel Oral Solid Dosage Form', highlights the importance of layered tablets and how patient compliance can be improved by reducing the number of tablets administered to patients at one time. Chapter 2, 'Orally Disintegrating Tablets', discusses the production of tablets that have rapid disintegration in the oral cavity. Chapter 3, 'Multifunctional Roles of PVP as a Versatile Biomaterial in Solid State', examines the multifunctional role of Polyvinylpyrrolidone (PVP) in the solid state and demonstrates how PVP made it possible to overcome several challenges in drug formulations, such as solubility and bioavailability weakness, physical instability under stress conditions, and complexation efficiency of cyclodextrin molecules. Chapter 4, 'Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and Future Perspective', provides valuable information on lipid-based lipid-based formulations for increasing the bioavailability of poorly soluble drugs. Chapter 5, 'Novel Topical Drug Delivery Systems in Ophthalmic Applications', examines the progress made in novel dosage forms meant for delivery to the eyes. Chapter 6, 'Interplay between Pharmacokinetics and Pharmacogenomics', provides in-depth information on how an individual's genetic makeup can be the key to creating personalized drugs with greater efficacy and safety. It describes how polymorphism may alter the pharmacokinetic properties of administered drugs. Chapter 7, '*In Vitro* Drug Metabolism Studies Using Human Liver Microsomes', explains why understanding the metabolic stability and kinetics of glucuronidation of an investigational drug is crucial for predicting the pharmacokinetic parameters that support dosing and dose frequency. It provides detailed information about metabolite profiling, metabolic stability, glucuronidation kinetics, reactive metabolites identification, CYP enzyme inhibition, and general protocols using human liver microsomes. Chapter 8, 'Use of Statins in Dental Implantology and Their Impact on Osseointegration: Animal Studies', discusses the relationship between local use of statins and better osseointegration. Finally, Chapter 9, 'Perspective Chapter: Tuberculosis Drugs Doses from Indian Scenario – A Review', presents research on tuberculosis treatment in India in recent years with the goal of providing advice to healthcare providers.

The goal of this book is to provide readers with a solid understanding of the scientific and technological principles that underlie the development of dosage forms. By providing a thorough introduction to the field and its key concepts, the book aims to equip readers with the knowledge and skills needed to understand the latest research and developments in the field as well as to pursue careers in pharmaceutical science or related fields.

Overall, this book is an essential resource for anyone interested in the field of dosage forms, including students, researchers, and practitioners in pharmaceutical science, pharmacy, and medicine. With its detailed explanations and practical examples it provides a comprehensive and accessible introduction to this complex and rapidly evolving field.

> **Usama Ahmad** Faculty of Pharmacy, Department of Pharmaceutics, Integral University, Lucknow, India

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Section 1

Solid Dosage Forms and Role

of Excipients

Section 1
