**6. Expectations**

The hippocampus, as an important part of the limbic system involved in learning and memory, has been extensively studied for many years. With increased aging in China, the incidence of AD, a progressive degenerative brain disease, is increasing every year. The main clinical symptoms are memory loss and cognitive impairment. Entropic cortex to the hippocampus, hippocampus to the prefrontal cortex, and vDBChATs-dNGIs with the hippocampus as the central link may play important role in spatial memory and declarative memory. Moreover, the damage of any link in the cycle leads to the loss of recent memory. By studying the hippocampal memory circuit and various influencing factors, we hope to improve spatial memory and declarative memory by intervening in every link of the hippocampal memory circuit. At the same time, we can provide new ideas and methods for the treatment of memory impairment-related diseases such as AD, which are helpful to the recovery and improvement of memory function in the damaged hippocampus. Considering the influence of BDNF and other factors on the memory circuit and the effects of various diseases related to memory impairment, we should also extensively study some influencing factors as intervention targets for Huntington's disease, depression, schizophrenia, bipolar disorder, and other diseases. These studies can provide prevention strategies and treatment methods for memory decline caused by force majeure factors such as sex and age. Furthermore, studies on its influencing factors will open other research avenues.
