**6.2 Precipitation and homogenization methods**

It has been shown that when exposed to high temperatures, precipitated plant extract nano-particles may crystallize and transform into microparticles. Greater energy pressures are thus required to homogenize them in order to avoid the development of microparticles. Because of their crystalline structure, these particles, which may be completely amorphous, completely crystalline, or slightly amorphous in nature, may cause bioavailability and long-term stability problems when used in pesticide formulations. It is necessary to homogenize the precipitated nanosuspension before it can be used to maintain the particle size achieved during precipitation. This method also has the benefit of being able to be used to produce pesticides that have low solubility in both organic and aqueous solutions, which is advantageous in both cases [101].
