**12. PLP supplementation as immunodulatory and anti-inflammatory agent**

Pyridoxal 5′ phosphate (PLP) is an active component of pyridoxine and is a cofactor vital for several inflammatory disorder processes that contribute to immune disorder. In chronic inflammatory diseases, PLP has a reverse relation with plasma TNF-α and IL-6. Throughout inflammation, PLP use enhances its depletion, which means that COVID-19 can be deficient in patients with high inflammatory response. In patients with type-2 diabetes and cardiovascular disorder, groups at greater risk for relatively poor COVID-19 outcomes were reported with low levels

*Novel Treatment Strategy against COVID-19 through Anti-Inflammatory, Antioxidant… DOI: http://dx.doi.org/10.5772/intechopen.100251*

of PLP [40, 41]. Elevated incidence of coagulopathy between many COVID-19 patients was also observed as a result of immune disregulation. In a recent manuscript, PLP intake was associated to ameliorate COVID-19 symptoms by regulate immune functions, lower pro-inflammatory cytokines, preserve endothelial stability and avoid hypercoagulability [42]. Indeed, it was found 30 years ago that platelet accumulation and blood coagulation defects were reduced by PLP amounts [43]. Vitamin B6 (along with B2 and B9) prediculated IL 10, a potent anti-inflammatory and immune suppressant cytokine which can disable monocytes and prevent T cells as well as cells present with the antigen [44]. Patients with COVID-19 often frequently react to the virus by implementing a pro-inflammatory T cell response and secretion. PLP may help dampen the cytokine storm and inflammatory processes suffered by a few patients with COVID-19.
