**9. Riboflavin-UV for inhibition of COVID-19 replication**

Riboflavin with UV light is responsible for irreparable destruction to nucleic acids such as RNA and DNA, which makes it impossible to replicate microbial pathogens. The effectiveness of Riboflavin and UV light against MERS-CoV was demonstrated and it may also be of assistance with SARS-CoV-2 [32]. In fact, riboflavin-UV reduced the SARS-CoV-2 infective titre below the human blood and plasma and platelet identification limit [33]. It may ameliorate the risk of COVID-19 transfusion and reduce other pathogenic organisms in blood products in patients critically ill with COVID-19.
