**3.6 Biochemical enhancers**

Biochemical enhancement utilizes biomolecules to enhance the permeability of the skin towards the peptide or protein of interest. This method aims to allow the entry of the drug molecule into circulation while being non-toxic, non-irritating, and nonallergenic [118]. Magainin, a 23-amino acid-containing peptide, has been reported to form pores in the bacterial cell membrane [119, 120]. Another small peptide TD1 increases the transdermal penetration capability of hEGF when fused together [121]. This system may play a vital role in delivering hydrophilic peptides transdermally.
