*2.2.3 Polymer hydrophobicity*

The hydrophobicity of aliphatic polyesters is key to their hydrolytic degradation. When aliphatic polyesters are more hydrophobic, they are less water-sensitive and less susceptible to ester linkage hydrolysis than more hydrophilic polyesters. This causes a decrease in nanoparticle swelling, which results from the low water uptake. These polymers have high hydrolytic resistance and a slower degradation rate. Additionally, a large number of entanglements causes a slower release rate.
