**Section 4**

**Transcatheter Closure of ASD** 

54 Atrial Septal Defect

Xu, Z., Ludmirsky, A., Eun, LY., Hall, TL., Tran, BC., Fowlkes, JB. & Cain, CA.(2004).

Yamashita, H., Ishii, T., Ishiyama, A., Nakayama, N., Miyoshi, T., Miyamoto, Y., Kitazumi,

ferroelectrics, and frequency control, Vol. 51, Issue 6, pp. 726–736

Science(LNCS), Vol. 5128, pp. 300–310

Controlled ultrasound tissue erosion, IEEE transactions on ultrasonics,

G., Katsuike, Y., Okazaki, M., Azuma, T., Fujisaki, M., Takamoto, S. & Chiba, T.(2008). Computer-aided Delivery of High-Intensity Focused Ultrasound (HIFU) for Creation of an Atrial Septal Defect In vivo, Lecture Notes in Computer

**5** 

*USA* 

**Historical Aspects of Transcatheter** 

**Occlusion of Atrial Septal Defects** 

*University of Texas at Houston Medical School, Houston, TX,* 

Following the description of surgical closure of atrial septal defect (ASD) in early 1950s (Bigelow et al., 1950; Lewis et al., 1953; Gibbon, 1953), it rapidly became a standard therapy of ASDs. Surgical closure of ostium secundum ASDs is safe and effective with negligible mortality (Murphy et al., 1990; Galal et al., 1994; Pastorek et al., 1994), but the morbidity associated with sternotomy/thoracotomy, cardiopulmonary bypass and potential for postoperative complications cannot be avoided. Other disadvantages of surgical therapy are the expense associated with surgical correction, residual surgical scar and psychological trauma to the patients and/or the parents. Presumably because of these reasons, several groups of cardiologists embarked upon developing transcatheter methods of closure of the ASD. The studies of King (King & Mills, 1974; Mills & King, 1976; King et al., 1976), Rashkind (Rashkind, 1975; Rashkind & Cuaso, 1977; Rashkind, 1983) and their associates paved the way for the future development of transcatheter ASD device occlusion methodology. In this chapter, history of development of ASD closure devices will be reviewed. Historical development for occlusion of patent foramen ovale (PFO) will be

Historical aspects of closure of atrial septal defect will be reviewed in this section.

endothelialization of the implanted umbrellas was observed during the follow-up.

King and his associates were successful in occluding the ASD via a transcatheter delivered occluding device and were the first in doing so and reported their studies in mid 70s (King & Mills, 1974; Mills & King, 1976; King et al., 1976). This device is composed of paired, Dacron-covered stainless steel umbrellas (Figure 1A) collapsed into a capsule at the tip of a catheter. A number of sizes of the umbrella were manufactured. King & Mills (1974) initially attempted this technique in experimental animal models. ASDs were created by a punch biopsy technique in adult dogs. Successful device deployment was achieved in five of nine dogs in whom the procedure was attempted. Complete closure of the ASD and

**1. Introduction** 

briefed at the end of the chapter.

**2.1 King and Mill's device** 

**2. Closure of atrial septal defects** 

Srilatha Alapati and P. Syamasundar Rao

## **Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects**

Srilatha Alapati and P. Syamasundar Rao *University of Texas at Houston Medical School, Houston, TX, USA* 

#### **1. Introduction**

Following the description of surgical closure of atrial septal defect (ASD) in early 1950s (Bigelow et al., 1950; Lewis et al., 1953; Gibbon, 1953), it rapidly became a standard therapy of ASDs. Surgical closure of ostium secundum ASDs is safe and effective with negligible mortality (Murphy et al., 1990; Galal et al., 1994; Pastorek et al., 1994), but the morbidity associated with sternotomy/thoracotomy, cardiopulmonary bypass and potential for postoperative complications cannot be avoided. Other disadvantages of surgical therapy are the expense associated with surgical correction, residual surgical scar and psychological trauma to the patients and/or the parents. Presumably because of these reasons, several groups of cardiologists embarked upon developing transcatheter methods of closure of the ASD. The studies of King (King & Mills, 1974; Mills & King, 1976; King et al., 1976), Rashkind (Rashkind, 1975; Rashkind & Cuaso, 1977; Rashkind, 1983) and their associates paved the way for the future development of transcatheter ASD device occlusion methodology. In this chapter, history of development of ASD closure devices will be reviewed. Historical development for occlusion of patent foramen ovale (PFO) will be briefed at the end of the chapter.

#### **2. Closure of atrial septal defects**

Historical aspects of closure of atrial septal defect will be reviewed in this section.

#### **2.1 King and Mill's device**

King and his associates were successful in occluding the ASD via a transcatheter delivered occluding device and were the first in doing so and reported their studies in mid 70s (King & Mills, 1974; Mills & King, 1976; King et al., 1976). This device is composed of paired, Dacron-covered stainless steel umbrellas (Figure 1A) collapsed into a capsule at the tip of a catheter. A number of sizes of the umbrella were manufactured. King & Mills (1974) initially attempted this technique in experimental animal models. ASDs were created by a punch biopsy technique in adult dogs. Successful device deployment was achieved in five of nine dogs in whom the procedure was attempted. Complete closure of the ASD and endothelialization of the implanted umbrellas was observed during the follow-up.

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 59

Rashkind developed a slightly different type of ASD closure device. Rashkind's investigations appear to be parallel to those of King and Mills (Rashkind et al., 1985). The first Rashkind umbrella consisted of three stainless-steel arms covered with medical grade foam (Rashkind & Cuaso, 1977). The central ends of the stainless-steel arms are attached to miniature springs, which in turn are welded to a small central hub. The outer end of the stainless steel arm ended in a miniature "fish" hook. Rashkind subsequently modified this umbrella such that there are six stainless steel arms with the alternate arms carrying the hook (Figure 1B). He also designed an elaborate centering mechanism, which consisted of five arms bent to produce a gentle outward curve. The umbrella delivery mechanism is built on a 6 F catheter with locking tip, which interlocks with the central hub of the device. The entire system is threaded over a guide wire. Withdrawal of the guide wire after implantation of the device will unlock the mechanism, thereby disconnecting the umbrella from the delivery system. The umbrella collapsed into a pod, the centering mechanism folded and the delivery system can all be loaded into a 14 or 16 F long sheath. The umbrellas were manufactured in three sizes: 25, 30 and 35 mm. An umbrella that is approximately twice the stretched size of the ASD is chosen for implantation. First, the tip of the pod containing the umbrella is advanced into the left-atrium through the ASD (Figure 2 a). Then, the umbrella and centering mechanism delivered into the mid left atrium by retracting the tip of the sheath or pod (Figure 2 b). The entire system is then slowly withdrawn. The centering mechanism keeps the umbrella centered over the ASD. Further withdrawal results in embedding the hooks of the umbrella onto the left atrial side of the atrial septum (Figure 2 c). After the umbrella is fixed to the atrial septum, the umbrella delivery system is disconnected and removed. Experimental studies in closing surgically created ASDs in dogs and calves have indicated the feasibility of the method with excellent endothelialization of

**2.2 Rashkind's devices** 

the umbrella components (Rashkind, 1975).

Fig. 2. Sequence of hooked prosthesis implantation (see text for details).

The senior author had the privilege of spending a month-long mini-sabbatical with Dr. William Rashkind in mid-1979 and during that period, had the opportunity in performing ASD device closures with the hooked device, both in calf model and in patients under the

Following this experience in the dog model, the technique was extended to human subjects (Mills & King, 1976; King et al., 1976). Stretched ASD diameter was measured by balloon sizing (King et al., 1978) and a device 10 mm larger than the stretched ASD diameter is selected for deployment. The device delivery catheter is inserted through the saphenous vein at the sapheno-femoral venous junction by cut-down. The catheter tip is positioned into the left atrium through the ASD. The distal umbrella is extruded in the body of the left atrium and the catheter withdrawn into the right atrium. Then, the distal (left atrial) umbrella is fixed against the left side of the atrial septum and the proximal (right atrial) umbrella is opened in the right atrium. The umbrellas are locked to each other with a special locking mechanism. After the device is in place, the obturator wire is unscrewed and withdrawn, thus releasing the device.

Eighteen patients were taken to the catheterization laboratory and ten (56%) of these were considered suitable candidates for device closure. Successful implantation of the device was accomplished in five (50%) patients. Their ages were 17 to 75 years with a median of 24. The stretched ASD diameter was 18 to 26 mm by balloon sizing. Ostium secundum ASD with left-to-right shunt was present in four patients. The fifth patient had an atrial defect with presumed paradoxical embolism and a stroke. Symptoms improved and the heart size decreased during observed follow-up. Repeat cardiac catheterization data did not show shunts by oximetry. However, trivial shunts were observed by hydrogen curves. In a 27 year follow up study, 4 patients remain alive with closed defects and there had been no adverse events related to the device. The deceased patient died from Hodgkin's disease and a cerebral vascular accident 9 years after device closure (King & Mills, 2010).

Although these results were encouraging, King and his associates did not continue their use nor did any other investigator, to our knowledge, pursued the technique. It may be presumed that this may be related to the need for a large delivery sheath and complicated maneuvering required for implantation of the device.

Fig. 1. Photographs of King's device (A), Rashkind's hooked device (B), on-face and side views of the clamshell device (C) and buttoned device (D); see the text for detailed description of the devices.

#### **2.2 Rashkind's devices**

58 Atrial Septal Defect

Following this experience in the dog model, the technique was extended to human subjects (Mills & King, 1976; King et al., 1976). Stretched ASD diameter was measured by balloon sizing (King et al., 1978) and a device 10 mm larger than the stretched ASD diameter is selected for deployment. The device delivery catheter is inserted through the saphenous vein at the sapheno-femoral venous junction by cut-down. The catheter tip is positioned into the left atrium through the ASD. The distal umbrella is extruded in the body of the left atrium and the catheter withdrawn into the right atrium. Then, the distal (left atrial) umbrella is fixed against the left side of the atrial septum and the proximal (right atrial) umbrella is opened in the right atrium. The umbrellas are locked to each other with a special locking mechanism. After the device is in place, the obturator wire is unscrewed and

Eighteen patients were taken to the catheterization laboratory and ten (56%) of these were considered suitable candidates for device closure. Successful implantation of the device was accomplished in five (50%) patients. Their ages were 17 to 75 years with a median of 24. The stretched ASD diameter was 18 to 26 mm by balloon sizing. Ostium secundum ASD with left-to-right shunt was present in four patients. The fifth patient had an atrial defect with presumed paradoxical embolism and a stroke. Symptoms improved and the heart size decreased during observed follow-up. Repeat cardiac catheterization data did not show shunts by oximetry. However, trivial shunts were observed by hydrogen curves. In a 27 year follow up study, 4 patients remain alive with closed defects and there had been no adverse events related to the device. The deceased patient died from Hodgkin's disease and a

Although these results were encouraging, King and his associates did not continue their use nor did any other investigator, to our knowledge, pursued the technique. It may be presumed that this may be related to the need for a large delivery sheath and complicated

Fig. 1. Photographs of King's device (A), Rashkind's hooked device (B), on-face and side views of the clamshell device (C) and buttoned device (D); see the text for detailed

cerebral vascular accident 9 years after device closure (King & Mills, 2010).

maneuvering required for implantation of the device.

description of the devices.

withdrawn, thus releasing the device.

Rashkind developed a slightly different type of ASD closure device. Rashkind's investigations appear to be parallel to those of King and Mills (Rashkind et al., 1985). The first Rashkind umbrella consisted of three stainless-steel arms covered with medical grade foam (Rashkind & Cuaso, 1977). The central ends of the stainless-steel arms are attached to miniature springs, which in turn are welded to a small central hub. The outer end of the stainless steel arm ended in a miniature "fish" hook. Rashkind subsequently modified this umbrella such that there are six stainless steel arms with the alternate arms carrying the hook (Figure 1B). He also designed an elaborate centering mechanism, which consisted of five arms bent to produce a gentle outward curve. The umbrella delivery mechanism is built on a 6 F catheter with locking tip, which interlocks with the central hub of the device. The entire system is threaded over a guide wire. Withdrawal of the guide wire after implantation of the device will unlock the mechanism, thereby disconnecting the umbrella from the delivery system. The umbrella collapsed into a pod, the centering mechanism folded and the delivery system can all be loaded into a 14 or 16 F long sheath. The umbrellas were manufactured in three sizes: 25, 30 and 35 mm. An umbrella that is approximately twice the stretched size of the ASD is chosen for implantation. First, the tip of the pod containing the umbrella is advanced into the left-atrium through the ASD (Figure 2 a). Then, the umbrella and centering mechanism delivered into the mid left atrium by retracting the tip of the sheath or pod (Figure 2 b). The entire system is then slowly withdrawn. The centering mechanism keeps the umbrella centered over the ASD. Further withdrawal results in embedding the hooks of the umbrella onto the left atrial side of the atrial septum (Figure 2 c). After the umbrella is fixed to the atrial septum, the umbrella delivery system is disconnected and removed. Experimental studies in closing surgically created ASDs in dogs and calves have indicated the feasibility of the method with excellent endothelialization of the umbrella components (Rashkind, 1975).

Fig. 2. Sequence of hooked prosthesis implantation (see text for details).

The senior author had the privilege of spending a month-long mini-sabbatical with Dr. William Rashkind in mid-1979 and during that period, had the opportunity in performing ASD device closures with the hooked device, both in calf model and in patients under the

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 61

sheath size required to implant King's and hooked Rashkind's devices. Several device sizes were manufactured: 17 mm, 23 mm, 28 mm and 33 mm. Balloon stretched diameter of the ASD was measured as in the previous device implantation reports and a device at least 1.6 times larger than stretched ASD diameter was recommended for device placement. The delivery catheter is advanced into the left atrium across the ASD, and its tip positioned in mid-left atrium. The distal arms of the device are opened and the device is withdrawn against the atrial septum until the arms are seen to bend. The sheath is pulled back while keeping the device in position with resultant opening of the proximal arms in the right atrium. After ensuring the stability of the device across the atrial septum by fluoroscopic and echocardiographic imaging, the device is released by activating pin-to-pin mechanism. The preliminary clinical experience included 17 clamshell device implantations (Rome et al., 1990). This report (Rome et al., 1990) combines the results of implantation of Rashkind double umbrella, prototype clamshell and clamshell devices and therefore the exact clamshell results are difficult to discern. Forty patients were taken to catheterization laboratory with intent to close, and of these, 34 (85%) had implantation of the device. With the exception of one major complication (death secondary to cerebral embolus, presumably related to dislodgment of iliac vein thrombus during placement of device delivery sheath), the procedures were successful. Embolization of the device into the descending aorta at iliac bifurcation occurred in two (6%) patients. The embolized devices were transcatheter retrieved and the patients sent to elective closure of their ASDs. At short-term follow-up, 12

(63%) of 19 who had adequate echocardiographic study had no residual shunts.

be reviewed later in this chapter.

**2.4 Buttoned device** 

Hellenbrand et al reported use of this device; device implantation was attempted in eleven patients aged 13 months to 46 years (Hellenbrand et al., 1990). The device was implanted successfully in ten patients; the single failure was in their youngest patient weighing 11 kg. The procedures were performed under general anesthesia with endotracheal intubation and transesophageal echo-Doppler (TEE) monitoring; they advocated TEE monitoring during the procedure. Residual shunt was present in one (10%) patient. In the study by Boutin et al (1993), residual shunt was present in 91% immediately following device placement. The residual shunts decreased to 53% at a mean follow-up of 10 months. Actuarial analysis indicated progressive reduction of shunt with time (Boutin et al., 1993). Clinical trials by these and other investigators continued (Boutin et al., 1993; Latson, 1993; Perry et al., 1993). However, fractures of the arms of the device were reported in 40 to 84% of implanted devices with occasional embolization (Justo et al., 1996; Perry et al., 1993; Prieto et al., 1996), which were of concern. Consequently, further clinical trials with the device were suspended in 1991 by the investigators and the FDA. Subsequently the device was modified which will

Sideris et al described "buttoned device" at about the time of transformation of Rashkind double disk device to clamshell device (Sideris et al., 1990 a & b). The device consisted of three components: occluder, counter-occluder and delivery system. The occluder consisted of an x-shaped, Teflon-coated wire skeleton covered with 1/8-in polyurethane foam (Figure 1 D, left component). The wire skeleton of the occluder can be folded, making the wires parallel, which can then be introduced into an 8-French sheath. When delivered to site of implantation, the occluder springs opens into its original square-shaped structure. A 2-mm

direction of Rashkind. Rashkind's enthusiasm and dedication in developing transcatheter closure methodology is laudable and the diligence with which he pursued the project is admirable. Subsequently, Rashkind obtained investigational device exemption from the FDA and began organizing multi-institutional clinical trials in the US in early 1980s. This is probably the first clinical trial for device implantation in pediatric cardiac practice. Unfortunately, Rashkind did not live to witness the conclusion of these trials or to see the monumental effect that his work had on the evolution of transcatheter occlusion technology.

Following experimental studies in animal models, Rashkind studied ASD closure in human subjects (Rashkind, 1983; Rashkind & Cuaso, 1977). A total of 33 patients were recruited for the clinical trial. Device implantation was not attempted in 10 patients because the defect was too large (N=6) to safely implant the device or too small (N=4) to warrant the potential risk of device placement. In the remaining 23 patients, 14 (61%) had adequate ASD closure and in nine (39%) the results were considered unsatisfactory. The initial six device implantations were three-rib umbrellas and the remaining were six-rib prostheses. Urgent surgical intervention was required in some patients to address the unsatisfactory implantations and others underwent elective surgery. However, uneventful surgical closure of the ASD and removal of the device were undertaken in all subjects. Clinical application in a limited number of patients by Beekman et al (1989) showed similar results.

Although good results were achieved in >50% patients, a number of problems were identified: requirement of a large sheath for implantation, uncertainty of whether the tissue will bind to the entire rim of the single disc device and difficulty in disengaging and repositioning the device if the hooks of the umbrella accidentally engage onto the left atrial wall or mitral valve. Because of these reasons, Rashkind modified this device into a double disc prosthesis which he had successfully employed to close an ASD in a cow (Rashkind, 1983). This modification was patterned after a concurrently developed Rashkind's patent ductus arteriosus occluding device (Rashkind, 1983; Rashkind et al., 1987).

#### **2.3 Transformation from Rashkind to clamshell**

The double-umbrella Rashkind device was subsequently utilized in closing ASDs by other workers (Lock et al., 1987, 1989; Rome et al., 1990). Whilst the results appeared good, difficulty in delivering umbrellas on either side of the defect, centering the device because of the angle of the delivery catheter (Lock et al., 1987) and inability of the umbrellas to fold back against each other, the device was modified by introducing a second spring in center of the arms (Lock et al., 1989) and was named Lock Clamshell Occluder. The clamshell device was initially used to occlude experimentally created ASDs in lambs: successful implantation was accomplished in six of the eight lambs. Embolization occurred in the remaining two. Complete occlusion of the ASD was noted in four lambs. Endothelialization of the device components was demonstrated in two lambs followed for 1 and 2 months after device deployment.

The clamshell device is composed of two opposing umbrellas made of 4 steel arms covered with woven Dacron material (Figure 1C). The steel arms are hinged together in the center of the device and the springs in the middle of the arm were introduced to facilitate folding back of the umbrellas against each other, thereby creating a clamshell configuration. The device is delivered through an 11 F sheath, a definitive improvement compared to the

direction of Rashkind. Rashkind's enthusiasm and dedication in developing transcatheter closure methodology is laudable and the diligence with which he pursued the project is admirable. Subsequently, Rashkind obtained investigational device exemption from the FDA and began organizing multi-institutional clinical trials in the US in early 1980s. This is probably the first clinical trial for device implantation in pediatric cardiac practice. Unfortunately, Rashkind did not live to witness the conclusion of these trials or to see the monumental effect that his work had on the evolution of transcatheter occlusion technology. Following experimental studies in animal models, Rashkind studied ASD closure in human subjects (Rashkind, 1983; Rashkind & Cuaso, 1977). A total of 33 patients were recruited for the clinical trial. Device implantation was not attempted in 10 patients because the defect was too large (N=6) to safely implant the device or too small (N=4) to warrant the potential risk of device placement. In the remaining 23 patients, 14 (61%) had adequate ASD closure and in nine (39%) the results were considered unsatisfactory. The initial six device implantations were three-rib umbrellas and the remaining were six-rib prostheses. Urgent surgical intervention was required in some patients to address the unsatisfactory implantations and others underwent elective surgery. However, uneventful surgical closure of the ASD and removal of the device were undertaken in all subjects. Clinical application in

a limited number of patients by Beekman et al (1989) showed similar results.

ductus arteriosus occluding device (Rashkind, 1983; Rashkind et al., 1987).

