**Acknowledgements**

The authors join to thank all the people who made this research possible, from the researchers themselves, to the investors and funds, as well as all the people and institutions who contributed to all the articles cited in the list of references. They all participated to the development of this new solution, directly or indirectly.

Thank you most particularly to Pierre Déchelotte and Sergueï Fetissov who made the discovery of the conformational antigen ClpB and its role in appetite regulation and founded TargEDys to transpose this knowledge into a product and approach to safely help people regulate their hunger and weight.

Thank you to Manon Dominique, Marie Galmiche Nicolas Lucas et Romain Legrand for all their research work in investigating the precise mechanism of action of *H. alvei* and ClpB as Ph.D. students and TargEDys research team.

The authors also thank warmly all TargEDys employees and partners who worked together and enabled the development of processes and production of the strain, from fermentation to blending and encapsulation, all the suppliers who provide highquality delivery systems and packaging, to optimize the protection of the bacteria and protein all the way to the gut as well as the product's stability, and all the regulatory advisers that made it possible to reach the market with this food grade strain that was never used as a probiotic before.
