**4. Intake and novel applications**

### **4.1 Recommended daily intake of thiamin**

Recommended daily thiamin intake in healthy adult men is 1.2 mg/day, while adult women are 1.1 mg/day. For children aged 1–8 years, recommended intake of vitamin B1 ranges from 0.5 to 0.6 mg/day and for ages 9–13 years, it starts from 0.9 mg/day (**Table 1**) [5]. Thiamin is water-soluble across the placenta. Its requirements increase during pregnancy. Pregnancy also increases the risk of thiamin deficiency when prolonged nausea and vomiting (including hyperemesis gravidarum). The dose of parenteral nutritional supplements is 6 mg/day. The parenteral form can be given by intramuscular (IM) or intravenous (IV) injection. Administration of thiamin intravenously can be given as much as 100 mg over 5 minutes [11].
