**1. Introduction**

Decontamination is a fundamental requirement for research facilities where pathogen elimination is critical, and laboratory facility managers routinely employ various methods of fumigation or fogging disinfection in the never-ending battle against contamination. Historically, technologies such as chlorine dioxide and formaldehyde gas systems have been applied in these areas for pathogen disinfection. Likewise, high concentration vaporized hydrogen peroxide has also been relied on to achieve similar outcomes. A large percentage of these methods follow a familiar pattern of solution injection, dwell (contact time), evacuation, and validation; however, not every system delivers the same functionality or efficacy. Differences in formula and design influence personnel hours, material compatibility, and risk management.

While effective, these high concentration solutions come with inherent risks to health and safety. A recent innovation significantly lowers the risk of exposure to high-concentration chemicals— an HHP™ system which combines a 7% hydrogen peroxide solution with a calibrated fogging device to deliver a mixture of gaseous and micro aerosolized particles. Studies performed with this technology demonstrate high level pathogen disinfection across a variety of tested viruses, bacteria, and substrates. This chapter will provide readers with a deeper understanding of essential components and considerations when implementing systems for viral decontamination. This chapter introduces the latest evolution in hydrogen peroxide disinfection of viral pathogens to address these challenges: an HHP system using patented Pulse™ technology.