**2.3 Transformation from Rashkind to clamshell** 

deployment.

Although good results were achieved in >50% patients, a number of problems were identified: requirement of a large sheath for implantation, uncertainty of whether the tissue will bind to the entire rim of the single disc device and difficulty in disengaging and repositioning the device if the hooks of the umbrella accidentally engage onto the left atrial wall or mitral valve. Because of these reasons, Rashkind modified this device into a double disc prosthesis which he had successfully employed to close an ASD in a cow (Rashkind, 1983). This modification was patterned after a concurrently developed Rashkind's patent

The double-umbrella Rashkind device was subsequently utilized in closing ASDs by other workers (Lock et al., 1987, 1989; Rome et al., 1990). Whilst the results appeared good, difficulty in delivering umbrellas on either side of the defect, centering the device because of the angle of the delivery catheter (Lock et al., 1987) and inability of the umbrellas to fold back against each other, the device was modified by introducing a second spring in center of the arms (Lock et al., 1989) and was named Lock Clamshell Occluder. The clamshell device was initially used to occlude experimentally created ASDs in lambs: successful implantation was accomplished in six of the eight lambs. Embolization occurred in the remaining two. Complete occlusion of the ASD was noted in four lambs. Endothelialization of the device components was demonstrated in two lambs followed for 1 and 2 months after device

The clamshell device is composed of two opposing umbrellas made of 4 steel arms covered with woven Dacron material (Figure 1C). The steel arms are hinged together in the center of the device and the springs in the middle of the arm were introduced to facilitate folding back of the umbrellas against each other, thereby creating a clamshell configuration. The device is delivered through an 11 F sheath, a definitive improvement compared to the sheath size required to implant King's and hooked Rashkind's devices. Several device sizes were manufactured: 17 mm, 23 mm, 28 mm and 33 mm. Balloon stretched diameter of the ASD was measured as in the previous device implantation reports and a device at least 1.6 times larger than stretched ASD diameter was recommended for device placement. The delivery catheter is advanced into the left atrium across the ASD, and its tip positioned in mid-left atrium. The distal arms of the device are opened and the device is withdrawn against the atrial septum until the arms are seen to bend. The sheath is pulled back while keeping the device in position with resultant opening of the proximal arms in the right atrium. After ensuring the stability of the device across the atrial septum by fluoroscopic and echocardiographic imaging, the device is released by activating pin-to-pin mechanism.

The preliminary clinical experience included 17 clamshell device implantations (Rome et al., 1990). This report (Rome et al., 1990) combines the results of implantation of Rashkind double umbrella, prototype clamshell and clamshell devices and therefore the exact clamshell results are difficult to discern. Forty patients were taken to catheterization laboratory with intent to close, and of these, 34 (85%) had implantation of the device. With the exception of one major complication (death secondary to cerebral embolus, presumably related to dislodgment of iliac vein thrombus during placement of device delivery sheath), the procedures were successful. Embolization of the device into the descending aorta at iliac bifurcation occurred in two (6%) patients. The embolized devices were transcatheter retrieved and the patients sent to elective closure of their ASDs. At short-term follow-up, 12 (63%) of 19 who had adequate echocardiographic study had no residual shunts.

Hellenbrand et al reported use of this device; device implantation was attempted in eleven patients aged 13 months to 46 years (Hellenbrand et al., 1990). The device was implanted successfully in ten patients; the single failure was in their youngest patient weighing 11 kg. The procedures were performed under general anesthesia with endotracheal intubation and transesophageal echo-Doppler (TEE) monitoring; they advocated TEE monitoring during the procedure. Residual shunt was present in one (10%) patient. In the study by Boutin et al (1993), residual shunt was present in 91% immediately following device placement. The residual shunts decreased to 53% at a mean follow-up of 10 months. Actuarial analysis indicated progressive reduction of shunt with time (Boutin et al., 1993). Clinical trials by these and other investigators continued (Boutin et al., 1993; Latson, 1993; Perry et al., 1993). However, fractures of the arms of the device were reported in 40 to 84% of implanted devices with occasional embolization (Justo et al., 1996; Perry et al., 1993; Prieto et al., 1996), which were of concern. Consequently, further clinical trials with the device were suspended in 1991 by the investigators and the FDA. Subsequently the device was modified which will be reviewed later in this chapter.

#### **2.4 Buttoned device**

Sideris et al described "buttoned device" at about the time of transformation of Rashkind double disk device to clamshell device (Sideris et al., 1990 a & b). The device consisted of three components: occluder, counter-occluder and delivery system. The occluder consisted of an x-shaped, Teflon-coated wire skeleton covered with 1/8-in polyurethane foam (Figure 1 D, left component). The wire skeleton of the occluder can be folded, making the wires parallel, which can then be introduced into an 8-French sheath. When delivered to site of implantation, the occluder springs opens into its original square-shaped structure. A 2-mm

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 63

Fig. 3. Second, third and fourth generation buttoned devices; see the text for details. Occ,

Fig. 4. Selected cinefluorograms in AP view demonstration the buttoning: the occluder (O) and the counter-occluder (CO) are past the radio-opaque button (B). LW, loading wire.

During the initial period of the clinical trials the device delivery required cutting the valve component of the delivery sheath which was then re-attached after loading the device into the sheath (Sideris et al., 1990b; Rao et al., 1991; Rao et al., 1992 a & b). This step was subsequently eliminated by directly loading the device into a short sheath which was then introduced thru' the valve of the delivery sheath (Rao, 2003). During this period the device was directly delivered across the defect. In cases with misplacement or slippage of the occluder into the right atrium, it was difficult to reposition the occluder and it had to be retrieved out of the patient, damaging the device. Therefore, over-the-wire delivery technique was developed. The implantation of the device is similar to direct delivery except the central foam part (close to middle of the X) is pierced with the end of 025" Amplatz wire and the wire is removed at the end of the procedure. The majority of devices were delivered

occluder; ROB, Radio-opaque button, NT, nylon thread; LW, loading wire.

string loop made of silk thread is attached to the center of the occluder; the loop is closed with a 1-mm knot (button). The counter-occluder is composed of a single strand, Tefloncoated wire skeleton covered with rhomboid shaped polyurethane foam (Figure 1 D, right component). A rubber piece is sutured in its center and becomes a buttonhole. The delivery system consisted of a) Teflon-coated 0.035-in guide wire (loading wire), b) a folded 0.008-in nylon thread passing through the guide wire, after having its core removed. The loop of this thread passes through the loop in the center of the occluder, c) an 8-French or 9-French long sheath for device delivery and implantation and d) an 8-French pusher catheter to advance the occluder and counter occluder within the sheath. This may be considered first generation buttoned device. The device was manufactured in 5-mm increments beginning with 25-mm size. The device size was measured by the diagonal length of the occluder and is same as the length of the counter-occluder.

Atrial septal defects were produced in piglets. The buttoned device was successfully implanted in 17 (85%) of 20 attempts. The failures were in the first three animals; presumably related inexperience of the operator and design imperfections (Sideris et al., 1990a). Full occlusion of the ASD and endothelialization of the device was demonstrated in all the 17 successful implantations.

During the preliminary clinical experience with this device (Rao et al., 1992a), minutes after implantation of the device, it spontaneously dislodged from the ASD site in one child. Inspection of the surgically explanted device revealed that the tie binding the occluder with the counter-occluder was torn. It seemed that excessive force was used while buttoning the components of the device across the atrial septum, to ensure adequate buttoning. Based on this undesirable experience, the device was modified by a) strengthening the button-loop by replacing the silk tie with 4-lb proof nylon, b) introducing a radio-opaque marker on the button, so that passage of the buttonhole of the counter-occluder over the button can be visualized by fluoroscopy. Consequently, there will be no need to use excessive force and c) the 1/8-in polyurethane foam covering the wire skeleton was replaced with thinner 1/16-in foam. This is considered second-generation of the buttoned device (Figure 3, left).

While incorporation of radio-opacity in the button made easy visualization of the button (Figure 4), it produced eccentricity of the button (Figure 3, left). This created additional difficulty in buttoning. Therefore, an additional loop of nylon thread was added immediately below the button (Figure 3, middle). This transformed the eccentric button of the second-generation device to be aligned straight, thus making it easier to button the occluder and counter-occluder across the atrial septum; this became third-generation device. Although the prevalence of unbuttoning decreased with the introduction of the additional loop (Rao et al,. 1994), buttoning across a thick atrial septum, especially when closing patent foramen ovale for prevention of presumed paradoxical embolism (Ende et al., 1996), became difficult with the radio-opaque wire of the counter-occluder swayed away from radioopaque button despite "adequate buttoning." This, along with our experience with buttoned device for patent ductus arteriosus (Rao et al., 1993) in which we used two knots (buttons), the device was further modified such that an 8-mm string loop is attached to the occluder with two knots (buttons) on it, 4-mm and 8-mm from the occluder (Figure 3, right). Radioopaque spring buttons were incorporated into both the knots. A sketch with details of the button loop and photographs of the fourth generation device are shown in figures 5 and 6, respectively.

string loop made of silk thread is attached to the center of the occluder; the loop is closed with a 1-mm knot (button). The counter-occluder is composed of a single strand, Tefloncoated wire skeleton covered with rhomboid shaped polyurethane foam (Figure 1 D, right component). A rubber piece is sutured in its center and becomes a buttonhole. The delivery system consisted of a) Teflon-coated 0.035-in guide wire (loading wire), b) a folded 0.008-in nylon thread passing through the guide wire, after having its core removed. The loop of this thread passes through the loop in the center of the occluder, c) an 8-French or 9-French long sheath for device delivery and implantation and d) an 8-French pusher catheter to advance the occluder and counter occluder within the sheath. This may be considered first generation buttoned device. The device was manufactured in 5-mm increments beginning with 25-mm size. The device size was measured by the diagonal length of the occluder and

Atrial septal defects were produced in piglets. The buttoned device was successfully implanted in 17 (85%) of 20 attempts. The failures were in the first three animals; presumably related inexperience of the operator and design imperfections (Sideris et al., 1990a). Full occlusion of the ASD and endothelialization of the device was demonstrated in

During the preliminary clinical experience with this device (Rao et al., 1992a), minutes after implantation of the device, it spontaneously dislodged from the ASD site in one child. Inspection of the surgically explanted device revealed that the tie binding the occluder with the counter-occluder was torn. It seemed that excessive force was used while buttoning the components of the device across the atrial septum, to ensure adequate buttoning. Based on this undesirable experience, the device was modified by a) strengthening the button-loop by replacing the silk tie with 4-lb proof nylon, b) introducing a radio-opaque marker on the button, so that passage of the buttonhole of the counter-occluder over the button can be visualized by fluoroscopy. Consequently, there will be no need to use excessive force and c) the 1/8-in polyurethane foam covering the wire skeleton was replaced with thinner 1/16-in

foam. This is considered second-generation of the buttoned device (Figure 3, left).

While incorporation of radio-opacity in the button made easy visualization of the button (Figure 4), it produced eccentricity of the button (Figure 3, left). This created additional difficulty in buttoning. Therefore, an additional loop of nylon thread was added immediately below the button (Figure 3, middle). This transformed the eccentric button of the second-generation device to be aligned straight, thus making it easier to button the occluder and counter-occluder across the atrial septum; this became third-generation device. Although the prevalence of unbuttoning decreased with the introduction of the additional loop (Rao et al,. 1994), buttoning across a thick atrial septum, especially when closing patent foramen ovale for prevention of presumed paradoxical embolism (Ende et al., 1996), became difficult with the radio-opaque wire of the counter-occluder swayed away from radioopaque button despite "adequate buttoning." This, along with our experience with buttoned device for patent ductus arteriosus (Rao et al., 1993) in which we used two knots (buttons), the device was further modified such that an 8-mm string loop is attached to the occluder with two knots (buttons) on it, 4-mm and 8-mm from the occluder (Figure 3, right). Radioopaque spring buttons were incorporated into both the knots. A sketch with details of the button loop and photographs of the fourth generation device are shown in figures 5 and 6,

is same as the length of the counter-occluder.

all the 17 successful implantations.

respectively.

Fig. 3. Second, third and fourth generation buttoned devices; see the text for details. Occ, occluder; ROB, Radio-opaque button, NT, nylon thread; LW, loading wire.

Fig. 4. Selected cinefluorograms in AP view demonstration the buttoning: the occluder (O) and the counter-occluder (CO) are past the radio-opaque button (B). LW, loading wire.

During the initial period of the clinical trials the device delivery required cutting the valve component of the delivery sheath which was then re-attached after loading the device into the sheath (Sideris et al., 1990b; Rao et al., 1991; Rao et al., 1992 a & b). This step was subsequently eliminated by directly loading the device into a short sheath which was then introduced thru' the valve of the delivery sheath (Rao, 2003). During this period the device was directly delivered across the defect. In cases with misplacement or slippage of the occluder into the right atrium, it was difficult to reposition the occluder and it had to be retrieved out of the patient, damaging the device. Therefore, over-the-wire delivery technique was developed. The implantation of the device is similar to direct delivery except the central foam part (close to middle of the X) is pierced with the end of 025" Amplatz wire and the wire is removed at the end of the procedure. The majority of devices were delivered

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 65

Fig. 7. Photographs of centering buttoned device with the centering mechanism open

Fig. 8. Photograph of inverted buttoned device. COc, counter occluder; OCC, Occluder.

Fig. 9. Photographs of centering on demand buttoned device with the centering mechanism

(left panel) and closed (right panel).

open (left panel) and closed (right panel).

by the over-the-wire technique in the later part of fourth generation device trials (Rao & Sideris, 1998; Rao et al., 2000; Rao, 2003).

Fig. 5. Cartoon of the fourth generation buttoned device (right) with details of the buttoned loop (BL) (left). The buttoned loop (BL) includes two "spring" buttons positioned 4-mm apart. During buttoning, the spring button becomes straightened in line with the button loop. After buttoning the radio-opaque spring button becomes perpendicular, preventing unbuttoning. COcc, counter-occluder; DW, delivery wire; NT, nylon thread; Occ, occluder; Sh, sheath.

Fig. 6. Photographs of fourth generation buttoned device in multiple views.

Concomitantly a number of other modifications of the device were introduced which include, centering device (Sideris et al., 1996) to center the device over the defect (Figure 7), inverted device (Rao et al. 1997;) to address closure of right to left shunts (Figure 8), centering on demand device (Sideris et al., 1997; Rao & Sideris 2001) to center the device when necessary (Figure 9) and hybrid device (Rao, 2003) to address closure of defects with associated with atrial septal aneurysm (Figure 10).

by the over-the-wire technique in the later part of fourth generation device trials (Rao &

Fig. 5. Cartoon of the fourth generation buttoned device (right) with details of the buttoned loop (BL) (left). The buttoned loop (BL) includes two "spring" buttons positioned 4-mm apart. During buttoning, the spring button becomes straightened in line with the button loop. After buttoning the radio-opaque spring button becomes perpendicular, preventing unbuttoning. COcc, counter-occluder; DW, delivery wire; NT, nylon thread; Occ, occluder;

Fig. 6. Photographs of fourth generation buttoned device in multiple views.

associated with atrial septal aneurysm (Figure 10).

Concomitantly a number of other modifications of the device were introduced which include, centering device (Sideris et al., 1996) to center the device over the defect (Figure 7), inverted device (Rao et al. 1997;) to address closure of right to left shunts (Figure 8), centering on demand device (Sideris et al., 1997; Rao & Sideris 2001) to center the device when necessary (Figure 9) and hybrid device (Rao, 2003) to address closure of defects with

Sideris, 1998; Rao et al., 2000; Rao, 2003).

Sh, sheath.

Fig. 7. Photographs of centering buttoned device with the centering mechanism open (left panel) and closed (right panel).

Fig. 8. Photograph of inverted buttoned device. COc, counter occluder; OCC, Occluder.

Fig. 9. Photographs of centering on demand buttoned device with the centering mechanism open (left panel) and closed (right panel).

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 67

occluder disc, which was treated with tissue plasminogen activator (tPA). The clot resolved without complications. At the time of that report (Rao and Sideris, 2001), short-term followup indicated that no further interventions had been required. An updated experience in 80

The device has also been successfully used to close atrial defects presumed to be responsible for paradoxical embolism and cerebrovascular accidents (Ende et al., 1996), patent foramen ovale causing hypoxemia in platypnea-orthodeoxia syndrome in the elderly (Rao et al., 2001) and persistent right to left shunt associated with previously operated complex

A number of single institutional (Sideris et al., 1990; Rao et al., 1991; Rao et al., 1992a; Rao et al., 1992b; Rao et al., 1995; Arora et al., 1996; Haddad et al., 1996; Worms et al., 1996) and multi-institutional (Rao et al., 1994; Lloyd et al., 1994; Zamora et al., 1998; Rao et al., 1998; Rao & Sideris et al., 1998; Rao et al., 2000; Rao and Sideris, 2001) clinical trials were undertaken which demonstrated feasibility, safety and effectiveness of this device. However, pre-market-approval (PMA) application was not made and consequently the

Pavcnik et al (Pavcnik et al., 1993) designed a monodisk device. The device consists of a stainless steel ring constructed with wire coil covered with two layers of nylon mesh. Three hollow pieces of braided stainless steel wires were sutured onto the right atrial side of the device (Figure 11). Three strands of monofilament nylon pass through, one in each of the hollow wires. The nylon thread also passes through the delivery catheter. The entire system

Fig. 11. Photographs of the monodisk device showing tilted side profile of the device after having opened it following passage through a model atrial septal defect (left top). Right atrial views of the device after having the device pulled against the model atrial septal defect prior to (right upper) and after (right lower) releasing flexible wires against the atrial septum are shown. Final position of the device (left lower) after disconnecting device by

congenital cardiac anomalies, including Fontan fenestrations (Rao et al., 1997).

device is not approved by the FDA and is not available for general clinical use.

patients (Rao, 2003) indicated similar results.

**2.5 Monodisk device** 

cutting monofilament nylon.

Fig. 10. Photograph of a hybrid device with square-shaped counter occluder on the aright atrial side, particular usefully with ASDs with atrial septal aneurysms.

A comprehensive review and comparison from international and US trials of the first four generations of buttoned device and the COD device was presented in 2001 (Rao and Sideris, 2001). The first three generation devices were used during a 3.5-year period ending in February 1993 in 180 patients at 16 institutions around the world (Rao et al., 1994). The ASD size varied between 5 and 25 mm. The device size varied between 25 and 50 mm. Successful implantation rate was 92% (166/180). Effective closure, defined as no (92 patients) or trivial (62 patients) shunt by echocardiography within 24 hours was achieved in 154 patients (92%). Unbuttoning occurred in 13 patients (7.2%) and of these, 10 (5.5%) had surgical retrieval and closure of their ASD. In a 7 -year follow-up study (Rao at al. 2000), residual shunts were closed surgically in 13 and by catheter methodology in 1 patient. In the remaining patients, the shunt either disappeared or decreased. The fourth generation device was implanted during a 4-year period ending in September 1997 in 423 patients at 40 institutions worldwide (Rao et al., 2000). The ASD size varied between 5 and 30 mm (median 17 mm). The device size varied between 25 and 60 mm and the successful implantation rate was 99.8% (422/423). Unbuttoning diminished to 0.9% and device embolization occurred in only one patient. Four patients had device retrieval and subsequent surgical repair and one patient required urgent surgical retrieval and ASD repair. Effective closure, as previously defined, was 90% (377 /417). Follow-up data were available up to a 5-year period in 333 of 417 patients (80%). During this period re-intervention occurred in 21 patients (5%) mainly due to residual shunts. This included 11 patients requiring surgical closure and 9 patients receiving a second device. In the remaining patients, there was a gradual reduction in residual shunt. The COD device was implanted in 65 of 68 patients (95.6%) during an 18 month period ending in July 2000 (Rao and Sideris, 2001). In the remaining 3 patients, the device was not implanted either because of a large defect with deficient rims (n = 1) or because the device was unstable (n = 2). In the latter two patients, the device was transcatheter retrieved, and all three patients underwent successful surgical closure electively. Based on echo-Doppler studies performed within 24 hours of device implantation, effective occlusion defined as no (n = 45; 69%) or trivial (n = 17; 26%) shunt was seen in 62 (95.4%) of 65 patients. In the remaining three, residual shunts were small and were followed-up clinically. One pediatric patient had a suspected thrombus on the occluder disc, which was treated with tissue plasminogen activator (tPA). The clot resolved without complications. At the time of that report (Rao and Sideris, 2001), short-term followup indicated that no further interventions had been required. An updated experience in 80 patients (Rao, 2003) indicated similar results.

