**6. Amphotericin B (AMB)**

Amphotericin B [5] is the first-line drug for visceral leishmaniasis and the second choice of drug for mucocutaneous leishmaniasis. Can be used in leishmaniasis associated with HIV disease, pregnancy and breastfeeding patients.

#### **6.1 Dose and formulations**

This drug is available in two forms- a less expensive formulation with deoxycholate (AMB-DOC) and a highly expensive form incorporated with liposomes (L-AMB). Since the toxicity is less with L-AMB it is most commonly used for treatment and research purposes.
