**8.4 Lysolipid thermally sensitive liposomal (LTSL) technology**

Thermally sensitive liposomes release drug from sites which have elevated temperature in our body. Phospholipids like DPPC and MSPC are generally used for preparing these types of liposomes. They are called temperature dependent liposomes. Lipid components present in these thermosensitive liposomes first forms gel to liquid during higher temperature which will be more permeable for drug release. ThermoDox® liposomal formulation prepared with LTSL technology by Celsion Corporation contains doxorubicin drug and present in clinical phase III trials. ThermoDox® has more drug concentration compared to intravenous doxorubicin and present in clinical studies (phase II) used in breast cancer associated to chest wall [71].
