**11.3 PD-L1 inhibitors**

The monoclonal antibodies atezolizumab and avelumab target the PD-L1, a transmembrane protein found on tumor cells. Avelumab is a fully human IgG1 MAB that binds to PD-L1, while as Atezolizumab is a humanized IgG1 isotype


**Table 3.**

*Main monotherapy clinical trials of immune checkpoint inhibitors in mTNBC.*

monoclonal antibody that binds to PD-L1. The FDA has approved these PD-L1 inhibitors for the treatment of other solid tumors, and they are currently being explored further for the treatment of TNBC.
