*6.5.2.2 Primary screening by blind docking method*

Despite primary screening done by the blind docking method, several studies have been conducted to introduce effective 3CLpro inhibitors. However, to date, binding pockets and key amino acids in the enzyme catalytic activity are not well known. Therefore, as primary screening, the blind docking processes through Molegro Virtual Docker 6.0 software were performed between the standard drugs and the 3CLpro to determine the key amino acid(s). In blind molecular docking, the whole surface of a subjected receptor is considered for evaluation of probable interactions with the ligand.
