**3.2 Peripheral appetite stimulating signal**

A. It acts through Gut hormone secrete ghrelin, obestatin. Anorexigenic via ObRb receptor expressed in brain and peripheral tissue which is binding in the hypothalamus, leptin activates a complex neural circuit comprising of anorexigenic (that is appetite suppressing) and orexigenic (that is appetite stimulating) neuropeptide to control food intake. Loss of melanocortin 4 receptor (MC4R) function, a key MCR expressed in the hypothalamus, is the most common genetic cause of obesity in humans [9].
