**10. Drugs used in topical therapy**

1.Paromomycin 15% and MBCL (methyl benzethonium chloride)12% ointment

It is applied topically twice a day for 10 days and the cycle is repeated after 10 days of the waiting period. Methlybenzethonium itself has some antileishmanial activity and it helps in the penetration of paromomycin. Topical preparation may cause local inflammation [13].

2.Paromomycin 15% and gentamicin 0.5% cream

Applied topically once a day for 20 days [14].
