**5.2 Adverse events**

Diarrhoea, anorexia, nausea, vomiting, reproductive toxicity in animals. These are common reactions during the first week of treatment so the drug should be taken in divided doses with meals to diminish nausea, vomiting, diarrhoea. Miltefosine is known to cause reversible nephrotoxicity and hepatotoxicity, hence monitoring (once a week) of renal and liver function tests is recommended during the treatment period.

#### **5.3 Contraindications**

Pregnancy (teratogenic) and lactation. The female patient should avoid pregnancy during and till 3 months after stopping treatment.
