**8. Combination therapy**

A combination of two drugs [7] in the treatment of leishmaniasis has been tried to overcome the drug resistance, to achieve higher efficacy and cure rate, for better compliance and to reduce the overall dose, cost and side effect of each drug.

The following 3 combinations have been tested in various studies:

1.L-AMB (5 mg/kg daily as single i.v dose) + oral miltefosine daily for 7 days

2.L-AMB (5 mg/kg daily as single i.v dose) + Paromomycin (i.m) daily for 10 days

3.Oral miltefosine daily for 7 days + Paromomycin (i.m) daily for 10 days
