**5. Factors influence in the development of resistance**

#### **5.1 Frequency of application**

However, usually pesticide or management measures are used, one of the important factors that influence resistance development. With every use, an advantage is given to the resistance insects inside a population. The speed of increase of resistance in any population can usually be faster within the presence of a lower applicable value.

#### **5.2 Dosage and persistence of effect**

The period of pesticide persistence remains effective, additionally referred to as its persistence, relies upon the chemical science of the pesticide, the short of formulation, and also the application rate. The product that gives a persistent impact equally gives continuous selection pressure to multiple species. As an example, an area spray can persist for short time and can choose solely against one generation of mosquitoes [22]. In addition, a residual wall application or a bed

net treatment can persist for months or years providing choice pressure against several generations of an equivalent insect. It is so vital to frequently follow manufacturer and United Nations agency recommendations once victimization such pesticides.
