**6.4 Precipitation method**

When the plant extract is dissolved in an organic solvent of choice, it is dried, which is referred to as precipitation. The surfactant is mixed with water (antisolvent), which also includes surfactant, to create a cohesive combination in order to achieve cohesiveness in the final organic phase of the reaction (aqueous phase). It is feasible to oversaturate the plant extract by adding the prepared organic phase to the aqueous phase in a fast manner (organic solvent to antisolvent). As a consequence, ultrafine particles are produced in large quantities (crystalline or amorphous). This process involves, among other things, the creation of nuclei as well as the growth of

crystals, depending on the temperature. A high nucleation rate combined with a slow crystal development rate is required to do this since a stable solution with a smaller particle size than is presently accessible cannot be achieved without doing so [103].
