**9. Conclusion**

It may be concluded that leptin is the cross-talk molecule linking human reproduction and nutrition. More than 25 years after its discovery, leptin is now known to mediate a paraphernalia of functions relating to the reproductive capacity. Leptin exerts its actions in several ways at multiple levels of the pathway of reproduction including the hypothalamus, ovary, and the placenta. It plays a crucial role in essential processes in the establishment of a normal pregnancy such as trophoblastic invasion, placentation, and transfer of nutrients to the developing embryo. The pathological significance of leptin in human reproduction may be elucidated by the fact that deregulation of leptin levels is responsible for the genesis of a wide variety

of disorders associated with pregnancy and reproduction including GDM, FGR, PE, PCOS, RPL and infertility. Recombinant leptin therapies and leptin sensitisers should be the ground for further research to address the devastating effects of abnormal leptin levels and leptin resistance on human reproduction.
