**5. Polyketides from ascidian associated microbes**

### **5.1 Patellazoles**

Patellazoles A-C (**Figure 3**) are a family of compounds produced by the alphaproteobacterium *Candidatus Endolissoclinum faulkneri*, a microbe found in association with the ascidian *Lissoclinum Patella*. It shows cytotoxicity towards HCT 116 cells by inhibiting protein synthesis. It has several functional roles such as arresting of cell cycle at G1/S phases, and induces cell apoptosis [38].
