**6.5 Lamellarin D**

This alkaloid represents an excellent cytotoxic effects towards tumor cells and proposed to be an anticancer agent for targeted topoisomerase –I cancer therapy [50]. This series of alkaloids represents an ideal source for developing anti-cancer agents. A few aspects of the various mechanism imposed by the lamellarin analogue, made this peptide to be used in biotechnology and pharmaceutical industries [51] (Marco et al.,).

Schupp and his co-workers reported alkaloids of Staurosporine and their eight subderivative alkaloids analogues such as 3-hydroxystaurosporine, 4-N-demethylstaurosporine, 3-demethoxy-3-hydroxylstaurosporine, 3-hydroxy-3-demethoxy-3-hydroxystaurosporine, 11-hydroy-4-N-demethylstaurosporine, 11-hydroxystaurosporine, 4-N-methylstaurosporine, 3-hydroxystaurosporine. These alkaloids were isolated from *Eudistoma toealensis*, a colonial ascidian and its alkaloids are being used in biotechnology and pharmaceutical industries.

### **6.6 Somocystinamide A**

A lipopeptide isolated from *Lyngbya majuscula* (**Figure 6**), showed potent cytotoxic activity against N2A cells. It was found to be an potent apoptosis inducer

#### **Figure 6.** *Image showing ascidian* Lyngbya majuscula*.*

towards a number of cell lines, activation of caspase 8 and angiogenic endothelial cells via intrinsic and extrinsic pathways.
