**5. Pathway or network mapping**

These approaches have been widely used to identify drugs or drug targets for repurposing strategy [62]. This approach gives information about upstream or downstream genes of the GWAS-associated target, which can be thought of having repurposing potential [63]. This involves constructing drug or disease networks based on gene expression patterns, disease pathology, protein interactions, or GWAS or signature matching data to identify the repurposing candidates [64]. This approach helped in identification of 67 common biological pathways having common role in respiratory viral infections [62]. When analyzed against the DrugBank database, these pathways were found with a potential effect against host-viral targets. Pranlukast, a leukotriene receptor 1 antagonist, is one such drug used in asthma and Amrinone, a phosphodiesterase inhibitor, used in the treatment of congestive heart failure that has also been found for repurposing strategy.
