**3.4 Electroporation**

Electroporation uses very short pulses of high voltage (10–100 V) to perforate the skin. Like microneedles and iontophoresis, this is also a non-invasive method of drug delivery since this method breaches only the stratum corneum [117]. Application of electric current disrupts the structure of the lipid-bilayer. This disruption allows the protein or peptide of interest to penetrate the skin. One advantage of this method is that the delivery of drugs can be easily changed by changing the voltage, number and duration of pulses, etc. [112].