The device has also been successfully used to close atrial defects presumed to be responsible for paradoxical embolism and cerebrovascular accidents (Ende et al., 1996), patent foramen ovale causing hypoxemia in platypnea-orthodeoxia syndrome in the elderly (Rao et al., 2001) and persistent right to left shunt associated with previously operated complex congenital cardiac anomalies, including Fontan fenestrations (Rao et al., 1997).

A number of single institutional (Sideris et al., 1990; Rao et al., 1991; Rao et al., 1992a; Rao et al., 1992b; Rao et al., 1995; Arora et al., 1996; Haddad et al., 1996; Worms et al., 1996) and multi-institutional (Rao et al., 1994; Lloyd et al., 1994; Zamora et al., 1998; Rao et al., 1998; Rao & Sideris et al., 1998; Rao et al., 2000; Rao and Sideris, 2001) clinical trials were undertaken which demonstrated feasibility, safety and effectiveness of this device. However, pre-market-approval (PMA) application was not made and consequently the device is not approved by the FDA and is not available for general clinical use.

#### **2.5 Monodisk device**

66 Atrial Septal Defect

Fig. 10. Photograph of a hybrid device with square-shaped counter occluder on the aright

A comprehensive review and comparison from international and US trials of the first four generations of buttoned device and the COD device was presented in 2001 (Rao and Sideris, 2001). The first three generation devices were used during a 3.5-year period ending in February 1993 in 180 patients at 16 institutions around the world (Rao et al., 1994). The ASD size varied between 5 and 25 mm. The device size varied between 25 and 50 mm. Successful implantation rate was 92% (166/180). Effective closure, defined as no (92 patients) or trivial (62 patients) shunt by echocardiography within 24 hours was achieved in 154 patients (92%). Unbuttoning occurred in 13 patients (7.2%) and of these, 10 (5.5%) had surgical retrieval and closure of their ASD. In a 7 -year follow-up study (Rao at al. 2000), residual shunts were closed surgically in 13 and by catheter methodology in 1 patient. In the remaining patients, the shunt either disappeared or decreased. The fourth generation device was implanted during a 4-year period ending in September 1997 in 423 patients at 40 institutions worldwide (Rao et al., 2000). The ASD size varied between 5 and 30 mm (median 17 mm). The device size varied between 25 and 60 mm and the successful implantation rate was 99.8% (422/423). Unbuttoning diminished to 0.9% and device embolization occurred in only one patient. Four patients had device retrieval and subsequent surgical repair and one patient required urgent surgical retrieval and ASD repair. Effective closure, as previously defined, was 90% (377 /417). Follow-up data were available up to a 5-year period in 333 of 417 patients (80%). During this period re-intervention occurred in 21 patients (5%) mainly due to residual shunts. This included 11 patients requiring surgical closure and 9 patients receiving a second device. In the remaining patients, there was a gradual reduction in residual shunt. The COD device was implanted in 65 of 68 patients (95.6%) during an 18 month period ending in July 2000 (Rao and Sideris, 2001). In the remaining 3 patients, the device was not implanted either because of a large defect with deficient rims (n = 1) or because the device was unstable (n = 2). In the latter two patients, the device was transcatheter retrieved, and all three patients underwent successful surgical closure electively. Based on echo-Doppler studies performed within 24 hours of device implantation, effective occlusion defined as no (n = 45; 69%) or trivial (n = 17; 26%) shunt was seen in 62 (95.4%) of 65 patients. In the remaining three, residual shunts were small and were followed-up clinically. One pediatric patient had a suspected thrombus on the

atrial side, particular usefully with ASDs with atrial septal aneurysms.

Pavcnik et al (Pavcnik et al., 1993) designed a monodisk device. The device consists of a stainless steel ring constructed with wire coil covered with two layers of nylon mesh. Three hollow pieces of braided stainless steel wires were sutured onto the right atrial side of the device (Figure 11). Three strands of monofilament nylon pass through, one in each of the hollow wires. The nylon thread also passes through the delivery catheter. The entire system

Fig. 11. Photographs of the monodisk device showing tilted side profile of the device after having opened it following passage through a model atrial septal defect (left top). Right atrial views of the device after having the device pulled against the model atrial septal defect prior to (right upper) and after (right lower) releasing flexible wires against the atrial septum are shown. Final position of the device (left lower) after disconnecting device by cutting monofilament nylon.

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 69

Fig. 12. Photographs of ASDOS (A), Das Angel Wing (B), CardioSEAL (C) and STARFlex (D)

Initial clinical trials in adult subjects (Babic et al., 1991; Sievert et al., 1995) and children (Hausdorf et al., 1996) demonstrated feasibility of the method and a multi-institutional clinical trial in 20 European institutions began (Sievert et al., 1998). Babic (Babic, 2000; Babic et al., 2003) reviewed the experience with the ASDOS system, including the European multiinstitutional study. Between 1995 and 1998, closure was attempted in 350 patients (ASDOS registry, December 1998); 261 had ASDs and 89 had PFOs. It should be noted that 800 patients with ASD were screened and 261 (33%) of these were selected for device closure. Three hundred and eighteen patients (91%) had successful implantation. There were 32 (9%) failures; 26 devices were retrieved via catheter (7%) and 6 devices retrieved by surgery (2%). Early embolization was noted in 3 (0.9%), thromboemboli in 3 (0.9%), perforations in 6 (1.6%) and suspected infections in 2 (0.6%). Embolizations were to the right ventricular outflow tract, the abdominal aorta and the pulmonary artery. There were no late dislodgments or embolizations. Residual shunts were noted in 25% to 30% of patients and in some patients the shunt closed over time. A medium-to-large shunt remained in 8% and the defects were surgically repaired because of no shunt reduction with time. During follow-up, surgical extraction was performed in 11 (3%) patients. The complications include frame fractures in 20% of patients, thrombus formation in 25% patients and atrial wall perforation in 1.5% patients. Presumably because of these complications, the device was renounced by the inventor (Babic et al., 2003) and is not currently used. A modified version with a stent between the umbrellas to provide optimal centering along with other changes was

In 1993, Das and his colleagues (Das et al., 1993) designed a self-centering device, delivered transvenously via an 11 F sheath and named it Das Angel Wing Device (Figure 12B). This device had two polyester fabric-covered square frames and a Nitinol frame with midpoint torsion spring eyelets. A circular hole with a diameter equal to one-half of the size of the disk was punched from the right disk with the margins sewn to the left-sided disk forming a

devices; see the text for detailed description of the devices.

conceived, but not available for clinical use (Babic et al. 2003).

**2.8 Das Angel Wing Device** 

can be loaded and the device delivered through a 9 F sheath. Once the device is opened in the left atrium, it is withdrawn against the atrial septum so that the hollow wires are positioned onto the right atrial side of the septum (Figure 11, right upper panel). The nylon filaments are cut, which allow the wires to spring back and detach the device from the delivery catheter (Figure 11, right lower and left lower).

Device implantation to occlude five experimentally created ASDs in dogs was undertaken. The position of the device was good in all dogs and there was no residual shunt. In four dogs, postmortem studies were performed six months later, which showed the device to be in place with incorporation into the atrial septum and excellent endothelialization. The device was used successfully in two patients with secundum ASD (personal communication: D. Pavčnik, December 2000). More recently, a biodisk device was developed and animal experimentation suggested that device deployment is feasible, safe and effective (Pavčnik et al., 2010). The authors recommended long-term studies were to evaluate its long-term effectiveness.

#### **2.6 Modified Rashkind PDA umbrella device**

The Rashkind PDA umbrella (Rashkind et al., 1987) device was modified by bending the arms of the device such that there is a better apposition of the umbrellas against each other and the atrial septum (Redington & Rigby, 1994). The device was used to occlude four ASDs with left-to-right shunt. In two (50%) patients, the ASD was successfully closed. The remaining two (50%) patients required surgical removal of the device along with closure of the ASD. The device was also used to occlude 11 fenestrated Fontans. In nine patients, there was improvement in oxygen saturation. In the remaining two (18%), the procedure failed. To my knowledge, there are no other reports on the use of this modification by this or other workers. In addition, a similar bend placed in the clamshell device has resulted in breakage of the arms, forcing its removal from use. Therefore, advisability of introducing such a bend in the Rashkind PDA device was questioned (Rao & Sideris, 1995).

#### **2.7 Atrial Septal Defect Occluding System (ASDOS)**

Babic and his associates (Babic et al., 1991) described a double umbrella device implanted via arterio-venous guide wire loop in 1991. They named it ASDOS (atrial septal defect occluding system) (Sievert et al., 1995; 1998). In the initial prototype, once the device was locked in place, it required surgical removal for suboptimal positioning. The device underwent further modifications and the updated prototype was released in 1994. This version consists of two major components: (1) a prosthesis consisting of two self-opening umbrellas made of Nitinol wire frame and a thin membrane of polyurethane (Figure 12A) and (2) a delivery system. Each umbrella has five arms, which assume a round shape in the open position. When joined together, the umbrellas assume a discoid shape in profile and a "flower" shape in the frontal view. Umbrella sizes from 25 mm to 50 mm; with 5mm increments were manufactured. This system uses 11-F long sheath for device deployment.

Inter-atrial communications were created with dilatation balloons in 20 pigs and their defects closed with ASDOS device. Examination 3, 4 and 6 months after device closure revealed that devices were completely covered with smooth, scar-like tissue after three months of the procedure (Schneider et al., 1995; Thomsen-Bloch, 1995).

can be loaded and the device delivered through a 9 F sheath. Once the device is opened in the left atrium, it is withdrawn against the atrial septum so that the hollow wires are positioned onto the right atrial side of the septum (Figure 11, right upper panel). The nylon filaments are cut, which allow the wires to spring back and detach the device from the

Device implantation to occlude five experimentally created ASDs in dogs was undertaken. The position of the device was good in all dogs and there was no residual shunt. In four dogs, postmortem studies were performed six months later, which showed the device to be in place with incorporation into the atrial septum and excellent endothelialization. The device was used successfully in two patients with secundum ASD (personal communication: D. Pavčnik, December 2000). More recently, a biodisk device was developed and animal experimentation suggested that device deployment is feasible, safe and effective (Pavčnik et al., 2010). The authors recommended long-term studies were to

The Rashkind PDA umbrella (Rashkind et al., 1987) device was modified by bending the arms of the device such that there is a better apposition of the umbrellas against each other and the atrial septum (Redington & Rigby, 1994). The device was used to occlude four ASDs with left-to-right shunt. In two (50%) patients, the ASD was successfully closed. The remaining two (50%) patients required surgical removal of the device along with closure of the ASD. The device was also used to occlude 11 fenestrated Fontans. In nine patients, there was improvement in oxygen saturation. In the remaining two (18%), the procedure failed. To my knowledge, there are no other reports on the use of this modification by this or other workers. In addition, a similar bend placed in the clamshell device has resulted in breakage of the arms, forcing its removal from use. Therefore, advisability of introducing such a bend

Babic and his associates (Babic et al., 1991) described a double umbrella device implanted via arterio-venous guide wire loop in 1991. They named it ASDOS (atrial septal defect occluding system) (Sievert et al., 1995; 1998). In the initial prototype, once the device was locked in place, it required surgical removal for suboptimal positioning. The device underwent further modifications and the updated prototype was released in 1994. This version consists of two major components: (1) a prosthesis consisting of two self-opening umbrellas made of Nitinol wire frame and a thin membrane of polyurethane (Figure 12A) and (2) a delivery system. Each umbrella has five arms, which assume a round shape in the open position. When joined together, the umbrellas assume a discoid shape in profile and a "flower" shape in the frontal view. Umbrella sizes from 25 mm to 50 mm; with 5mm increments were manufactured. This system uses 11-F long sheath for device deployment. Inter-atrial communications were created with dilatation balloons in 20 pigs and their defects closed with ASDOS device. Examination 3, 4 and 6 months after device closure revealed that devices were completely covered with smooth, scar-like tissue after three

delivery catheter (Figure 11, right lower and left lower).

evaluate its long-term effectiveness.

**2.6 Modified Rashkind PDA umbrella device** 

in the Rashkind PDA device was questioned (Rao & Sideris, 1995).

months of the procedure (Schneider et al., 1995; Thomsen-Bloch, 1995).

**2.7 Atrial Septal Defect Occluding System (ASDOS)** 

Fig. 12. Photographs of ASDOS (A), Das Angel Wing (B), CardioSEAL (C) and STARFlex (D) devices; see the text for detailed description of the devices.

Initial clinical trials in adult subjects (Babic et al., 1991; Sievert et al., 1995) and children (Hausdorf et al., 1996) demonstrated feasibility of the method and a multi-institutional clinical trial in 20 European institutions began (Sievert et al., 1998). Babic (Babic, 2000; Babic et al., 2003) reviewed the experience with the ASDOS system, including the European multiinstitutional study. Between 1995 and 1998, closure was attempted in 350 patients (ASDOS registry, December 1998); 261 had ASDs and 89 had PFOs. It should be noted that 800 patients with ASD were screened and 261 (33%) of these were selected for device closure. Three hundred and eighteen patients (91%) had successful implantation. There were 32 (9%) failures; 26 devices were retrieved via catheter (7%) and 6 devices retrieved by surgery (2%). Early embolization was noted in 3 (0.9%), thromboemboli in 3 (0.9%), perforations in 6 (1.6%) and suspected infections in 2 (0.6%). Embolizations were to the right ventricular outflow tract, the abdominal aorta and the pulmonary artery. There were no late dislodgments or embolizations. Residual shunts were noted in 25% to 30% of patients and in some patients the shunt closed over time. A medium-to-large shunt remained in 8% and the defects were surgically repaired because of no shunt reduction with time. During follow-up, surgical extraction was performed in 11 (3%) patients. The complications include frame fractures in 20% of patients, thrombus formation in 25% patients and atrial wall perforation in 1.5% patients. Presumably because of these complications, the device was renounced by the inventor (Babic et al., 2003) and is not currently used. A modified version with a stent between the umbrellas to provide optimal centering along with other changes was conceived, but not available for clinical use (Babic et al. 2003).

#### **2.8 Das Angel Wing Device**

In 1993, Das and his colleagues (Das et al., 1993) designed a self-centering device, delivered transvenously via an 11 F sheath and named it Das Angel Wing Device (Figure 12B). This device had two polyester fabric-covered square frames and a Nitinol frame with midpoint torsion spring eyelets. A circular hole with a diameter equal to one-half of the size of the disk was punched from the right disk with the margins sewn to the left-sided disk forming a

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 71

41% immediately following the procedure, which decreased to 31% at time of discharge and to 21% six and 12 months later. During follow-up surgery was required in two more patients and wire frame fractures were observed in 6.1% patients. The authors concludes that these devices are useful to close small to moderate ASDs and when used to close large defects, complications or less than optimal results are likely. Similar results were reported in the Canadian experience

STARFlex was further modified by replacing Dacron with bio-absorbable materials: BioSTAR and BioTREK; these devices will be discussed in a latter section of this paper.

In 1997, a new self-expanding Nitinol prosthesis was developed by Dr. Kurt Amplatz, which consists of two self-expandable round disks connected to each other with a short connecting waist (Sharafuddin et al., 1997) and is commonly referred to as Amplatzer septal occluder (Figure 13 A). Nitinol is a nickel-titanium compound consisting of 55% nickel and 45% titanium and has a property of resuming the original shape (shape memory) when deployed. The device size is determined by the waist diameter and ranges from 4 to 40 mm.

Fig. 13. Photographs of Amplatzer septal occluder (A), PFO Occluder (B), fenestrated

ASDs were created surgically in 15 mini-pigs; the ASD diameter ranged between 10 and 16 mm. Amplatzer septal occluder was used to percutaneously close the ASDs (Sharafuddin et al., 1997). Successful implantation of the device was accomplished in 12 (80%) animals. Angiography revealed complete closure of ASD in 7 of 12 animals immediately after device placement and in 11 of 12 one week later. Fibrous incorporation of the device with neoendothelialization was seen within 3 months. The authors concluded that occlusion of

The device has been used widely in PFOs, ASDs, and Fontan fenestrations. The results of first clinical trial were reported by Masura in 1997 (Masura et al., 1997). The device was approved by FDA in December 2001 and has since been used extensively worldwide.

with CardioSEAL device in 50 patients (Pedra et al., 2000).

The disk diameters increase with increasing waist diameters.

Amplatzer device (C) and cribriform Amplatzer device (D).

secundum ASDs is feasible with this new device.

**2.10 Amplatzer septal occluder** 

conjoined ring, the centering mechanism (Rickers et al., 1998). Device sizes ranging from 12 to 40 mm were manufactured. The length of the square of the device determines device size.

ASDs were produced surgically in 20 adult canines. Percutaneous closure was attempted in all and was successful in 19 (95%). Following closure, angiography revealed no shunts in 17 and trivial shunts in 2. Six dogs were followed for 2 to 8 months; trivial shunt present in 1 animal immediately after closure had closed by the time of the repeat study. Device embolization was not seen either at the time of device deployment or during follow-up. Microscopy at 8 weeks in 3 dogs showed the devices to be covered by smooth endocardium, enmeshed in mature collagen tissue. The authors conclude that this self-centering device, with effective and safe ASD closure in a canine model, supports its use in human clinical trials (Das et al., 1993).

Clinical trials were undertaken in US and abroad (Rickers et al., 1998; Banerjee et al., 1999). Phase I clinical trial included 90 patients; 50 of these were ostium secundum ASDs (Banerjee et al., 1999; Das et al., 2003). The ASD size varied between 2 and 20 mm. The device size varied between 18 and 35 mm. The device was successfully implanted in 46 (92%) patients; in the remaining four patients surgical retrieval of the mal-positioned device along with surgical closure of ASD was accomplished without additional complications. Significant procedure related complications were seen in three patients. Follow-up echo studies were available in 34 and in 31 of these, there was no residual shunt. A phase II trial involving 47 patients followed with essentially similar results as those of phase I trials (Das et al., 2003). Prior to the conclusion of phase II trial, the investigation was halted in attempts to reconfigure the device. The new device modification, Guardian Angel wing (Angel wing II) included rounded right and left atrial disks, to be easily retrievable, to be easily repositioned and to maintain the self-centering mechanism. Although it was stated that the re-made device will enter clinical trials in the near future (Das et al., 2003), to our knowledge, there has been no further activity reported of either the Angel Wing or Guardian Angel devices; it would appear that the device was shelved.

#### **2.9 CardioSEAL and STARFlex devices**

As mentioned in the previous section of this paper, following withdrawal of clamshell device because of breakage of arms (stress fractures), the device was redesigned by replacing stainless steel of the umbrella arms with MP35N, a nonferrous alloy and by introducing an additional bend in the arms of the device; the device was named CardioSEAL (Figure 12 C) in 1996 (Ryan et al., 1998). Subsequently the device was modified to introduce self-centering mechanism by attaching micro springs between the umbrellas, and is named STARFlex (Figure 12 D) in 1998 (Hausdorf et al., 1999).

Both CardioSEAL and STARFlex devices were used in the European multicenter trial (Carminati et al., 2000; Bennhagen et al., 2003) conducted from October 1996 to April 1999; device implantation was attempted in 334 patients with success in 325 (97.3%) patients. Device to balloon stretched ASD diameter ratio was 2.16 (mean). Embolization of the device occurred shortly after the procedure in 13 patients (4%); 12 embolized to the pulmonary artery and one to the left ventricle. In ten patients, surgical retrieval and ASD closure was performed while the remaining three had catheter retrieval with successful re-implantation of another device. One patient had hemiplegia four hours after the procedure. A residual shunt was present in 41% immediately following the procedure, which decreased to 31% at time of discharge and to 21% six and 12 months later. During follow-up surgery was required in two more patients and wire frame fractures were observed in 6.1% patients. The authors concludes that these devices are useful to close small to moderate ASDs and when used to close large defects, complications or less than optimal results are likely. Similar results were reported in the Canadian experience with CardioSEAL device in 50 patients (Pedra et al., 2000).

STARFlex was further modified by replacing Dacron with bio-absorbable materials: BioSTAR and BioTREK; these devices will be discussed in a latter section of this paper.

