*2.3.6 Caerulein precursor fragment (CPF)*

CPF-AM1 is a cationic AMP firstly isolated from *X. amieti* [110]. This peptide is capable of bacterial binding LPS and has activity against Gram-negative and Grampositive bacteria, primarily oral and respiratory pathogens, with advantages such as low hemolytic activity and lack of toxicity against fibroblast cells [109]. This anti-*A. baumannii* peptide inhibits the growth of sensitive and colistin-resistant strains at 16–128 and 4–128 μg/ml, respectively [104, 114]. CPF-B1, isolated from Marsabit clawed frog *Xenopus borealis*, is another anti-*A. baumannii* member of this family with low hemolytic activity. This peptide inhibits MDR *A. baumannii* clinical isolates at concentrations of 11.4–22.8 μg/ml [112]. Finally, CPF-C1 is a peptide member of this family with proved anti-*A. baumannii* effect with inhibitory activity against the strain at 5 μg/ml concentration [111].
