**6.4** *In silico* **screening methods**

Biosynthetic gene clusters in a given bacteria can be identified using genome mining studies. 20 biosynthetic gene clusters are reported in a single strain of Pseudoalteromonads most of which were NPRS and PKS gene clusters [148]. CLUSEAN (CLUster SEquence ANalyzer) [149] and antiSMASH [150] are tools used for analysis of bacterial secondary metabolite biosynthetic gene clusters and can be used to predict AQS activity in a given bacterium. Using structures available in various databases, performing molecular docking [151] studies on compounds having AQS activities is possible and can provide remarkable information on molecular interactions involved in inhibition of quorum sensing.