#### **2.10 Amplatzer septal occluder**

70 Atrial Septal Defect

conjoined ring, the centering mechanism (Rickers et al., 1998). Device sizes ranging from 12 to 40 mm were manufactured. The length of the square of the device determines device size. ASDs were produced surgically in 20 adult canines. Percutaneous closure was attempted in all and was successful in 19 (95%). Following closure, angiography revealed no shunts in 17 and trivial shunts in 2. Six dogs were followed for 2 to 8 months; trivial shunt present in 1 animal immediately after closure had closed by the time of the repeat study. Device embolization was not seen either at the time of device deployment or during follow-up. Microscopy at 8 weeks in 3 dogs showed the devices to be covered by smooth endocardium, enmeshed in mature collagen tissue. The authors conclude that this self-centering device, with effective and safe ASD closure in a canine model, supports its use in human clinical

Clinical trials were undertaken in US and abroad (Rickers et al., 1998; Banerjee et al., 1999). Phase I clinical trial included 90 patients; 50 of these were ostium secundum ASDs (Banerjee et al., 1999; Das et al., 2003). The ASD size varied between 2 and 20 mm. The device size varied between 18 and 35 mm. The device was successfully implanted in 46 (92%) patients; in the remaining four patients surgical retrieval of the mal-positioned device along with surgical closure of ASD was accomplished without additional complications. Significant procedure related complications were seen in three patients. Follow-up echo studies were available in 34 and in 31 of these, there was no residual shunt. A phase II trial involving 47 patients followed with essentially similar results as those of phase I trials (Das et al., 2003). Prior to the conclusion of phase II trial, the investigation was halted in attempts to reconfigure the device. The new device modification, Guardian Angel wing (Angel wing II) included rounded right and left atrial disks, to be easily retrievable, to be easily repositioned and to maintain the self-centering mechanism. Although it was stated that the re-made device will enter clinical trials in the near future (Das et al., 2003), to our knowledge, there has been no further activity reported of either the Angel Wing or Guardian Angel devices; it

As mentioned in the previous section of this paper, following withdrawal of clamshell device because of breakage of arms (stress fractures), the device was redesigned by replacing stainless steel of the umbrella arms with MP35N, a nonferrous alloy and by introducing an additional bend in the arms of the device; the device was named CardioSEAL (Figure 12 C) in 1996 (Ryan et al., 1998). Subsequently the device was modified to introduce self-centering mechanism by attaching micro springs between the umbrellas,

Both CardioSEAL and STARFlex devices were used in the European multicenter trial (Carminati et al., 2000; Bennhagen et al., 2003) conducted from October 1996 to April 1999; device implantation was attempted in 334 patients with success in 325 (97.3%) patients. Device to balloon stretched ASD diameter ratio was 2.16 (mean). Embolization of the device occurred shortly after the procedure in 13 patients (4%); 12 embolized to the pulmonary artery and one to the left ventricle. In ten patients, surgical retrieval and ASD closure was performed while the remaining three had catheter retrieval with successful re-implantation of another device. One patient had hemiplegia four hours after the procedure. A residual shunt was present in

and is named STARFlex (Figure 12 D) in 1998 (Hausdorf et al., 1999).

trials (Das et al., 1993).

would appear that the device was shelved.

**2.9 CardioSEAL and STARFlex devices** 

In 1997, a new self-expanding Nitinol prosthesis was developed by Dr. Kurt Amplatz, which consists of two self-expandable round disks connected to each other with a short connecting waist (Sharafuddin et al., 1997) and is commonly referred to as Amplatzer septal occluder (Figure 13 A). Nitinol is a nickel-titanium compound consisting of 55% nickel and 45% titanium and has a property of resuming the original shape (shape memory) when deployed. The device size is determined by the waist diameter and ranges from 4 to 40 mm. The disk diameters increase with increasing waist diameters.

Fig. 13. Photographs of Amplatzer septal occluder (A), PFO Occluder (B), fenestrated Amplatzer device (C) and cribriform Amplatzer device (D).

ASDs were created surgically in 15 mini-pigs; the ASD diameter ranged between 10 and 16 mm. Amplatzer septal occluder was used to percutaneously close the ASDs (Sharafuddin et al., 1997). Successful implantation of the device was accomplished in 12 (80%) animals. Angiography revealed complete closure of ASD in 7 of 12 animals immediately after device placement and in 11 of 12 one week later. Fibrous incorporation of the device with neoendothelialization was seen within 3 months. The authors concluded that occlusion of secundum ASDs is feasible with this new device.

The device has been used widely in PFOs, ASDs, and Fontan fenestrations. The results of first clinical trial were reported by Masura in 1997 (Masura et al., 1997). The device was approved by FDA in December 2001 and has since been used extensively worldwide.

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 73

used. One device embolized into the descending aorta and complete occlusion was noticed in remaining pigs. Follow-up studies revealed that the detachable balloons lost their content and became flat in approximately two months and the device was covered by endothelial tissue in 3 to 4 weeks. Human feasibility study (Sideris et al., 1999a) involved six ostium secundum ASDs (among others); one device embolized, one patient had residual shunt

Fig. 14. Photographs of HELEX device (A), transcatheter patch (B), BioSTAR device

The transcatheter patch device consisted of a flat or sleeve patch, a balloon support catheter and a safety thread; the patch, made up of polyurethane foam, covers the distal balloon. The occluding distal balloon (balloon/patch) is inflated at volumes 2 mm larger than the testoccluding diameter of the defect and held in place. The balloons were deflated and removed 48 hours later. This device was also tried in 20 experimentally created ASDs (Sideris et al., 2000b); ten were flat patches and ten sleeve patches. The patches were supported by balloon catheters from one to six days. Good occlusion of ASDs was seen if the supporting catheter was withdrawn 48 hours or later. Histological studies revealed formation fibrin and inflammatory cells. The sleeve patch appeared to be better centered over the defect than a flat patch. Initial clinical trials were performed in a limited number of patients (Sideris, 2003). Subsequently (Sideris et al., 2010), a larger number (N=74) of patients participated in the clinical trial. The age of the subjects varied from 1.5 to 67 years and their defect sizes were from 13 to 35 mm (mean=25) in diameter; 88% had effective occlusion immediately after deployment of the patch which increased to 96% at follow-up (Sideris et al., 2010).

Initially, this device required keeping the balloon in place up to 48 hours to allow the patch to adhere to the septal wall, an obvious disadvantage of this technique (King & Mills, 2010). To address this problem, Sideris et al (2010) developed accelerated release technique by applying polyethylene glycol-based surgical adhesive to the surface of the patch immediately prior to its implantation. This method was used in 9 patients with ASD diameters ranging from six and 25 mm. Effective occlusion immediately after implantation occurred in 78% which improved to 100% a follow-up. An immediate release patch (IRP)

which increased over time and four had good occlusion.

(C) and BioTREK device (D).

Detailed description of the device, implantation procedure and results were described in Chapter 1 and several other chapters in this book and will not be further discussed. Several modifications of the Amplatzer device were introduced: 1. PFO Occluder (Figure 13 B) to close patent foramen ovale (Han et al., 1999), 2. fenestrated Amplatzer device (Figure 13 C) to keep atrial septal defects or Fontan fenestration open to maintain cardiac output (Amin et al., 2002), restrict the size of defect to reduce the atrial shunt (Holtzer et al., 2005) or to serve as pop-off mechanism in severe pulmonary hypertension (Lammers et al., 2007), 3. cribriform device (Figure 13 D) to occlude multiple or fenestrated ASDs (Hijazi et al 2003) and 4. nanoplatinum coating to prevents nickel release from Amplatzer devices (Lertsapcharoen, 2008), thus preventing Kounis syndrome.

#### **2.11 HELEX septal occluder**

The HELEX septal occluder is made up of a single length of 0.012-in diameter Nitinol wire covered by an ultra thin membrane of ePTFE. The configuration, once delivered to the site of implantation, was two round and flexible disks (Figure 14 A), one on either side of the ASD. During delivery, the flexible frame is elongated around a central mandrel and fits through a 9F sheath. The wire mandrel except for the central locking mechanism is covered with ePTFE membrane so that only a small portion of Nitinol wire is exposed in the vascular system. Several sizes from 15 to 35 mm, in 5 mm increments were manufactured.

Device closure was performed in 24 dogs with surgically created ASDs with 100% successful implantation. Initial occlusion rate of 88% was found by transesophageal echocardiography which improved to l00% at 2-week follow-up (Zahn et al., 1999; 2001). These animal studies also demonstrated coverage of the defect components with fibrous connective tissue followed by neo-endothelialization, usually within three months.

The first clinical implant was performed by in 1999 (Latson et al., 2000), and the Food and Drug Administration phase I feasibility trial began in 2000. Feasibility study involving 63 patients, multicenter pivotal study including 143 subjects and continued access study that enrolled 156 patients (Feldman, 2010) demonstrated feasibility, safety and effectiveness of the device. The HELEX occluder was approved by FDA in 2006 and from then on it has been used extensively worldwide for closing small to medium sized ASDs and PFOs.

#### **2.12 Sideris' Wire-less devices including transcatheter patch**

Majority of ASD-occluding devices are double disc devices with wire components and have limitations. The major disadvantages are requirement of sufficient septal rims to hold the device in place and complications related to wire components (wire fractures and perforations) of the device. To address these problems, Sideris and colleagues developed wireless, transcatheter-implantable devices to occlude large ASDs (Sideris et al., 1999 a & b; Zamora et al., 2000; Sideris, 2003). Two devices were developed (Sideris, 2003): detachable balloon device and the transcatheter patch (Figure 14 B).

The detachable balloon device (DBD) consisted of balloon occluder, made from Latex in different sizes and a floppy disk, similar to the counter occluder described in the buttoned device section above. The DBDs were used to occlude of experimentally created ASDs in 20 piglets (Sideris et al., 2000a); in three experiments detachable double balloon devices were

Detailed description of the device, implantation procedure and results were described in Chapter 1 and several other chapters in this book and will not be further discussed. Several modifications of the Amplatzer device were introduced: 1. PFO Occluder (Figure 13 B) to close patent foramen ovale (Han et al., 1999), 2. fenestrated Amplatzer device (Figure 13 C) to keep atrial septal defects or Fontan fenestration open to maintain cardiac output (Amin et al., 2002), restrict the size of defect to reduce the atrial shunt (Holtzer et al., 2005) or to serve as pop-off mechanism in severe pulmonary hypertension (Lammers et al., 2007), 3. cribriform device (Figure 13 D) to occlude multiple or fenestrated ASDs (Hijazi et al 2003) and 4. nanoplatinum coating to prevents nickel release from Amplatzer devices

The HELEX septal occluder is made up of a single length of 0.012-in diameter Nitinol wire covered by an ultra thin membrane of ePTFE. The configuration, once delivered to the site of implantation, was two round and flexible disks (Figure 14 A), one on either side of the ASD. During delivery, the flexible frame is elongated around a central mandrel and fits through a 9F sheath. The wire mandrel except for the central locking mechanism is covered with ePTFE membrane so that only a small portion of Nitinol wire is exposed in the vascular

Device closure was performed in 24 dogs with surgically created ASDs with 100% successful implantation. Initial occlusion rate of 88% was found by transesophageal echocardiography which improved to l00% at 2-week follow-up (Zahn et al., 1999; 2001). These animal studies also demonstrated coverage of the defect components with fibrous connective tissue

The first clinical implant was performed by in 1999 (Latson et al., 2000), and the Food and Drug Administration phase I feasibility trial began in 2000. Feasibility study involving 63 patients, multicenter pivotal study including 143 subjects and continued access study that enrolled 156 patients (Feldman, 2010) demonstrated feasibility, safety and effectiveness of the device. The HELEX occluder was approved by FDA in 2006 and from then on it has been

Majority of ASD-occluding devices are double disc devices with wire components and have limitations. The major disadvantages are requirement of sufficient septal rims to hold the device in place and complications related to wire components (wire fractures and perforations) of the device. To address these problems, Sideris and colleagues developed wireless, transcatheter-implantable devices to occlude large ASDs (Sideris et al., 1999 a & b; Zamora et al., 2000; Sideris, 2003). Two devices were developed (Sideris, 2003): detachable

The detachable balloon device (DBD) consisted of balloon occluder, made from Latex in different sizes and a floppy disk, similar to the counter occluder described in the buttoned device section above. The DBDs were used to occlude of experimentally created ASDs in 20 piglets (Sideris et al., 2000a); in three experiments detachable double balloon devices were

system. Several sizes from 15 to 35 mm, in 5 mm increments were manufactured.

used extensively worldwide for closing small to medium sized ASDs and PFOs.

followed by neo-endothelialization, usually within three months.

**2.12 Sideris' Wire-less devices including transcatheter patch** 

balloon device and the transcatheter patch (Figure 14 B).

(Lertsapcharoen, 2008), thus preventing Kounis syndrome.

**2.11 HELEX septal occluder** 

used. One device embolized into the descending aorta and complete occlusion was noticed in remaining pigs. Follow-up studies revealed that the detachable balloons lost their content and became flat in approximately two months and the device was covered by endothelial tissue in 3 to 4 weeks. Human feasibility study (Sideris et al., 1999a) involved six ostium secundum ASDs (among others); one device embolized, one patient had residual shunt which increased over time and four had good occlusion.

Fig. 14. Photographs of HELEX device (A), transcatheter patch (B), BioSTAR device (C) and BioTREK device (D).

The transcatheter patch device consisted of a flat or sleeve patch, a balloon support catheter and a safety thread; the patch, made up of polyurethane foam, covers the distal balloon. The occluding distal balloon (balloon/patch) is inflated at volumes 2 mm larger than the testoccluding diameter of the defect and held in place. The balloons were deflated and removed 48 hours later. This device was also tried in 20 experimentally created ASDs (Sideris et al., 2000b); ten were flat patches and ten sleeve patches. The patches were supported by balloon catheters from one to six days. Good occlusion of ASDs was seen if the supporting catheter was withdrawn 48 hours or later. Histological studies revealed formation fibrin and inflammatory cells. The sleeve patch appeared to be better centered over the defect than a flat patch. Initial clinical trials were performed in a limited number of patients (Sideris, 2003). Subsequently (Sideris et al., 2010), a larger number (N=74) of patients participated in the clinical trial. The age of the subjects varied from 1.5 to 67 years and their defect sizes were from 13 to 35 mm (mean=25) in diameter; 88% had effective occlusion immediately after deployment of the patch which increased to 96% at follow-up (Sideris et al., 2010).

Initially, this device required keeping the balloon in place up to 48 hours to allow the patch to adhere to the septal wall, an obvious disadvantage of this technique (King & Mills, 2010). To address this problem, Sideris et al (2010) developed accelerated release technique by applying polyethylene glycol-based surgical adhesive to the surface of the patch immediately prior to its implantation. This method was used in 9 patients with ASD diameters ranging from six and 25 mm. Effective occlusion immediately after implantation occurred in 78% which improved to 100% a follow-up. An immediate release patch (IRP)

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 75

TEE studies showed a residual shunt in 11.2% after 60 days in patients with PFO and a leftto-right shunt in 9.1% of the remaining patients with ASD. After 180 days only 1 patient (3.7%) with PFO had a right-to-left shunt. No residual shunts were observed in the patients

PFO-Star device, consisting of Ivalon foam double umbrella was developed in late 1990s by Cardia Inc. (Eagan, MN) for percutaneous closure of PFOs (Braun et al., 2002; Schraeder et al, 2003). This device may be considered Generation I and was modified several times, addressing its deficiencies with resultant development of Generation II, Generation III, Generation IV (INTRASEPT), Generation V (ATRIASEPT I-ASD and ATRIASEPT II-ASD) and Generation VI (ULTRASEPT) devices (Turner & Forbes, 2010). Generation V and VI devices were designed to deal with ostium secundum ASDs. Clinical trials with ATRIASEPT I-ASD device (Stolt et al., 2010; Turner & Forbes, 2010) showed favorable early results. Clinical trials with ATRIASEPT

The Solysafe Septal Occluder device (Swissimplant AG, Solothurn, Switzerland), designed by Dr. Lazlo Solymar of Gothenburg, consists of two foldable polyester patches attached to eight cobalt-based alloy (Phynox) wires. The course of the wires through the patches enables the device to center itself within the defect. The maximum diameter is given by the distance of the wires that are fixed in the patches. Several sizes, 25 mm thru' 44 mm are manufactured (Ewert, 2010). Two clinical trials with 44 and 32 patients (Ewert et al., 2008, Kretschmar et al., 2010) respectively were reported with implantation rates of 87% and closure rate of 100% at six month follow-up. The worldwide experience with this device was

The pfm ASD-R devices were made up of tightly woven single piece of Nitinol wire mesh without welding or hubs and in their final form have a double-disc configuration. Animal experimentation in pigs revealed complete endothelialization in three weeks without significant inflammatory reaction (Granja & Freudenthal, 2010). The initial clinical application in 23 patients demonstrated good results and a multi-institutional phase II

Other devices such as Cardi-O-Fix Septal Occluder, Heart R Septal Occluder, cocoon, Lifetech device (also called sears device), some manufactured in China and others that may

Some cerebrovascular accidents and other systemic arterial emboli, especially in young subjects are presumed to be due to paradoxical embolism through an atrial defect, most

**2.13.3 Cardia devices (INTRASEPT, ATRIASEPT I/II-ASD and ULTRASEPT)** 

II-ASD and ULTRASEPT devices are planned (Turner & Forbes, 2010).

clinical trial in Argentina is planned (Granja & Freudenthal, 2010).

have escaped detection by our literature search may be in development.

with ASD (Krizanic et al., 2010).

**2.13.4 Solysafe septal occluder** 

**2.13.5 The pfm ASD-R device** 

**2.13.6 Other devices** 

**3. Closure of patent foramen ovale** 

said to approximate 1,400 patients (Ewert, 2010).

was developed which uses a single latex balloon, a safety bioabsorbable thread (Vicryl, Ethicon, a Johnson & Johnson company, Somerville, NJ) and polyurethane patch with surgical adhesive that was used in accelerated release technique. The addition of the adhesive makes the device release immediate and attachment to the septum (mediated by fibrin formation) takes place in approximately 48 hours (Sideris et al., 2010). The IRP was used in 10 subjects with defects ranging from 12 to 26 mm; 100% full occlusion both at implantation and at follow-up was reported (Sideris et al., 2010). Further clinical trials are planned.

#### **2.13 New devices**

Subsequent to the development of the devices reviewed in the preceding sections additional devices were designed and tested. None of these are approved by the FDA for routine clinical use and will be reviewed briefly.

These devices, to the best of our knowledge, are bio-absorbable NMT devices (Bio-STAR and Bio-TREK), Occlutech device, Cardia devices (INTRASEPT, ATRIASEPT I/II-ASD and ULTRASEPT), Solysafe Septal Occluder, pfm ASD-R device, Heart R Septal Occluder (manufactured in China) and others.

#### **2.13.1 BioSTAR and BioTREK**

When occluding devices are implanted to close ASDs, the left atrium is essentially inaccessible, should trans-septal intervention becomes necessary later in life such as mapping and ablation of left-sided accessory pathways, mitral valve interventions, left atrial appendage occlusion and others. To address this concern, NMT Medical Inc. (Boston, MA) modified the STARFlex device by replacing Dacron with heparin-coated, acellular, tissue engineered, porcine intestinal collagen matrix that allows absorption and replacement of the membrane with human tissue, and was named BioSTAR (Figure 14C). Studies in sheep model (Jux et al., 2003; 2006) demonstrated rapid endothelialization of the device and resorption of intestinal collagen matrix over a period of 2 years. Feasibility, safety, and effectiveness of closure of ASDs with BioSTAR both in adults (Mullen et al., 2006) and children (Hoehn et al., 2010) were demonstrated.

The supporting arms (ribs) of the BioSTAR device however, continue to be metallic and are not bio-absorbable. BioTREK device (Figure 14 D) was developed and designed to be 100% reabsorbable. The covering discs as well as support ribs are made up of poly-4 hydroxybutyrate. Over time, the patches and the connecting ribs disappear, leaving the fibrous septum. The device was reported in preclinical testing (Kramer, 2010). Other workers are developing additional biodegradable devices (Duong-Hong et al., 2010).

#### **2.13.2 Occlutech**

Occlutech septal occluder, initially designed to close PFOs (Krizanic et al. 2008) has been modified to close ASDs. The device is similar to Amplatzer in design (double-disc device composed of self-expanding Nitinol mesh wire), but with use of unique braiding technology; the amount of metal is reduced by 50%. In addition, the left atrial hub is removed. The devices were implanted in 29 patients with PFO and in 12 patients with ASD. TEE studies showed a residual shunt in 11.2% after 60 days in patients with PFO and a leftto-right shunt in 9.1% of the remaining patients with ASD. After 180 days only 1 patient (3.7%) with PFO had a right-to-left shunt. No residual shunts were observed in the patients with ASD (Krizanic et al., 2010).

