**3. Future insights**

The use of vitamin B-loaded polymers presents a serious progress in the abovementioned applications and ensures a positive advancement in the upcoming years. Treatments will be more effective and safer owing to the design and functionalization of the various polymeric materials. The potential applications show that the polymeric carriers will progress to a specific active substance to the point where it can be customized to best adapt to a specific component or environment. However, it is important to note that vitamin-loaded polymers have some challenges. First, the number of vitamin-loaded polymers presently accessible for use as the industrial scale is still limited, despite the fact that R&D has advanced from the micro to nano-size scale in the previous decade, exceeding expectations. Secondly, the majority of the tests were improved *in vitro* studies with promising findings, however, the conversion from *in vitro* outcomes to clinical success have been restricted. More clinical trials and data are required to properly understand the mechanism of these polymer carriers. Further, these polymer-carriers must also be biodegradable or have a high capacity to be removed outside the body to minimize accumulation, as well as being non-toxic and non-immunogenic. It is notable to highlight the effect that copolymers or polymer blends might play in adjusting or modifying interactions with the human body in order to control their *in vivo* studies.

In sum, various disadvantages or drawbacks must still be overcome by multiple efforts and focused multidisciplinary scientific collaboration in order to achieve the desired results.
