**7. Conclusion**

Objective evaluation of biochemical markers is more practical than histological changes, and the formation of pathological damage in tissue occurs after the reflection of pesticide effects on biochemical parameters [92]. However, the results from histological evaluations alone do not necessarily indicate a direct effect of pesticides. In addition to the histopathological evaluation, examining other results and determining the source of the effects in the organism in this way will be accepted as a more accurate scientific approach. In response to the increasing human population on the planet we live in, the ever- increasing use of pesticides in order for agricultural production to meet this, and their presence at certain doses in food and the risk of mixing with the aquatic ecosystem is an important public health problem that will adversely affect the health of living creatures. Even exposure to pesticides in the above- mentioned amounts that are allowed to be taken into the body daily will cause accumulation in the body over a long period of time and, thus the changes primarily reflected in biochemical parameters, and, in the longer term, histopathological changes will occur due to increased tissue destruction. The oxidant/antioxidant balance in the organism may change in favor of oxidants as a result of external factors such as irregularity in physiological reactions or pesticide accumulation that may occur in the body. Thus, the changes occurring in cellular basis primarily provide outputs as a result of biochemical assessments, and when the damage reaches a textural dimension, histopathological results emerge following the changes in tissue integrity. The necessity of use of pesticides is an undeniable fact, considering the objectives it aims, but it is also known that there will be a decrease in pesticide use as a result of obtaining plant breeds, especially by making use of the developments in the field of biotechnology, that are more resistant to foreign factors such as insects, fungi, algae, weeds, bacteria, nematodes and rodents. In addition, more use of the biological control option against the factors that reduce the plant yield at a higher level will also produce beneficial results in terms of human health.

*An Overview of the Biochemical and Histopathological Effects of Insecticides DOI: http://dx.doi.org/10.5772/intechopen.100401*
