**6. Conclusion**

CL has a global prevalence and there is an increase worldwide in recorded cases, and also considers from neglectful diseases. The dermal lesion is occurred by an obligate intracellular *Leishmania* parasite, which transmits via the bite of the female sandfly. The clinical appearances depend on *Leishmania* species, virulence factors and host immunologic response. Virulence factors have an important role in pathogenicity, so inhibition or absence one of them lead to effecting on parasite.
