**6.1 High pressure homogenization method**

The advantage of this method is the production of pesticides that are poorly soluble in water via the use of high-pressure homogenization. Successful completion of this procedure depends on completing three essential steps: In the first stage, a finely powdered medication is dispersed in a suitable stabilizer solution, resulting in a pre-suspension that is then subjected to further treatment after being stabilized. The pre-suspension is homogenized at a low pressure throughout the following procedure to guarantee consistency. Finally, but certainly not least, it is homogenized at high pressure for about 10 to 25 cycles, or until the desired size is achieved. Despite this, this method is only suitable for the production of highly concentrated nanosuspension formulations rather than diluted nanosuspension formulations since the pesticides must be micronized before they can be delivered to the field [99, 100].
