**3.1 Pro-convulsant effect of angiotensin II**

Some reports suggested that ACE2 could also be part of a specific mechanism for seizure induction by SARS-CoV-2, with upregulation of components of the renin-angiotensin-aldosterone in the hippocampus of patients with temporal lobe epilepsy. Downregulation of ACE2 would lead to higher concentration of angiotensin II with angiotensin II receptor type 1 (AT1) activation, which is known to cause vasoconstriction and promote inflammatory cascade. ACE2 also plays a role in kallikrein-kinin system, important for maintenance of cardiovascular system homeostasis. These findings point to a pro-convulsant effect of angiotensin II, theoretically increasing susceptibility to seizure occurrence in COVID-19. However, no experimental or clinical data have yet supported this hypothesis yet [26].
