**4. Pharmacotherapy**

Pharmacotherapy can counteract the increase in appetite the decrease in energy expenditure that occur as an adaptive mechanism to weight loss which, improve adherence to lifestyle modifications. Pharmacotherapy is indicated for BMI ≥30 or BMI ≥27 with obesity-associated conditions [95]. It is prescribed together with comprehensive diet, physical activity and behavioral therapy to achieve adequate WL, and should result in clinically significant WL (≥5% mean TWL%). Anti-obesity medications are prescribed according to their efficacy and safety, the type of obesity associated comorbidities. Several medications are approved for obesity management (**Table 3**).


**Table 3.**

*Pharmacotherapy: anti-obesity medications.*

**146**
