**2.18 Uridinediphosphate-glucose pyrophosphorylase (UGPase, EC 2.7.7.9)**

UGPase enzyme catalyzes the reaction of UTP and glucose-1-phosphate to 3-UDP-glucose and PPi in the presence of Mg2 *in vivo*. It was reported that protozoan UGP differed from its mammalian counterparts which might provide selectivity [202]. *L. major* UGPase three-dimensional structure was reported but there has not been any reported *in vitro/in vivo* inhibitor of the enzyme yet although virtual screening campaigns have been applied to the enzyme [203].