#### **2.13.3 Cardia devices (INTRASEPT, ATRIASEPT I/II-ASD and ULTRASEPT)**

PFO-Star device, consisting of Ivalon foam double umbrella was developed in late 1990s by Cardia Inc. (Eagan, MN) for percutaneous closure of PFOs (Braun et al., 2002; Schraeder et al, 2003). This device may be considered Generation I and was modified several times, addressing its deficiencies with resultant development of Generation II, Generation III, Generation IV (INTRASEPT), Generation V (ATRIASEPT I-ASD and ATRIASEPT II-ASD) and Generation VI (ULTRASEPT) devices (Turner & Forbes, 2010). Generation V and VI devices were designed to deal with ostium secundum ASDs. Clinical trials with ATRIASEPT I-ASD device (Stolt et al., 2010; Turner & Forbes, 2010) showed favorable early results. Clinical trials with ATRIASEPT II-ASD and ULTRASEPT devices are planned (Turner & Forbes, 2010).

#### **2.13.4 Solysafe septal occluder**

74 Atrial Septal Defect

was developed which uses a single latex balloon, a safety bioabsorbable thread (Vicryl, Ethicon, a Johnson & Johnson company, Somerville, NJ) and polyurethane patch with surgical adhesive that was used in accelerated release technique. The addition of the adhesive makes the device release immediate and attachment to the septum (mediated by fibrin formation) takes place in approximately 48 hours (Sideris et al., 2010). The IRP was used in 10 subjects with defects ranging from 12 to 26 mm; 100% full occlusion both at implantation and at follow-up was reported (Sideris et al., 2010). Further clinical trials are

Subsequent to the development of the devices reviewed in the preceding sections additional devices were designed and tested. None of these are approved by the FDA for routine

These devices, to the best of our knowledge, are bio-absorbable NMT devices (Bio-STAR and Bio-TREK), Occlutech device, Cardia devices (INTRASEPT, ATRIASEPT I/II-ASD and ULTRASEPT), Solysafe Septal Occluder, pfm ASD-R device, Heart R Septal Occluder

When occluding devices are implanted to close ASDs, the left atrium is essentially inaccessible, should trans-septal intervention becomes necessary later in life such as mapping and ablation of left-sided accessory pathways, mitral valve interventions, left atrial appendage occlusion and others. To address this concern, NMT Medical Inc. (Boston, MA) modified the STARFlex device by replacing Dacron with heparin-coated, acellular, tissue engineered, porcine intestinal collagen matrix that allows absorption and replacement of the membrane with human tissue, and was named BioSTAR (Figure 14C). Studies in sheep model (Jux et al., 2003; 2006) demonstrated rapid endothelialization of the device and resorption of intestinal collagen matrix over a period of 2 years. Feasibility, safety, and effectiveness of closure of ASDs with BioSTAR both in adults (Mullen et al., 2006) and

The supporting arms (ribs) of the BioSTAR device however, continue to be metallic and are not bio-absorbable. BioTREK device (Figure 14 D) was developed and designed to be 100% reabsorbable. The covering discs as well as support ribs are made up of poly-4 hydroxybutyrate. Over time, the patches and the connecting ribs disappear, leaving the fibrous septum. The device was reported in preclinical testing (Kramer, 2010). Other

Occlutech septal occluder, initially designed to close PFOs (Krizanic et al. 2008) has been modified to close ASDs. The device is similar to Amplatzer in design (double-disc device composed of self-expanding Nitinol mesh wire), but with use of unique braiding technology; the amount of metal is reduced by 50%. In addition, the left atrial hub is removed. The devices were implanted in 29 patients with PFO and in 12 patients with ASD.

workers are developing additional biodegradable devices (Duong-Hong et al., 2010).

planned.

**2.13 New devices** 

**2.13.2 Occlutech** 

clinical use and will be reviewed briefly.

(manufactured in China) and others.

children (Hoehn et al., 2010) were demonstrated.

**2.13.1 BioSTAR and BioTREK** 

The Solysafe Septal Occluder device (Swissimplant AG, Solothurn, Switzerland), designed by Dr. Lazlo Solymar of Gothenburg, consists of two foldable polyester patches attached to eight cobalt-based alloy (Phynox) wires. The course of the wires through the patches enables the device to center itself within the defect. The maximum diameter is given by the distance of the wires that are fixed in the patches. Several sizes, 25 mm thru' 44 mm are manufactured (Ewert, 2010). Two clinical trials with 44 and 32 patients (Ewert et al., 2008, Kretschmar et al., 2010) respectively were reported with implantation rates of 87% and closure rate of 100% at six month follow-up. The worldwide experience with this device was said to approximate 1,400 patients (Ewert, 2010).

#### **2.13.5 The pfm ASD-R device**

The pfm ASD-R devices were made up of tightly woven single piece of Nitinol wire mesh without welding or hubs and in their final form have a double-disc configuration. Animal experimentation in pigs revealed complete endothelialization in three weeks without significant inflammatory reaction (Granja & Freudenthal, 2010). The initial clinical application in 23 patients demonstrated good results and a multi-institutional phase II clinical trial in Argentina is planned (Granja & Freudenthal, 2010).

#### **2.13.6 Other devices**

Other devices such as Cardi-O-Fix Septal Occluder, Heart R Septal Occluder, cocoon, Lifetech device (also called sears device), some manufactured in China and others that may have escaped detection by our literature search may be in development.

#### **3. Closure of patent foramen ovale**

Some cerebrovascular accidents and other systemic arterial emboli, especially in young subjects are presumed to be due to paradoxical embolism through an atrial defect, most

Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 77

[2] Arora, R.; Trehan, V. K.; Karla, G. S.; et al. (1996). Transcatheter closure of atrial septal

[3] Babic, U. (2000). Experience with ASDOS for transcatheter closure of atrial septal defect and patent foramen ovale. *Curr Intervent Cardiol Rep,* Vol. 2, No. 2, pp. 177-183 [4] Babic, U. U.; Grujicic. S.; Popvic, Z.; et al. (1991). Double-umbrella device for transvenous

[5] Babic, U.; Sievert, H.; Schneider, M.; Babic, M. (2003). ASDOS-Atrial Septal Defect

[6] Banerjee, A.; Bengur, A. R.; Li, J. S.; et al. (1999). Echocardiographic characteristics of

[7] Beekman, R. H.; Rocchini, A. P.; Snider, A. R.; et al. (1989). Transcatheter atrial septal

[8] Bennhagen, R. G.; McLaughlin, P., Benson, L. N. (2003). CARDIOSEAL AND STARFLEX

[9] Bigelow, W. G.; Lindsey, W. E. & Greenwood, W. F. (1950). Hypothermia, it's possible

[10] Boutin, C.; Musewe, N. N.; Smallhorn, J. F.; et al. (1993). Echocardiographic follow- up

[11] Braun, M. U.; Fassbender, D.; Schoen, S. P.; et al. (2002). Transcatheter closure of patent

[12] Bridges, N. D.; Hellenbrand, W.; Latson, L.; et al. (1992). Transcatheter closure of patent

[13] Carminati, M.; Giusti, S.; Hausdorf, G.; et al. (2000). A European multicentre experience

[14] Chandar, J. S. ; Rao, P. S. ; Lloyd, T. R. ; et al. (1999). Atrial septal defect closure with 4th

[15] Das, G. S.; Harrison, J. K. & O'Laughlin, M. P. (2003). The Angel Wings Das device. In:

role in cardiac surgery. *Ann Surg,* Vol. 132, No. 5, pp. 849-866

*J Intervent Cardiol, Vol.* 4, No. 4, pp. 283-294

*Intervent Cardiol, Vol. 2, No.* 1, pp. 35-41

Vol. 88, No. 2, pp. 621-627

Philadelphia, PA, USA

pp. 2019-2025

1902-1908

526

Williams & Wilkins, Philadelphia, PA, USA.

(Abstract). *Circulation,* Vol. 100, Suppl - I-708

Lippincott, Williams & Wilkins, Philadelphia, PA, USA.

145-149

1236-1241

defect using buttoned device: Indian experience. *Indian Heart J,* Vol. 48, No.2, pp.

closure of patent ductus arteriosus and atrial septal defect: first clinical experience.

Occluder System, In: *Catheter Based Devices for Treatment of Noncoronary Cardiovascular Disease in Adults and Children,* P. S. Rao, M. J. Kern (Eds.): 35-43,

successful deployment of the Das Angel Wings atrial septal defect closure device: initial multicenter experience in the United States. *Am J Cardiol, Vol.* 83, No. 8, pp.

defect closure: preliminary experience with the Rashkind occluder device. *J* 

DEVICES, In: *Catheter Based Devices for Treatment of Noncoronary Cardiovascular Disease in Adults and Children,* P. S. Rao & M. J. Kern (Eds.): 61-69, Lippincott,

of atrial septal defect after catheter closure by double-umbrella device. *Circulation,* 

foramen ovale in patients with cerebral ischemia. *J Am Coll Cardiol,* Vol. 39, No. 12,

foramen ovale after presumed paradoxical embolism. *Circulation,* Vol. 86, No. 6, pp.

using the CardioSEAL® and Starflex double umbrella devices to close interatrial communications holes within the oval fossa. Cardiol Young, Vol. 10, No. 5, pp. 519-

generation buttoned device: results of US multicenter FDA Phase II clinical trial

*Catheter based devices for the treatment of non-coronary cardiovascular disease in adults and children.* P. S. Rao & M. J. Kern (Eds): 45-49, Lippincott Williams & Wilkins,

frequently a patent foramen ovale (PFO). Closure of such atrial defects is an alternative option to life-long anticoagulation. Non-surgical transcatheter occlusion of such a defect was first reported with King's device in 1976 (Mills & King, 1976). Mills and King effectively occluded an atrial defect with a 25 mm device in a 17-year-old male who had a hemiperetic stroke secondary to paradoxical embolism. Subsequently, clamshell (Bridges et al., 1992) and buttoned (Rao et al., 1992 a & b; Chandar et al., 1996; Ende et al., 1996) devices have been used to successfully occlude PFOs presumed to be the site of paradoxical embolism.

In addition, some PFOs are considered to be the seat of right to left shunt causing hypoxemia as seen in platypnea-orthodeoxia syndrome. Right to left shunt thru' PFO can also occur in patients who were previously treated for complex congenital cardiac anomalies including Fontan fenestrations as well as in patients who had right ventricular infarction. Decompression (Caisson's) illness and migraine have also been attributed to right to left shunt across PFO.

Majority of the ASD devices described in the preceding sections, as and when they became available, have also been used to close PFOs to address the above listed conditions. Moreover, either the existing devices were modified to address the anatomic features of the foramen ovale or new devices were designed to specifically address the PFOs and these include, Amplatzer PFO occluder, Cardia devices (PFO-Star and several of its subsequent generations), Premere occluder, Coherex Flat stent, PFx Closure System (not a device but employs monopolar radio frequency energy to effect closure of a PFO by welding the tissues of the septum primum with the septum secundum), pfm PFO-R, Solysafe PFO occluder and others. Because of limitation in space and the intent to mainly address history of ASD device closure, no further discussion of PFOs will be included.

#### **4. Summary and conclusion**

In this chapter, historical aspects of transcatheter atrial septal occluding devices are reviewed. Since the initial description of an ASD closing devices by King, Rashkind and their associates, a large number of single disc and double disc devices have been designed

and tested in animal models followed by clinical trials in human subjects. Feasibility, safety and effectiveness have been demonstrated with most devices. However, design, redesign, testing and re-testing have been the typical path with most devices. Currently, only two devices are approved by the FDA in the US and these are: Amplatzer septal occluder and HELEX septal occluder. Several other devices are in development, some at the stage of animal experimentation and some in clinical trials in Europe or US. We will await for additional devices to be approved for general clinical use so that the practicing interventional cardiologist will have several devices at his/her disposal so that an appropriate device that suits best for a given patient and his/her defect. A brief review of historical aspects of PFO closure was also included.

#### **5. References**

[1] Amin, Z.; Danford, D. A.; Pedra, C. A. (2002). A new Amplatzer device to maintain patency of Fontan fenestrations and atrial septal defects. *Catheter Cardiovasc Interv*, Vol. 57, No. 2, pp. 246-251

frequently a patent foramen ovale (PFO). Closure of such atrial defects is an alternative option to life-long anticoagulation. Non-surgical transcatheter occlusion of such a defect was first reported with King's device in 1976 (Mills & King, 1976). Mills and King effectively occluded an atrial defect with a 25 mm device in a 17-year-old male who had a hemiperetic stroke secondary to paradoxical embolism. Subsequently, clamshell (Bridges et al., 1992) and buttoned (Rao et al., 1992 a & b; Chandar et al., 1996; Ende et al., 1996) devices have been

In addition, some PFOs are considered to be the seat of right to left shunt causing hypoxemia as seen in platypnea-orthodeoxia syndrome. Right to left shunt thru' PFO can also occur in patients who were previously treated for complex congenital cardiac anomalies including Fontan fenestrations as well as in patients who had right ventricular infarction. Decompression (Caisson's) illness and migraine have also been attributed to right to left

Majority of the ASD devices described in the preceding sections, as and when they became available, have also been used to close PFOs to address the above listed conditions. Moreover, either the existing devices were modified to address the anatomic features of the foramen ovale or new devices were designed to specifically address the PFOs and these include, Amplatzer PFO occluder, Cardia devices (PFO-Star and several of its subsequent generations), Premere occluder, Coherex Flat stent, PFx Closure System (not a device but employs monopolar radio frequency energy to effect closure of a PFO by welding the tissues of the septum primum with the septum secundum), pfm PFO-R, Solysafe PFO occluder and others. Because of limitation in space and the intent to mainly address history of ASD device

In this chapter, historical aspects of transcatheter atrial septal occluding devices are reviewed. Since the initial description of an ASD closing devices by King, Rashkind and their associates, a large number of single disc and double disc devices have been designed and tested in animal models followed by clinical trials in human subjects. Feasibility, safety and effectiveness have been demonstrated with most devices. However, design, redesign, testing and re-testing have been the typical path with most devices. Currently, only two devices are approved by the FDA in the US and these are: Amplatzer septal occluder and HELEX septal occluder. Several other devices are in development, some at the stage of animal experimentation and some in clinical trials in Europe or US. We will await for additional devices to be approved for general clinical use so that the practicing interventional cardiologist will have several devices at his/her disposal so that an appropriate device that suits best for a given patient and his/her defect. A brief review of

[1] Amin, Z.; Danford, D. A.; Pedra, C. A. (2002). A new Amplatzer device to maintain

patency of Fontan fenestrations and atrial septal defects. *Catheter Cardiovasc Interv*,

closure, no further discussion of PFOs will be included.

historical aspects of PFO closure was also included.

Vol. 57, No. 2, pp. 246-251

**4. Summary and conclusion** 

used to successfully occlude PFOs presumed to be the site of paradoxical embolism.

shunt across PFO.

**5. References** 


Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 79

[31] Hijazi, Z. M. & Cao, Q-L. (2003). Transcatheter closure of multi-fenestrated atrial septal

[32] Hoehn, R.; Hesse, C.; Ince, H. & Peuster, M. (2010). First experience with the BioSTAR-

[33] Justo, R. N.; Nykanen, D. G.; Boutin, C.; et al. (1996). Clinical impact of transcatheter

[34] Jux, C.; Bertram, H.; Wohlsein, P.; et al. (2006). Interventional atrial septal defect closure

[36] King, T. D. & Mills, N. L. (1974). Nonoperative closure of atrial septal defects. *Surgery*,

[37] King, T. D.; Thompson, S. L.; Steiner, C.; et al. (1976). Secundum atrial septal defect:

[38] King, T. D.; Thompson, S. L.; Steiner, C.; et al. (1978). Measurement of atrial septal

[39] King, T. D & Mills, N. L. (2010). Historical perspectives on ASD device closure. In:

[40] Kramer, P. (2010). The CardioSEAL/STARFlex family of devices for closure of atrial

[41] Kretschmar, O.; Sglimbea, A.; Daehnert, I.; et al. (2010). Interventional closure of atrial

[42] Krizanic, F.; Krizanic, F.; Sievert, H.; et al. (2010). The Occlutech Figulla PFO and ASD

[43] Krizanic, F.; Sievert, H.; Pfeiffer, D.; et al.( 2008). Clinical evaluation of a novel occluder

[44] Krizanic, F.; Sievert, H.; Pfeiffer, D.; et al. (2010).The Occlutech Figulla PFO and ASD

[45] 45. Lammers, A. E.; Derrick, G.; Haworth, S. G.; et al. (2007). Efficacy and long-term

*Catheter Cardiovasc Interv,* Vol. 75, No. 1, pp. 72-77

occlusion. *J Interv Cardiol,* Vol. 16, No. 2, pp. 149-52

*Cardiol,* Vol. 77, No. 10, pp. 889-892

Vol. 75, No. 3, pp. 383-388

Vol. 41, No. 3, pp. 537-542

Minneapolis, MN, USA

Cardiotext, Minneapolis, MN, USA

*J Cardiol,* Vol. 143, No. 3, pp. 373-377

*Invasive Cardiol,* Vol. 22, No. 4, pp. 182–187

Invasive Cardiol, Vol. 22, No. 4, pp. 182-187

Vol. 70, No. 4, pp. 578-584

(PFO). *Clin Res Cardiol,* Vol. 97, No. 12, pp. 872- 877

25, pp. 2506-2509

Vol. 1, No. 1, pp. 1-4

defects using the new Amplatzer cribriform device. *Congenital Cardiology Today,* 

device for various applications in pediatric patients with congenital heart disease.

closure of secundum atrial septal defects with double umbrella device. *Am J* 

using a totally bioresorbable occluder matrix: development and preclinical evaluation of the BioSTAR device. *J Amer Coll Cardiol,* Vol. 48, No. 1, pp. 161-169 [35] Jux, C.; Wohlsein, P.; Bruegmann, M.; et al. (2003). A new biological matrix for septal

nonoperative closure during cardiac catheterization. *J Am Med Assoc, Vol.* 235, No.

defect during cardiac catheterization: experimental and clinical trials. *Am J Cardiol,*

*Transcatheter closure of ASDs and PFOs: A comprehensive assessment,* Z. M. Hijazi, T. Feldman, M. H. Abdullah A Al-Qbandi, & H. Sievert (Eds): 423-429, Cardiotext,

level defects. In: *Transcatheter closure of ASDs and PFOs: A comprehensive assessment,*  Z. M. Hijazi, T. Feldman, M. H. Abdullah A Al-Qbandi, & H. Sievert (Eds): 483-399,

septal defects with the Solysafe Septal Occluder--preliminary results in children. *Int* 

Occluder: A New Nitinol Wire Mesh Device for Closure of Atrial Septal Defects. *J* 

device (Occlutech) for percutaneous transcatheter closure of patent foramen ovale

occluder: a new nitinol wiremesh device for closure of atrial septal defects. J

patency of fenestrated Amplatzer devices in children. *Catheter Cardiovasc Interv,* 


[16] Das, G. S.; Voss, G.; Jarvis, G.; et al. (1993). Experimental atrial septal defect closure with

[17] Duong-Hong, D.; Tang, Y. D. & Wu, W. (2010). Fully biodegradable septal defect

[18] Ende, D. J.; Chopra, P. S. & Rao, P. S. (1996). Prevention of recurrence of paradoxic

[19] Ewert, P. (2010). The Solysafe septal occluder for the closure of ASDs and PFOs. In:

[20] Ewert, P.; Soderberg, B.; Dahnert, I.; et al. (2008). ASD and PFO closure with the

[21] Feldman, T. (2010). The GORE HELEX septal occluder. In: *Transcatheter closure of ASDs* 

Al-Qbandi, & H. Sievert (Eds): 355-368, Cardiotext, Minneapolis, MN, USA [22] Galal, M. O.; Wobst, A.; Halees, Z.; et al. (1994). Perioperative complications following

[23] Gibbon, J. H., Jr. (1953) Application of a mechanical heart and lung apparatus to cardiac

[24] Granja, M. & Freudenthal, F. (2010). The pfm device for ASD closure. In: *Transcatheter* 

[25] Haddad, J.; Secches, A.; Finzi, L.; et al. (1996). Atrial septal defect: percutaneous

