**2.19 Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase, EC 3.6.1.23)**

The levels of dUTP are kept low by the action of dUTPase, a ubiquitous enzyme that catalyzes the hydrolysis of dUTP to PPi and dUMP, a substrate for thymidylate synthase (TS) [204]. The purification and characterization of *L. major* dUTPase were reported alongside its crystal structure [205, 206].

Deoxyuridine derivatives were shown to inhibit *L. major*, and human dUTPase enzymes exhibited moderate activity against *L. donovani* [207].
