**3.7 Colon and lung cancer**

The WNT/TCF signaling pathway is constitutively active in many tumors and it regulates genes for cell growth and proliferation. Ivermectin can inhibit the WNT-TCF signaling pathway by decreasing cyclin D1, which is a direct target in this pathway and ivermectin also affects the phosphorylation of β-catenin, which leads to inhibition of proliferation and increased apoptosis in lung and colon tumor cells at concentrations above 5 μM [13].