[26] Han, Y. ; Gu, X. ; Titus, J. L. ; et al. (1999). New self-expanding patent foramen ovale occlusion device. *Cathet Cardiovasc Intervent,* Vol. 47, No. 3, pp. 370-376 [27] Holzer, R.; Cao, Q. L. & Hijazi, Z. M. (2005). Closure of a moderately large atrial septal

[28] Hausdorf, G.; Kaulitz. R. & Paul T. (1999). Transcatheter closure of atrial septal defect

[29] Hausdorf, G.; Schneider, M.; Franzbach, B.; et al. (1996). Transcatheter closure of

(ASDOS): initial experience in children. Heart, Vol. 75, No. 1, pp. 83-88 [30] Hellenbrand, W. E.; Fahey, J. T.; McGowan, F. X.; et al. (1990). Transesophageal

(ed): 107-113, University of Minnesota, Minneapolis, MN, USA

buttoned device. *Am J Cardiol, Vol.* 78, No. 2, pp. 233-236

*Cardiovasc Intervent,* Vol. 71, No. 3, pp. 398-402

*Europ Heart J,* Vol. 15, No. 10, pp. 1381-1384

*Interv,* Vol. 64, No. 4, pp. 513-518

*Cardiol,* Vol. 66, No. 2, pp. 207-213

84, No. 9, pp. 1113-1116

711-718

USA

17-22

Minneapolis, MN, USA

a new, transcatheter, self-centering device. *Circulation, Vol.* 88, No. 4, pp. 1754-1764

occluder-a double umbrella design. *Catheter Cardiovasc Interv,* Vol. 76, No. 5, pp.

embolism: mid-term follow-up after transcatheter closure of atrial defects with

*Transcatheter closure of ASDs and PFOs: A comprehensive assessment,* Z. M. Hijazi, T. Feldman, M. H. Abdullah A Al-Qbandi, & H. Sievert (Eds): 417-422, Cardiotext,

Solysafe septal occluder-Results of a prospective multicenter pilot study. *Cathet*

*and PFOs: A comprehensive assessment,* Z. M. Hijazi, T. Feldman, M. H. Abdullah A

surgical closure of atrial septal defect type II in 232 patients - a baseline study.

surgery. In: *Recent Advances in Cardiovascular Physiology and Surgery,* J. H. Gibbon, Jr

*closure of ASDs and PFOs: A comprehensive assessment.* Z. M Hijazi, T. Feldman, M. H. Abdullah A Al-Qbandi, & H. Sievert (Eds): 423-429, Cardiotext, Minneapolis, MN,

transvenous occlusion with the buttoned device. *Arq Bras Cardiol,* Vol. 67, No. 1, pp.

defect with a self-fabricated fenestrated Amplatzer septal occluder in an 85- yearold patient with reduced diastolic elasticity of the left ventricle. *Catheter Cardiovasc* 

with a new flexible, self-centering device, The Starflex Occluder. *Am Heart J,* Vol.

secundum atrial septal defects with the atrial septal defect occlusion system

echocardiographic guidance of transcatheter closure of atrial septal defect. *Am J* 


Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 81

[62] Prieto, L. R.; Foreman, C. K.; Cheatham, J. P.; et al. (1996). Intermediate-term outcome of

[63] Rao, P. S. Buttoned Device. (2003) In: *Catheter based devices for the treatment of non-*

[64] Rao, P. S.; Berger, F.; Rey, C.; et al. (2000). Transvenous occlusion of secundum atrial

[65] Rao, P. S.; Chander, J. S. & Sideris, E. B. (1997). Role of inverted buttoned device in

[66] Rao, P. S. Ende, D. J.; Wilson, A. D.; et al. (1995). Follow-up results of transcatheter

[67] Rao, P. S.; Palacios, I. F.; Bach, R. G.; et al. (2001). Platypnea- Orthodeoxia Syndrome:

[68] Rao, P. S. & Sideris, E. B. (1995). Transcatheter occlusion of cardiac defects [letter].*Br* 

[69] Rao, P. S. & Sideris, E. B. (1998). Buttoned device closure of the atrial septal defect. *J* 

[70] Rao, P. S. & Sideris, E. B. (2001). Centering-on-demand buttoned device: Its role in

[71] Rao, P. S.; Sideris, E. B. & Chopra, P. S. (1991). Catheter closure of atrial septal defect: successful use in a 3.6 kg infant. *Am Heart J,* Vol. 121, No. 6, pp. 1826-1829 [72] Rao, P. S.; Sideris, E. B.; Haddad, J.; et al. (1993). Transcatheter occlusion of patent

[73] Rao, P. S.; Sideris, E. B.; Hausdorf, G.; et al. (1994). International experience with

[74] Rao, P. S.; Sideris, E. B.; Rey, C.; et al. (1998). Echo-Doppler follow-up evaluation after

Imai & K. Momma (Eds): 197-200, Futura Publishing Co, Armonk, NY, USA [75] Rao, P. S.; Wilson, A. D.; Levy, J. M.; et al. (1992a). Role of "buttoned" double-disc

[76] Rao, P. S, Wilson, A. D.; Chopra, P. S. (1992b). Transcatheter closure of atrial septal defects by "buttoned" devices. *Am J Cardiol,* Vol. 69, No. 12, pp. 1056-1061 [77] Rashkind, W. J. (1975). Experimental transvenous closure of atrial and ventricular septal

3rd generation devices. *J Am Coll Cardiol, Vol.* 36, No. 2, pp. 583-592

umbrella. *Am J Cardiol,* Vol. 78, No. 11, pp. 1310-1312

anomalies. *Am J Cardiol,* Vol. 80, No. 7, pp. 914-921

*Interventional Cardiol, Vol.* 11, No. 5, pp. 467-484

*Circulation,* Vol. 88, No. 3, pp. 1119-1126

defects. *Circulation,* Vol. 52, Suppl-II-8

128, No. 5, pp. 1022-1035

*Intervent,* Vol. 54, No. 1, pp. 77-82

*Heart J,* Vol. 73, No. 6, pp. 585-586

pp. 695-701

81-89

191-200

34, Lippincott Williams & Wilkins, Philadelphia, PA, USA

transcatheter secundum atrial septal defect closure using Bard clamshell septal

*coronary cardiovascular disease in adults and children,* P. S. Rao & M. J. Kern (Eds): 17-

septal defects with 4th generation buttoned device: comparison with 1st, 2nd and

transcatheter occlusion of atrial septal defects or patent foramen ovale with rightto-left shunting associated with previously operated complex congenital cardiac

occlusion of atrial septal defects with buttoned device. *Cand J Cardiol, Vol.* 11, No. 8,

Management by Transcatheter Buttoned Device Implantation. *Cathet Cardiovasc* 

transcatheter occlusion of atrial septal defects. *J Intervent Cardiol,* Vol. 14, No. 1, pp.

ductus arteriosus with adjustable buttoned device: initial clinical experience.

secundum atrial septal defect occlusion by the buttoned device. *Am Heart J,* Vol.

transcatheter occlusion of atrial septal defects with the buttoned device. In: *Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery,* Y.

device in the management of atrial septal defects. *Am Heart J,* Vol. 123, No. 1, pp.


[46] Latson, L. A. (1993). Transcatheter closure of atrial septal defects. In: *Transcatheter*

[47] Latson, L.; Zahn, E. & Wilson N. (2000). HELEX septal occluder for closure of atrial

[48] Lertsapcharoen, P.; Khongphatthanayothin, A.; Srimahachota, S. & Leelanukrom, R.

[49] Lewis, F. J. & Tauffic, M. (1953). Closure of atrial septal defects with the aid of

[50] Lloyd, T. R.; Rao, P. S.; Beekman, R. H., III.; et al. (1994). Atrial septal defect occlusion

[51] Lock, J. E. ; Cockerham J. T.; Keane, J. F.; et al. (1987). Transcatheter umbrella closure of

[52] Lock, J. E. ; Rome, J. J.; Davis, R.; et al. (1989). Transcatheter closure of atrial septal defects: experimental studies. *Circulation,* Vol. 79, No. 5, pp. 1091-1099 [53] Masura, J.; Gavora, P.; Formanek, A. & Hijazi, Z. M. (1997). Transcatheter closure of

[54] Mills, N. L. & King, T. D. (1976). Nonoperative closure of left-to-right shunts. *J Thorac* 

[55] Mullen, M. J.; Hildick-Smith, D.; De Giovanni, J. V.; et al. (2006). BioSTAR Evaluation

[57] Pastorek, J. S.; Allen, H. D. & Davis, J. T. (1994). Current outcomes of surgical closure of secundum atrial septal defect. *Am J Cardiol,* Vol. 74, No. 2, pp. 175-179 [58] Pavcnik, D.; Takulve, K.; Uchida, B. T.; et al. (2010). Biodisk: a new device for closure of

[59] Pavcnik, D.; Wright, K. C. & Wallace, S. (1993). Monodisk: device for percutaneous

[60] Pedra, C. A. C.; Pihkala, J.; Lee, K-J.; et al. (2000). Transcatheter closure of the atrial septal defects using the CardioSeal implant. *Heart,* Vol. 84, No. 3, pp. 320-326 [61] Perry, S. B.; Van der Velde, M. E.; Bridges, N. D.; et al. (1993). Transcatheter closure of atrial and ventricular septal defects. *Herz,* Vol. 18, No. 2, pp. 135-142

congenital heart defects. *Circulation,* Vol*.* 75, No. 3, pp. 593-599

septal defects. *Curr Intervent Cardiol Rep,* Vol. 2, No. 3, pp. 268-273

USA

279-283

4, pp. 286-291

393

1645-1650

No. 6, pp. 861-867

No. 5, pp. 308-312

*Surg,* Vol. 33, No. 1, pp. 52-59

*Cardiovasc Surg, Vol.* 72, No. 3, pp. 371-378

*Therapy in Pediatric Cardiology,* P. S. Rao (ed): 335-348, Wiley-Liss, New York, NY,

(2008). Self-expanding platinum-coated nitinol devices for transcatheter closure of atrial septal defect: prevention of nickel release. *J Invasive Cardiol,* Vol. 20, No. 6, pp.

hypothermia: experimental accomplishments and the report of one successful case.

with the buttoned device: a multi-institutional U.S. trial. *Am J Cardiol,* Vol. 73, No.

secundum atrial septal defects using the new self-centering Amplatzer septal occluder: initial human experience. *Cathet Cardiovasc Diagn,* Vol. 42, No. 4, pp. 388-

STudy (BEST): a prospective, multicenter, phase I clinical trial to evaluate the feasibility, efficacy, and safety of the BioSTAR bioabsorbable septal repair implant for the closure of atrial-level shunts. *Circulation,* Vol*.* 114, No. 18, pp. 1962-1967 [56] Murphy, J. G.; Gersh, B. J.; McGoon, M. D.; et al. (1990). Long-term outcome after

surgical repair of isolated atrial septal defect. *New Engl J Med,* Vol. 323, No. 24, pp.

patent foramen ovale: a feasibility study in swine. *Catheter Cardiovasc Interv,* Vol. 75,

transcatheter closure of cardiac septal defects. *Cardiovasc Intervent Radiol, Vol.* 16,


Historical Aspects of Transcatheter Occlusion of Atrial Septal Defects 83

[93] Sideris, E. B.; Leung, M.; Yoon, J. H.; et al. (1996). Occlusion of large atrial septal defects

[94] Sideris, E. B.; Sideris, S. E.; Fowlkes, J. P.; et al. (1990a). Transvenous atrial septal

[95] Sideris, E. B.; Sideris, E. E.; Kaneva, A.; et al. (1999b). Transcatheter occlusion of

[96] Sideris, E. B.; Sideris, S. E.; Thanopoulos, B. D.; et al. (1990b). Transvenous atrial septal

[97] Sideris, E. B.; Rey, C.; Schrader, R.; et al. (1997). Occlusion of large atrial septal defects

[98] Sideris, E.; Toumanides, S.; Alekyan, B.; et al. (2000b). Transcatheter patch correction of

[99] Sievert, H.; Babic, U. U.; Ensslen, R.; et al. (1995). Transcatheter closure of large atrial

[100] Sievert, H.; Babic, U. U.; Hausdorf, G.; et al. (1998). Transcatheter closure of atrial

[101] Stolt, V. S.; Chessa, M.; Aubry, P.; et al. (2010). Closure of ostium secundum atrial

[102] Thomsen-Bloch, A. (1995).Closure of Atrial Septal Defects with Catheter Technique:

[103] Turner, D. R. & Forbes, T. J. (2010). Cardia devices. In: *Transcatheter closure of ASDs and* 

[105] Zahn, E.; Cheatham, J.; Latson, L. & Wilson, N. (1999). Results of in vivo testing of a

[106] Zahn, E.; Wilson, N.; Cutright, W. & Latson, L. (2001). Development and testing of the

[107] Zamora, R.; Rao ,P. S.; Lloyd, T.R.; et al. (1998). Intermediate-term results of Phase I

defect occlusion system. *Circulation,* Vol. 104, No. 6, pp. 711-716

Qbandi, & H. Sievert (Eds): 407-416, Cardiotext, Minneapolis, MN, USA [104] Worms, A. M.; Rey, C.; Bourlan, F.; et al. (1996). French experience in the closure of

European trial. *Am J Cardiol*, Vol. 82, No. 11, pp. 1405-1413

356-359

1526

232-240

Denmark

No. 1, pp. 124

1, pp. 312-318

*Cardiol Young*, Vol. 9, Suppl, p. 92

[abstract]. *Circulation,* Vol. 96, No. 8S, p. I-99

*Cardiovasc Interv,* Vol. 75, No. 7, pp. 1091-1095

*Arch Mal Coeur Vaiss*, Vol. 89, No. 5, pp. 509-515

*Cardiol*, Vol. 31, No. 3, pp. 674-678

*Circulation,* Vol. 102: (Suppl) II, p. 588

with a centering device: early clinical experience. *Am Heart J,* Vol. 131, No. 2, pp.

occlusion in piglets using a "buttoned" double-disc device. *Circulation,* Vol. 81, No.

experimental atrial septal defects by wireless occluders and patches (abstract).

defect occlusion by the "buttoned" device. *Am J Cardiol,* Vol. 66, No. 20, pp. 1524-

by buttoned devices; comparison of centering and the fourth generation devices

atrial septal defects: Experimental validation and early clinical experience.

septal defects with the Babic system. *Cathet Cardiovasc Diagn*, Vol. 36: No. 3, pp.

septal defect and patent foramen ovale with ASDOS device, a multi-institutional

septum defect with the Atriasept occluder: early European experience. *Catheter*

An animal experimental study. Diploma Thesis, Aarhus University Hospital,

*PFOs: A comprehensive assessment,* Z. M. Hijazi, T. Feldman, M. H. Abdullah A Al-

atrial septal defects of the ostium secundum type with Sideris buttoned occluder.

new Nitinol ePTTEF septal occlusion device. *Cathet Cardiovasc Intervent,* Vol. 47,

HELEX septal occluder, a new expanded polytetraflouroethylene atrial septal

FDA trials of buttoned device occlusion of secundum atrial septal defects. *J Am Coll* 


[78] Rashkind, W. J. (1983). Transcatheter treatment of congenital heart disease. *Circulation,* 

[79] Rashkind, W. J. & Cuaso, C. E. (1977). Transcatheter closure of atrial septal defects in

[80] Rashkind, W. J.; Mullins, C. E.; Hellenbrand, W. E.; et al. (1987). Non-surgical closure of

[81] Rashkind, W. J.; Tait, M. A. & Gibson, R. J., Jr. (1985). Interventional cardiac catheterization in congenital heart disease. *Internat J Cardiol,* Vol. 7, No. 1, pp. 1-11 [82] Redington, A. N. & Rigby, M. L. (1994). Transcatheter closure of interatrial

[83] Rickers, C.; Hamm, C.; Stern, H.; et al. (1998). Percutaneous closure of secundum atrial

[84] Rome, J. J.; Keane, J. F.; Perry, S. B.; et al. (1990). Double-umbrella closure of atrial defects: initial clinical applications. *Circulation,* Vol. 82, No. 3, pp. 751-758 [85] Ryan, C.; Opolski, S.; Wright, J.; et al. (1998). Structural considerations in the

[86] Sharafuddin, M. J. A.; Gu, X.; Titus, J. L.; et al. (1997). Transvenous closure of secundum

[89] Sideris, E. B. (2003). Wireless devices. In: *Catheter based devices for the treatment of non-*

[90] Sideris, E. B.; Chiang, C. W.; Zhang, J. C. & Wang, W. S. (1999a). Transcatheter

[91] Sideris, B. E.; Coulson, J. D. & Sideris, E. B. (2010). Transcatheter patch device. In:

[92] Sideris, E.; Kaneva, A.; Sideris, S. & Moulopoulos, S. (2000a). Transcatheter atrial septal

84, Lippincott Williams & Wilkins, Philadelphia, PA, USA

study. *J Am Coll Cardiol,* Vol. 33 No. 2, Suppl A, p. 528

prosthesis in a swine model. *Circulation,* Vol. 95, No. 8, pp. 2162-2168 [87] Schneider, M.; Babic, U.; Thomsen, B. A.; et al., (1995). Das ASDOS-Implantat: Tierexperimentelle Erprobung. *Z Kardiologie*, Vol. 84: (Suppl.) pp. 751 [88] Schraeder, R.; Fassbender, D. & Strasser, R. H. (2003). PFO-star for closure of patent

patent ductus arteriosus: clinical applications of the Rashkind PDA occluder

communication with a modified umbrella device. *Br Heart J,* Vol. 72, No. 4, pp. 372-

septal defect with a new self centering device ("angel wings"). *Heart,* Vol. 80, No. 5,

development of the CardioSeal septal occluder. In: *Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery,* Y. Imai & K. Momma (Eds): 191-

atrial septal defects: preliminary results with a new self-expanding Nitinol

foramen ovale in patients with presumed paradoxical embolism. In: *Catheter based devices for the treatment of non-coronary cardiovascular disease in adults and children,* P. S. Rao & M. J Kern (Eds): 103-109, Lippincott Williams & Wilkins, Philadelphia, PA,

*coronary cardiovascular disease in adults and children,* P. S. Rao, & M. J Kern (Eds): 79-

correction of heart defects by detachable balloon buttoned devices: A feasibility

*Transcatheter closure of ASDs and PFOs: A comprehensive assessment,* Z. M. Hijazi, T. Feldman, M. H. Abdullah A Al-Qbandi, & H. Sievert (Eds): 373-384, Cardiotext,

defect occlusion in piglets by balloon detachable devices. *Catheter Cardiovasc* 

Vol. 67, No. 4, pp. 711-716

377

USA

Minneapolis, MN, USA

*Interventions,* Vol. 51, No. 4, pp. 529-534

pp. 517-521

children. *Eur J Cardiol,* Vol. 8, No. pp. 119-120

system. *Circulation,* Vol. 75, No. 3, pp. 583-592

193, Futura Publishing Co, Armonk, NY, USA


**Role of Transesophageal** 

Gurur Biliciler-Denktas

 *USA* 

**Echocardiography in Transcatheter** 

*University of Texas Health Science Center Houston, Division of Pediatric Cardiology* 

The incidence of atrial septal defect (ASD) is 1 in 1000 live births and account up to one third of the acyanotic shunts in the adult population. (Brickner et al. 2000; Yared et al. 2009) Patent foramen ovale (PFO) is found more than 25% of the adults. (Yared, Baggish et al. 2009) Historically, surgical closure of ASDs has been the most common therapy until new catheterbased techniques began to develop pioneered by King and Mills in 1975. (King et al. 1976; Yared et al. 2009) Currently, transcatheter closure of ASDs and PFOs is preferred to surgery in otherwise uncomplicated and favorable anatomy cases because it is technically simple and is associated with negligible morbidity and mortality. These procedures are performed for hemodynamically significant left to right shunting, to prevent stroke from recurrent paradoxical embolism and for the platypnea orthodeoxia syndrome. In addition to the above, closure of the surgically created fenestrations after Fontan operations and also baffle leaks after Mustard and Senning surgeries are all performed in the catheterization laboratory. (Hanrath 2001; Sengupta & Khandheria 2005) Several echocardiographic techniques including transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) and real time three-dimensional transesophageal echocardiography (3D TEE) are being used by many centers. (Silvestry et al. 2009) In this chapter, we will review

A good knowledge of the cardiac anatomy is needed for the echocardiographers to identify the structures and share them in a common language with the rest of the team involved in

The major septa of the heart are formed between the 27th and 37th days of development. One method by which a septum may be formed involves actively growing masses of tissue that approach each other until they fuse dividing the lumen into two separate canals (symmetrical growth). Septum may also be formed by active growth of a single tissue mass that continues to expand until it reaches the opposite side of the lumen (asymmetrical

the role of TEE in transcatheter occlusion of atrial septal defects.

the care of the patient before, during and after the procedure.

