**7. Conclusions**

In conclusion, despite the majority of treatments using RL-LED therapy are focused on cosmetic applications, RL-TCLT generates cellular effects that will be used to treat different affections including aging and neurodegenerative disease. For this, is necessary to be prudent to decide the more adequate wavelength, light intensity, and duration of therapy, because according to these parameters will found positive or negative effects. In addition, RL-TCLT seems to improve antioxidant defenses and mitochondrial function by enhancing COX IV activity. In concordance with these findings, we also propose that RL-TCLT stimulates mitochondrial function, both enhancing OXPHOS-mediated mitochondrial bioenergetics and calcium buffering capacity. Finally, we suggest that prolonged exposition to RL-TCLT result in a permanent remodeling of the cell, by a mechanism that involves gene transcription, which results in higher synaptic and cognitive function. Future studies are extremely necessary to solve all the questions regarding the benefits of RL-TCLT.
