**Abstract**

Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.

**Keywords:** encapsulatin, vitamin release, vitamin-loaded polymer, B-complex vitamins, nutrients