**2. Development of interatrial septum** 

**1. Introduction** 

growth). (Fig. 1)

**Occlusion of Atrial Septal Defects** 

[108] Zamora, R.; Rao, P. S. & Sideris, E. B. (2000). Buttoned device for atrial septal defect occlusion. *Current Intervent Cardiol Reports*, Vol. 2, No. 2, pp. 167-176 **6** 

## **Role of Transesophageal Echocardiography in Transcatheter Occlusion of Atrial Septal Defects**

Gurur Biliciler-Denktas

*University of Texas Health Science Center Houston, Division of Pediatric Cardiology USA* 

#### **1. Introduction**

84 Atrial Septal Defect

[108] Zamora, R.; Rao, P. S. & Sideris, E. B. (2000). Buttoned device for atrial septal defect

The incidence of atrial septal defect (ASD) is 1 in 1000 live births and account up to one third of the acyanotic shunts in the adult population. (Brickner et al. 2000; Yared et al. 2009) Patent foramen ovale (PFO) is found more than 25% of the adults. (Yared, Baggish et al. 2009) Historically, surgical closure of ASDs has been the most common therapy until new catheterbased techniques began to develop pioneered by King and Mills in 1975. (King et al. 1976; Yared et al. 2009) Currently, transcatheter closure of ASDs and PFOs is preferred to surgery in otherwise uncomplicated and favorable anatomy cases because it is technically simple and is associated with negligible morbidity and mortality. These procedures are performed for hemodynamically significant left to right shunting, to prevent stroke from recurrent paradoxical embolism and for the platypnea orthodeoxia syndrome. In addition to the above, closure of the surgically created fenestrations after Fontan operations and also baffle leaks after Mustard and Senning surgeries are all performed in the catheterization laboratory. (Hanrath 2001; Sengupta & Khandheria 2005) Several echocardiographic techniques including transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), intracardiac echocardiography (ICE) and real time three-dimensional transesophageal echocardiography (3D TEE) are being used by many centers. (Silvestry et al. 2009) In this chapter, we will review the role of TEE in transcatheter occlusion of atrial septal defects.

#### **2. Development of interatrial septum**

A good knowledge of the cardiac anatomy is needed for the echocardiographers to identify the structures and share them in a common language with the rest of the team involved in the care of the patient before, during and after the procedure.

The major septa of the heart are formed between the 27th and 37th days of development. One method by which a septum may be formed involves actively growing masses of tissue that approach each other until they fuse dividing the lumen into two separate canals (symmetrical growth). Septum may also be formed by active growth of a single tissue mass that continues to expand until it reaches the opposite side of the lumen (asymmetrical growth). (Fig. 1)

Role of Transesophageal Echocardiography

the right of septum primum and is more rigid. (Fig. 4)

red) (Courtesy of Dr. Stephen W. Carmichael)

Stephen W. Carmichael)

the population thus separating the two atria. (Fig. 5)

in Transcatheter Occlusion of Atrial Septal Defects 87

Holes in septum primum coalesce to form ostium secundum. When the lumen of the right atrium expands as a result of the incorporation of the sinus horn, a new crescent shaped fold appears. Septum secundum begins to grow over ostium secundum. Septum secundum is to

Fig. 4. Septum secundum (in green), septum primum (in blue) and ostium secundum (in

Fig. 5. Septum secundum (in green) and foramen ovale (in red arrow) (Courtesy of Dr.

Free concave edge of the septum secundum begins to overlap the ostium secundum. The tunnel like opening left by the septum secundum is the foramen ovale. Eventually within the first few years of life, the septum secundum fuses with the septum primum in most of

Fig. 1. Formation of septa. Symmetrical (middle) and asymmetrical (right) growth (Courtesy of Dr. Stephen W. Carmichael)

Atrium starts as a common chamber. At the end of the 4th week, a sickle cell shaped crest grows from the roof of the common atrium into the lumen. This is the first portion of the septum primum.

The opening between the lower rim of the septum primum and the endocardial cushions is the ostium primum. (Fig. 2)

Fig. 2. Septum primum (in pink) and ostium primum (in red) (Courtesy of Dr. Stephen W. Carmichael)

With further development, extensions of the endocardial cushions grow along the edge of the septum primum closing the ostium primum. Before closure is complete, cell death produces perforations in the upper portions of the septum. (Fig. 3)

Fig. 3. Closure of ostium primum (in blue) and perforations in the septum (in red) (Courtesy of Dr. Stephen W. Carmichael)

Fig. 1. Formation of septa. Symmetrical (middle) and asymmetrical (right) growth (Courtesy

Atrium starts as a common chamber. At the end of the 4th week, a sickle cell shaped crest grows from the roof of the common atrium into the lumen. This is the first portion of the

The opening between the lower rim of the septum primum and the endocardial cushions is

Fig. 2. Septum primum (in pink) and ostium primum (in red) (Courtesy of Dr. Stephen W.

With further development, extensions of the endocardial cushions grow along the edge of the septum primum closing the ostium primum. Before closure is complete, cell death

Fig. 3. Closure of ostium primum (in blue) and perforations in the septum (in red) (Courtesy

produces perforations in the upper portions of the septum. (Fig. 3)

of Dr. Stephen W. Carmichael)

the ostium primum. (Fig. 2)

of Dr. Stephen W. Carmichael)

septum primum.

Carmichael)

Holes in septum primum coalesce to form ostium secundum. When the lumen of the right atrium expands as a result of the incorporation of the sinus horn, a new crescent shaped fold appears. Septum secundum begins to grow over ostium secundum. Septum secundum is to the right of septum primum and is more rigid. (Fig. 4)

Fig. 4. Septum secundum (in green), septum primum (in blue) and ostium secundum (in red) (Courtesy of Dr. Stephen W. Carmichael)

Free concave edge of the septum secundum begins to overlap the ostium secundum. The tunnel like opening left by the septum secundum is the foramen ovale. Eventually within the first few years of life, the septum secundum fuses with the septum primum in most of the population thus separating the two atria. (Fig. 5)

Fig. 5. Septum secundum (in green) and foramen ovale (in red arrow) (Courtesy of Dr. Stephen W. Carmichael)

Role of Transesophageal Echocardiography

discussed further in the rest of the chapter.

**3.3 ICE** 

al. 2009; Yared et al. 2009)

**4. ASD/PFO closure devices** 

**3.4 3D TEE** 

in Transcatheter Occlusion of Atrial Septal Defects 89

requires a dedicated echocardiographer to perform the study. TEE in ASD closure will be

ICE has been introduced to cardiac imaging techniques more than 10 years ago. It has evolved from cross sectional imaging using a rotating transducer to sector based imaging using a phased-array transducer. There are three ICE catheters available with respective ultrasound systems. Most frequently used ones are 8F or 10 F ultrasound catheters. Some centers prefer ICE to other imaging modalities because of its superiority in imaging especially the inferior rim of the atrial septum, which is important in decision making to close the defect. (Kim et al. 2009) It is advantageous to TEE mostly because it avoids the need for general anesthesia. The cost of the catheter is one of the main drawbacks of using ICE. Even though closure of PFO under the guidance of ICE is safe and effective, ICE may not be sensitive enough to detect all patients with right to left shunting. (Van et al. 2010; Pedra, Fleishman et al. 2011) In addition to this, limited field view for far field device complications, the need for a second venous sheath, the requirement for additional training, potential trigger of atrial arrhythmias are among the disadvantages of ICE. In the setting of a single operator, it may be a more challenge to manipulate the ICE catheter at the same time the closure device. It is up to the center and the interventionalist to prefer ICE to other imaging techniques and there are many catheterization laboratories and interventionalists who prefer this technique during transcatheter closure of ASDs. (Kim et

After the introduction of 3D TTE during interventions, a more practical technique, 3D TEE was developed. Real time 3D TEE images have high spatial and temporal resolution that allows detailed views of the cardiac structures. (Lee et al. 2010; Tsang et al. 2011) The use of 3D TEE acquired en face views of the defect and surrounding structures allows accurate measurement of the ASD and any other additional defects like fenestrations. Since the same probe can be used for 2D TEE and 3D TEE imaging and the operator can switch in between the two modalities, this method has become one of the newer and promising techniques in

Currently there are a number of devices approved in the USA for closure of ASDs and some of these are also used off label for closure of PFOs. It is very important for the echocardiographer to be familiar with these devices, their design and release mechanisms since the method of

Atrial septal defect occlusion devices are categorized into two as non-self centered or single pin device and the waist or self-centered device. The cribriform device- AGA Amplatzer multi fenestrated septal occluder (AGA, Plymouth. Minnesota USA) (Fig. 6) and the Gore Helex septal occluder (GL Gore & Associates, Flagstaff, Arizona, USA) (Fig. 7) are among the family of single pin devices. Both the Cribriform and the Gore Helex devices are

evaluation of the atrial septum during ASD device occlusion.

implantation is different and unique for each device. (Silvestry et al. 2009)

Ostium secundum ASDs are caused either by excessive cell death and resorption of the septum primum or by inadequate development of the septum secundum.

PFO which is the result of lack of fusion between the septum primum and the septum secundum is not considered a true ASD and stays functionally closed as long as the left atrial pressure is higher than the right atrial pressure. There is a potential for right to left shunting resulting in paradoxical embolism and stroke if the right atrial pressure rises (mostly observed with valsalva) enough to open the PFO. (Johri et al. 2011)

#### **3. Echocardiographic techniques**

Echocardiography has been the widely used imaging technique that complements the fluoroscopy during closure of ASDs and PFOs. Compared to computed tomography and magnetic resonance imaging, echocardiography has the major advantage of being portable and real time. In this way, echocardiography can be performed before, during and after transcatheter interventions. (Silvestry et al. 2009) Even though fluoroscopy is the main imaging modality during interventional procedures, it does not provide direct assessment of cardiac anatomy as good as echocardiography. In addition to defining the intracardiac structures important in the ASD closure process, echocardiography is helpful in showing the relationship between catheters or devices and the adjacent structures. (Brochet & Vahanian 2010) The use of echocardiography as an adjunct to fluoroscopy has decreased the amount of total fluoro time to close an ASD.

Once the diagnosis of ASD or PFO and a decision to close it has been made, atrial septum should be assessed immediately before the procedure in the cardiac catheterization laboratory to confirm the diagnosis, during the procedure to help with device occlusion and after the procedure to reconfirm the success of the procedure without complications.

There are multiple techniques for the imaging of the atrial septum.

#### **3.1 TTE**

TTE is the simplest technique to use. It can show the device in multiple planes but does not have adequate imaging of the lower rim of the atrial septal tissue, which is above the inferior vena cava (IVC) especially after device placement. In addition to this, since the distance from the septum to the transducer is farther in TTE than TEE or ICE, the color imaging at the atrial septal level may be suboptimal. Access to the patient's body through the sterile field also poses a problem. Even though TTE may be the initial diagnostic tool, it is infrequently used in the catheterization laboratory to aid in ASD closures. (Silvestry et al. 2009)

#### **3.2 TEE**

In contrast to TTE, TEE offers better image resolution and definition of anatomy during the transcatheter closure of ASDs. It has become the standard imaging modality in many centers to monitor and guide interventional procedures because of its easy application, lower cost, portability and real time imaging. It is mostly agreed that TEE is superior to fluoroscopy in defining the defect margins and to position the device and/or its arms. (Hanrath 2001) The main limitation of TEE is the need for general anesthesia. (Brochet & Vahanian 2010) It also requires a dedicated echocardiographer to perform the study. TEE in ASD closure will be discussed further in the rest of the chapter.

#### **3.3 ICE**

88 Atrial Septal Defect

Ostium secundum ASDs are caused either by excessive cell death and resorption of the

PFO which is the result of lack of fusion between the septum primum and the septum secundum is not considered a true ASD and stays functionally closed as long as the left atrial pressure is higher than the right atrial pressure. There is a potential for right to left shunting resulting in paradoxical embolism and stroke if the right atrial pressure rises

Echocardiography has been the widely used imaging technique that complements the fluoroscopy during closure of ASDs and PFOs. Compared to computed tomography and magnetic resonance imaging, echocardiography has the major advantage of being portable and real time. In this way, echocardiography can be performed before, during and after transcatheter interventions. (Silvestry et al. 2009) Even though fluoroscopy is the main imaging modality during interventional procedures, it does not provide direct assessment of cardiac anatomy as good as echocardiography. In addition to defining the intracardiac structures important in the ASD closure process, echocardiography is helpful in showing the relationship between catheters or devices and the adjacent structures. (Brochet & Vahanian 2010) The use of echocardiography as an adjunct to fluoroscopy has decreased the amount

Once the diagnosis of ASD or PFO and a decision to close it has been made, atrial septum should be assessed immediately before the procedure in the cardiac catheterization laboratory to confirm the diagnosis, during the procedure to help with device occlusion and

TTE is the simplest technique to use. It can show the device in multiple planes but does not have adequate imaging of the lower rim of the atrial septal tissue, which is above the inferior vena cava (IVC) especially after device placement. In addition to this, since the distance from the septum to the transducer is farther in TTE than TEE or ICE, the color imaging at the atrial septal level may be suboptimal. Access to the patient's body through the sterile field also poses a problem. Even though TTE may be the initial diagnostic tool, it is infrequently used in the

In contrast to TTE, TEE offers better image resolution and definition of anatomy during the transcatheter closure of ASDs. It has become the standard imaging modality in many centers to monitor and guide interventional procedures because of its easy application, lower cost, portability and real time imaging. It is mostly agreed that TEE is superior to fluoroscopy in defining the defect margins and to position the device and/or its arms. (Hanrath 2001) The main limitation of TEE is the need for general anesthesia. (Brochet & Vahanian 2010) It also

after the procedure to reconfirm the success of the procedure without complications.

There are multiple techniques for the imaging of the atrial septum.

catheterization laboratory to aid in ASD closures. (Silvestry et al. 2009)

septum primum or by inadequate development of the septum secundum.

(mostly observed with valsalva) enough to open the PFO. (Johri et al. 2011)

**3. Echocardiographic techniques** 

of total fluoro time to close an ASD.

**3.1 TTE** 

**3.2 TEE** 

ICE has been introduced to cardiac imaging techniques more than 10 years ago. It has evolved from cross sectional imaging using a rotating transducer to sector based imaging using a phased-array transducer. There are three ICE catheters available with respective ultrasound systems. Most frequently used ones are 8F or 10 F ultrasound catheters. Some centers prefer ICE to other imaging modalities because of its superiority in imaging especially the inferior rim of the atrial septum, which is important in decision making to close the defect. (Kim et al. 2009) It is advantageous to TEE mostly because it avoids the need for general anesthesia. The cost of the catheter is one of the main drawbacks of using ICE. Even though closure of PFO under the guidance of ICE is safe and effective, ICE may not be sensitive enough to detect all patients with right to left shunting. (Van et al. 2010; Pedra, Fleishman et al. 2011) In addition to this, limited field view for far field device complications, the need for a second venous sheath, the requirement for additional training, potential trigger of atrial arrhythmias are among the disadvantages of ICE. In the setting of a single operator, it may be a more challenge to manipulate the ICE catheter at the same time the closure device. It is up to the center and the interventionalist to prefer ICE to other imaging techniques and there are many catheterization laboratories and interventionalists who prefer this technique during transcatheter closure of ASDs. (Kim et al. 2009; Yared et al. 2009)

#### **3.4 3D TEE**

After the introduction of 3D TTE during interventions, a more practical technique, 3D TEE was developed. Real time 3D TEE images have high spatial and temporal resolution that allows detailed views of the cardiac structures. (Lee et al. 2010; Tsang et al. 2011) The use of 3D TEE acquired en face views of the defect and surrounding structures allows accurate measurement of the ASD and any other additional defects like fenestrations. Since the same probe can be used for 2D TEE and 3D TEE imaging and the operator can switch in between the two modalities, this method has become one of the newer and promising techniques in evaluation of the atrial septum during ASD device occlusion.

#### **4. ASD/PFO closure devices**

Currently there are a number of devices approved in the USA for closure of ASDs and some of these are also used off label for closure of PFOs. It is very important for the echocardiographer to be familiar with these devices, their design and release mechanisms since the method of implantation is different and unique for each device. (Silvestry et al. 2009)

Atrial septal defect occlusion devices are categorized into two as non-self centered or single pin device and the waist or self-centered device. The cribriform device- AGA Amplatzer multi fenestrated septal occluder (AGA, Plymouth. Minnesota USA) (Fig. 6) and the Gore Helex septal occluder (GL Gore & Associates, Flagstaff, Arizona, USA) (Fig. 7) are among the family of single pin devices. Both the Cribriform and the Gore Helex devices are

Role of Transesophageal Echocardiography

in Transcatheter Occlusion of Atrial Septal Defects 91

Fig. 8. Multiplane views of the atrial septum. (Courtesy of Dr. Duraisamy Balaguru)

The goals of TEE are: detailed imaging of the defect and its relation to the surrounding structures, identification of patients with suitable anatomy for device closure of their ASD/PFO and guidance for the device positioning and deployment. (Brochet & Vahanian 2010) It should also be kept in mind that the rotation of the transducer to specific angles is a good initial guide but not a strict rule. The defects and other normal structures of the heart

1. Evaluation of the entire atrial septum and its surrounding structures; exclusion of

3. Color Doppler imaging of the defect and definition of the shunt (left to right, right to

4. In cases of PFO requiring further information of the shunt, injection of agitated saline micro bubbles at rest and with Valsalva to visualize any right to left shunting

6. Maximal dimensions of the length of the atrial septum and distance of the ASD from

7. Measurement of the diameter of the stretched balloon across the defect when a sizing balloon is used and identification of any residual left to right shunting (Fig. 15)

additional defects that may render the defect unsuitable for closure

**5.2 Imaging of atrial septum pre-, during and post-, device closure** 

may be imaged at closer but different angles.

5. Measurement of the defect number and size

the surrounding structures (rims) (Fig. 12)

2. Defining the defect: ASD vs. PFO

left) at rest, with Valsalva

**5.2.1 Pre-procedure** 

approved for closure of small ASDs but are widely used for PFO closure as off label indication. The self-centered devices have two atrial disks that connect with a waist. AGA Amplatzer septal occluder (AGA) (Fig. 6) and the NMT CardioSeal StarFlex septal occluder (NMT Medical, Boston, Massachusetts, USA) (Fig. 7) are the two self centered devices available for closure of ASDs in the USA.

Fig. 6. AGA Amplatzer. Multi Fenestrated Septal Occluder (left) and Septal Occluder (right)

Fig. 7. CardioSeal StarFlex Septal Occluder (left) and Gore Helex Septal Occluder (right)

#### **5. TEE in ASD device closure**

#### **5.1 TEE protocol**

Even though ASD/PFO closure evaluation asks for certain measurements, for all cases, it is very important to follow a protocol using multiplane views and available windows from gastric to mid and upper esophagus to complete a segmental approach used in evaluation of congenital heart disease. (Fig. 8) In this way, the previous findings seen by other echocardiography modalities will be confirmed and any additional defects will not be missed. (Masani 2001) Many centers already are using TEE protocols that they have developed and these can be incorporated into TEE in interventional studies.

approved for closure of small ASDs but are widely used for PFO closure as off label indication. The self-centered devices have two atrial disks that connect with a waist. AGA Amplatzer septal occluder (AGA) (Fig. 6) and the NMT CardioSeal StarFlex septal occluder (NMT Medical, Boston, Massachusetts, USA) (Fig. 7) are the two self centered devices

Fig. 6. AGA Amplatzer. Multi Fenestrated Septal Occluder (left) and Septal Occluder (right)

Fig. 7. CardioSeal StarFlex Septal Occluder (left) and Gore Helex Septal Occluder (right)

Even though ASD/PFO closure evaluation asks for certain measurements, for all cases, it is very important to follow a protocol using multiplane views and available windows from gastric to mid and upper esophagus to complete a segmental approach used in evaluation of congenital heart disease. (Fig. 8) In this way, the previous findings seen by other echocardiography modalities will be confirmed and any additional defects will not be missed. (Masani 2001) Many centers already are using TEE protocols that they have

developed and these can be incorporated into TEE in interventional studies.

available for closure of ASDs in the USA.

