**3.1 Intramolecular Stetter reaction**

The first general intra molecular Stetter reaction was reported by Ciganek in 1995. By the next year, Enders et al. explains the first enantioselective intramolecular Stetter reaction. Later, the implementation of chiral NHC's resulted in asymmetric transformation leading to synthesis of enantioselective 1,4-bifunctional compounds. The amino indanol derived chiral triazolium salt and pentafluoroamylsubstituted were developed by Rovis et al. in 2002 for the most efficient catalyst for the enantioselective intramolecular reaction (**Figure 9**) [29–33].
