**3. SARS-CoV-2 infection and acute symptomatic seizures**

Seizure is a relatively uncommon neurological complication of SARS-CoV-2 infection, accounting for less than 1% of patients [17, 24, 25], despite a significant proportion of patients presenting risk factors such as hypoxia, acute cerebrovascular disease, and metabolic derangements [26]. Prevalence was lower compared with previous MERS-CoV and SARS-CoV (8,6% and 2,7%, respectively) [24, 27].

Acute symptomatic seizures can occur in infection setting particularly in patients with poor general condition and fever [25], but a few case reports stated it as a presenting symptom of SARS-CoV-2 infection without the classical respiratory symptoms [27–29]. No study has yet clarified any direct relation between COVID-19 and the potentiation of epileptic seizures. At least in some patients with a history of epilepsy, they could merely reflect unprovoked seizures [26].

Nonetheless, several mechanisms were proposed for seizure generation and epileptogenesis in SARS-CoV-2 infection setting.