**5. TEE in ASD device closure** 

**5.1 TEE protocol** 

Fig. 8. Multiplane views of the atrial septum. (Courtesy of Dr. Duraisamy Balaguru)

#### **5.2 Imaging of atrial septum pre-, during and post-, device closure**

The goals of TEE are: detailed imaging of the defect and its relation to the surrounding structures, identification of patients with suitable anatomy for device closure of their ASD/PFO and guidance for the device positioning and deployment. (Brochet & Vahanian 2010) It should also be kept in mind that the rotation of the transducer to specific angles is a good initial guide but not a strict rule. The defects and other normal structures of the heart may be imaged at closer but different angles.

#### **5.2.1 Pre-procedure**


Role of Transesophageal Echocardiography

measurements

morbidity. (Momenah et al. 2000)

in Transcatheter Occlusion of Atrial Septal Defects 93

Fig. 12. Four chamber view. Septal defect size, rims (left) and total atrial septal length (right)

A PFO is defined as any anatomical communication through the foramen ovale and a stretched PFO is defined as any left to right flow on color Doppler imaging seen at rest or intermittently. Furthermore, an atrial septal aneurysm is defined as 11-15 mm of total movement of a 15 mm base of atrial tissue. (Silvestry et al. 2009) Sinus venosus, ostium primum or coronary sinus defects cannot be closed by transcatheter intervention and require surgical closure. In addition to this, associated abnormalities of the superior and inferior vena cava, coronary sinus, pulmonary veins and atrioventricular valves that may hinder the device closure should be carefully evaluated. Once the defect is diagnosed as a secundum ASD or a PFO, then the number (more than one defect at the atrial septum or fenestrations) and size of the defect needs to be identified. Currently, defects up to 40 mm in diameter and also multiple defects can be successfully closed with percutaneous transcatheter occlusion. (Silvestry et al. 2009) In addition to the size of the defect, the distance of the defect from the surrounding structures called "rims" play an important role in deciding whether a defect can be closed or not. A surrounding rim of 4-5 mm is considered to be adequate for closure except for the aortic rim which could be less. Posterior, superior (SVC) and especially the inferior (IVC) rim are to be investigated and measured from multiple TEE views for accuracy. (Fig. 14) In the cardiac catheterization laboratory, the operators should be very much familiar with the terminology when rims are mentioned. Alternatively, an easier and according to their relation to less complicated definition of the rims may be specific structures. In smaller patients, especially the pediatric population, the total septal length is also crucial since this may limit the size of the device that can be placed successfully without early or late

While interrogating the atrial septum, certain views are recommended for measurements. The diameter of the defect and the color Doppler across it should be obtained from midesophageal four chamber, from short axis at the base of the heart, from gastro esophageal junction and from bicaval view and the largest diameter should be considered while deciding on the size of the device. (Fig 12 and 13) Inferior rim of the defect to mitral valve and tricuspid valve and the total septal length can easily be visualized from mid esophageal four chamber view. (Fig. 12) The short axis view at the base of the heart gives the antero-superior rim (to aortic root), posterior rim (to pulmonary vein) and the total septal length. (Fig 13) With the gastro esophageal junction (0) or oblique (130) imaging inferior rim of the defect to the coronary sinus can be seen. Bicaval view is the choice for

Fig. 9. Secundum atrial septal defect with surrounding rims. (1. Atrioventricular valve rim; 2. Aortic rim; 3. SVC rim; 4. Posterior rim; 5. IVC rim; 6. Coronary sinus rim) (Courtesy of Dr. Duraisamy Balaguru)

Fig. 10. Atrial septal aneurysm with small left to right shunting

Fig. 11. PFO with bidirectional shunting.

Fig. 9. Secundum atrial septal defect with surrounding rims. (1. Atrioventricular valve rim; 2. Aortic rim; 3. SVC rim; 4. Posterior rim; 5. IVC rim; 6. Coronary sinus rim) (Courtesy of

Fig. 10. Atrial septal aneurysm with small left to right shunting

Fig. 11. PFO with bidirectional shunting.

Dr. Duraisamy Balaguru)

Fig. 12. Four chamber view. Septal defect size, rims (left) and total atrial septal length (right) measurements

A PFO is defined as any anatomical communication through the foramen ovale and a stretched PFO is defined as any left to right flow on color Doppler imaging seen at rest or intermittently. Furthermore, an atrial septal aneurysm is defined as 11-15 mm of total movement of a 15 mm base of atrial tissue. (Silvestry et al. 2009) Sinus venosus, ostium primum or coronary sinus defects cannot be closed by transcatheter intervention and require surgical closure. In addition to this, associated abnormalities of the superior and inferior vena cava, coronary sinus, pulmonary veins and atrioventricular valves that may hinder the device closure should be carefully evaluated. Once the defect is diagnosed as a secundum ASD or a PFO, then the number (more than one defect at the atrial septum or fenestrations) and size of the defect needs to be identified. Currently, defects up to 40 mm in diameter and also multiple defects can be successfully closed with percutaneous transcatheter occlusion. (Silvestry et al. 2009) In addition to the size of the defect, the distance of the defect from the surrounding structures called "rims" play an important role in deciding whether a defect can be closed or not. A surrounding rim of 4-5 mm is considered to be adequate for closure except for the aortic rim which could be less. Posterior, superior (SVC) and especially the inferior (IVC) rim are to be investigated and measured from multiple TEE views for accuracy. (Fig. 14) In the cardiac catheterization laboratory, the operators should be very much familiar with the terminology when rims are mentioned. Alternatively, an easier and according to their relation to less complicated definition of the rims may be specific structures. In smaller patients, especially the pediatric population, the total septal length is also crucial since this may limit the size of the device that can be placed successfully without early or late morbidity. (Momenah et al. 2000)

While interrogating the atrial septum, certain views are recommended for measurements. The diameter of the defect and the color Doppler across it should be obtained from midesophageal four chamber, from short axis at the base of the heart, from gastro esophageal junction and from bicaval view and the largest diameter should be considered while deciding on the size of the device. (Fig 12 and 13) Inferior rim of the defect to mitral valve and tricuspid valve and the total septal length can easily be visualized from mid esophageal four chamber view. (Fig. 12) The short axis view at the base of the heart gives the antero-superior rim (to aortic root), posterior rim (to pulmonary vein) and the total septal length. (Fig 13) With the gastro esophageal junction (0) or oblique (130) imaging inferior rim of the defect to the coronary sinus can be seen. Bicaval view is the choice for

Role of Transesophageal Echocardiography

ending in a wrong diagnosis. (Masani 2001)

**5.2.2 During device closure/deployment** 

the defect.

in Transcatheter Occlusion of Atrial Septal Defects 95

RA wall close to the IVC to the septum adjacent to the SVC. This structure and the valve of the IVC, Eustachian valve or Chiari network, can both be mistaken as the atrial septum thus

The echocardiographer and the interventionalist work as a team to decide on the device size to be used for ASD/PFO closure. The measurements from both the TEE and cardiac catheterization should be used in choosing the right size device. Once the device is being introduced into the heart and through the defect, the echocardiographer guides the catheterization team with the correct positioning taking into fact the adjacent structures especially AV valves and the entrapment of rims in between the discs (for AGA and Gore Helex septal occluders) and the double umbrella (for NMT CardioSeal). (Fig. 16) Once appropriate placement is confirmed with 2D and no significant left to right shunting seen by color Doppler, the device can then be deployed. (Fig. 17) Small central shunting is frequently seen through the device especially the AGA septal occluders, and this should not hinder the deployment. (Fig. 16) The slight pull of the device by the delivery system is relieved once it is deployed and the device is seen saddling in a much better fashion over

Fig. 16. AGA septal occluder. Note the device malpositioning- vertical to the atrial septum

and the ASD rather than parallel (left) and normal central shunting (right)

Fig. 17. AGA septal occluder. Correct positioning at bicaval (SVC-IVC) view (left).

Straddling the aortic rim (right)

Fig. 13. ASD and aortic rim visualized from short axis view (35º) (left); left to right color flow at ASD (right)

Fig. 14. Bicaval view showing IVC and SVC rims, ASD (left) and fenestrated ASD (right) with left to right shunting

Fig. 15. Balloon sizing of ASD. Note the measurement (in red) at the waist of the stretched balloon

visualization and measurement of the superior rim to superior vena cava and inferior rim to inferior vena cava in addition to the total septal length. (Fig. 14) The color flow entering the RA from vena cava and coronary sinus should not be misdiagnosed. (Masani 2001) Another very important structure is the crista terminalis that extends as a linear structure from the

Fig. 13. ASD and aortic rim visualized from short axis view (35º) (left); left to right color flow

Fig. 14. Bicaval view showing IVC and SVC rims, ASD (left) and fenestrated ASD (right)

Fig. 15. Balloon sizing of ASD. Note the measurement (in red) at the waist of the stretched

visualization and measurement of the superior rim to superior vena cava and inferior rim to inferior vena cava in addition to the total septal length. (Fig. 14) The color flow entering the RA from vena cava and coronary sinus should not be misdiagnosed. (Masani 2001) Another very important structure is the crista terminalis that extends as a linear structure from the

at ASD (right)

with left to right shunting

balloon

RA wall close to the IVC to the septum adjacent to the SVC. This structure and the valve of the IVC, Eustachian valve or Chiari network, can both be mistaken as the atrial septum thus ending in a wrong diagnosis. (Masani 2001)

#### **5.2.2 During device closure/deployment**

The echocardiographer and the interventionalist work as a team to decide on the device size to be used for ASD/PFO closure. The measurements from both the TEE and cardiac catheterization should be used in choosing the right size device. Once the device is being introduced into the heart and through the defect, the echocardiographer guides the catheterization team with the correct positioning taking into fact the adjacent structures especially AV valves and the entrapment of rims in between the discs (for AGA and Gore Helex septal occluders) and the double umbrella (for NMT CardioSeal). (Fig. 16) Once appropriate placement is confirmed with 2D and no significant left to right shunting seen by color Doppler, the device can then be deployed. (Fig. 17) Small central shunting is frequently seen through the device especially the AGA septal occluders, and this should not hinder the deployment. (Fig. 16) The slight pull of the device by the delivery system is relieved once it is deployed and the device is seen saddling in a much better fashion over the defect.

Fig. 16. AGA septal occluder. Note the device malpositioning- vertical to the atrial septum and the ASD rather than parallel (left) and normal central shunting (right)

Fig. 17. AGA septal occluder. Correct positioning at bicaval (SVC-IVC) view (left). Straddling the aortic rim (right)

Role of Transesophageal Echocardiography

reaches a cooler temperature. (Sengupta & Khandheria 2005)

two parts." *N Engl J Med* 342(4): 256-63.

*Heart* 96(17): 1409-17.

*Heart* 86(5): 586-92.

*Am Coll Cardiol* 53(23): 2117-28.

cardiology." *Heart* 96(18): 1485-93.

**8. Conclusion and future directions** 

complication. (Yared et al. 2009)

**7. Pitfalls** 

competitors.

**9. References** 

in Transcatheter Occlusion of Atrial Septal Defects 97

shunting is not hemodynamically significant, by many, this finding is not considered to be a

Even though TEE is one of the most widely used echocardiographic modalities, it also has pitfalls. It requires expert imaging personal to avoid any wrong diagnosis from misinterpretation of normal and abnormal anatomy of the heart, atrial septum and the defect. Even though it is superior to TTE in imaging because the probe in the esophagus is close to the heart, there may still be disturbance in image quality secondary to air within the esophagus and stomach or the air filled trachea or bronchi. In addition, during prolonged monitoring the transducer may reach its heat limit and may need to be turned off until it

During percutaneous closure of ASDs and PFOs, in addition to fluoroscopy, echocardiographic input is of utmost value to the interventionalist. Among the other imaging modalities which include TTE, ICE and 3D TEE, TEE has long been the standard imaging modality in many centers to monitor and guide interventional procedures because of its easy application, lower cost, portability and real time imaging. With the introduction of smaller transducers, it is also used in the smaller patients, especially the pediatric population. It is the preference, comfort and the expertise of the interventionalist and the echocardiographer to choose the best imaging technique for percutaneous ASD/PFO closure. Since TEE has been used for a long time with good results, it still is the choice of imaging in many of the catheterization laboratories; ICE and 3D TEE are the upcoming

Brickner, M. E., L. D. Hillis, R. A. Lange (2000). "Congenital heart disease in adults. First of

Brochet, E. and A. Vahanian (2010). "Echocardiography in the catheterisation laboratory."

Hanrath, P. (2001). "Imaging techniques: Transoesophageal Echo-Doppler in cardiology."

Johri, A. M., C. A. Rojas, A. El-Sherif et al. (2011). "Imaging of atrial septal defects:

Kim, S. S., Z. M. Hijazi, R. M. Lang et al. (2009). "The use of intracardiac echocardiography

King, T. D., S. L. Thompson, C. Steiner et al. (1976). "Secundum atrial septal defect. Nonoperative closure during cardiac catheterization." *Jama* 235(23): 2506-9. Lee, A. P., Y. Y. Lam, G. W. K. Yip et al. (2010). "Role of real time three-dimensional

and other intracardiac imaging tools to guide noncoronary cardiac interventions." *J* 

transesophageal echocardiography in guidance of interventional procedures in

echocardiography and CT correlation." *Heart* 97(17): 1441-53.

#### **5.2.3 Post device closure**

Following deployment, a detailed post procedure TEE should be performed to visualize any impingement on valves, veins and the outflow tract in addition to any residual peripheral shunting. (Fig. 18) In case of acute complications, most of the ASD/PFO occlusion devices can be retrieved in the catheterization laboratory so early post procedure identification of these findings is very important. (Johri et al. 2011)

Fig. 18. Gore Helex septal occluder after successful ASD closure (left) and AGA septal occluder with residual peripheral shunting (right)

#### **6. Complications after ASD/PFO device closure**

Potential complications after percutaneous device closure of ASDs and PFOs can be categorized into acute/early and chronic/late. In both the acute and late complications TEE plays a very important role. Initially, TEE is helpful in identifying the early complications some of which will be evident in the catheterization laboratory right after deployment.

One of the major but rare complications is device embolization which can embolize to any cardiac chamber or vessel and/or cause valvular dysfunction. Device embolization is commonly secondary to underestimation of the septal defect or the deficiency of the inferior or the superior rims. TEE may be limited in visualization if the device embolizes outside the heart especially beyond the abdominal aorta at the hepatic level or into the peripheral vasculature. (Yared et al. 2009) Once the diagnosis is made by TEE and fluoroscopy, retrieval is attempted in the catheterization laboratory. If unsuccessful, surgical retrieval is done.

Pericardial tamponade though rare is an important complication that may be seen during or acutely after device deployment. Tamponade most frequently is a result of left atrial appendage perforation during the anchoring of the trans septal guide wire though other less commonly encountered reasons may also be from right atrium, right ventricle, or right or left pulmonary vein perforation and though usually a late complication, device erosion through adjacent cardiac tissue. (Yared et al. 2009)

Transient heart block should raise the suspicion of the ASD closure device's impingement on the atrioventricular node. This finding needs to be closely followed afterwards.

Residual shunting seen immediately after device closure may decrease or disappear as the devices endothelizes within several months after deployment. As long as, the residual shunting is not hemodynamically significant, by many, this finding is not considered to be a complication. (Yared et al. 2009)

#### **7. Pitfalls**

96 Atrial Septal Defect

Following deployment, a detailed post procedure TEE should be performed to visualize any impingement on valves, veins and the outflow tract in addition to any residual peripheral shunting. (Fig. 18) In case of acute complications, most of the ASD/PFO occlusion devices can be retrieved in the catheterization laboratory so early post procedure identification of

Fig. 18. Gore Helex septal occluder after successful ASD closure (left) and AGA septal

Potential complications after percutaneous device closure of ASDs and PFOs can be categorized into acute/early and chronic/late. In both the acute and late complications TEE plays a very important role. Initially, TEE is helpful in identifying the early complications some of which will be evident in the catheterization laboratory right after deployment.

One of the major but rare complications is device embolization which can embolize to any cardiac chamber or vessel and/or cause valvular dysfunction. Device embolization is commonly secondary to underestimation of the septal defect or the deficiency of the inferior or the superior rims. TEE may be limited in visualization if the device embolizes outside the heart especially beyond the abdominal aorta at the hepatic level or into the peripheral vasculature. (Yared et al. 2009) Once the diagnosis is made by TEE and fluoroscopy, retrieval is attempted in the catheterization laboratory. If unsuccessful, surgical retrieval is

Pericardial tamponade though rare is an important complication that may be seen during or acutely after device deployment. Tamponade most frequently is a result of left atrial appendage perforation during the anchoring of the trans septal guide wire though other less commonly encountered reasons may also be from right atrium, right ventricle, or right or left pulmonary vein perforation and though usually a late complication, device erosion

Transient heart block should raise the suspicion of the ASD closure device's impingement

Residual shunting seen immediately after device closure may decrease or disappear as the devices endothelizes within several months after deployment. As long as, the residual

on the atrioventricular node. This finding needs to be closely followed afterwards.

**5.2.3 Post device closure** 

done.

these findings is very important. (Johri et al. 2011)

occluder with residual peripheral shunting (right)

through adjacent cardiac tissue. (Yared et al. 2009)

**6. Complications after ASD/PFO device closure** 

Even though TEE is one of the most widely used echocardiographic modalities, it also has pitfalls. It requires expert imaging personal to avoid any wrong diagnosis from misinterpretation of normal and abnormal anatomy of the heart, atrial septum and the defect. Even though it is superior to TTE in imaging because the probe in the esophagus is close to the heart, there may still be disturbance in image quality secondary to air within the esophagus and stomach or the air filled trachea or bronchi. In addition, during prolonged monitoring the transducer may reach its heat limit and may need to be turned off until it reaches a cooler temperature. (Sengupta & Khandheria 2005)

#### **8. Conclusion and future directions**

During percutaneous closure of ASDs and PFOs, in addition to fluoroscopy, echocardiographic input is of utmost value to the interventionalist. Among the other imaging modalities which include TTE, ICE and 3D TEE, TEE has long been the standard imaging modality in many centers to monitor and guide interventional procedures because of its easy application, lower cost, portability and real time imaging. With the introduction of smaller transducers, it is also used in the smaller patients, especially the pediatric population. It is the preference, comfort and the expertise of the interventionalist and the echocardiographer to choose the best imaging technique for percutaneous ASD/PFO closure. Since TEE has been used for a long time with good results, it still is the choice of imaging in many of the catheterization laboratories; ICE and 3D TEE are the upcoming competitors.

#### **9. References**


**7**

*USA* 

**Role of Intracardiac Echocardiography (ICE) in** 

Ismael Gonzalez, Qi-Ling Cao and Ziyad M. Hijazi\* *Rush Center for Congenital & Structural Heart Disease,* 

*Rush University Medical Center, Chicago, IL,* 

**Transcatheter Occlusion of Atrial Septal Defects** 

Nowadays transcatheter closure of atrial septal defects (ASDs) is a reality in the vast majority of countries; this procedure can be done safely and effectively in skilled hands and with the appropriate devices. Accurate and precise knowledge of the anatomy of the secundum atrial septal defect and the nearby structures is essential for the effectiveness and safe performance of ASD closure. Improvements in ultrasound technology over the last several decades have

Transesophageal echocardiography (TEE) has been the conventional imaging method for guidance in transcatheter closure of ASDs in children and adults; TEE has been shown to be safe and effective for closure of ASDs but in the majority of cases it has to be done under general anesthesia with subsequent increase in the procedure time, increased risks of

Intracardiac echocardiogram (ICE) was developed to provide accurate and precise knowledge of the anatomy of the intracardiac structures. ICE was first used in 1980s for the visualization of the coronary arteries and then it was also used as a guiding tool during radiofrequency ablation and to assist transeptal puncture techniques in difficult cases. It was our group who reported for the first time in 2001 on the use of ICE to guide device closure

Since then, multiple improvements in the ICE catheter have been developed and now it is well recognized imaging tool for guidance of several interventional cardiac and

Unlike TEE, ICE doesn't require general anesthesia, it provides accurate real time images

During the 1950s and 1960s, the first ultrasound tipped catheters were introduced because of the advancement in percutaneous procedures in the medical field, the need for close

been particularly useful for guidance during this particular invasive procedure.

anesthesia and patient discomfort after the procedure.

and the procedure can be done faster with successful results.

of ASDs and patent foramen ovale.

electrophysiological procedures.

**2. History** 

\* Corresponding Author

**1. Introduction** 

