*2.1.4 Wallaby antimicrobial*

The marsupial AMP Wallaby antimicrobial 1 (WAM-1) is a cathelicidin isolated from the mammary gland of the Tammar wallaby (*Macropus eugenii*) with antibacterial and antifungal activities with high potential to combat drug-resistant pathogens [84, 157]. Spencer et al. (2018) studied the AMP LL-37 and WARM-1 effects on MDR *A. baumannii*, and both peptides were able to inhibit biofilm formation in all clinical isolates at some concentrations of WAM-1 effectively dispersed 24-h biofilms in most isolates tested, including MDR strains [85]. The antibacterial effects of LL-37are diminished in the presence of human serum. However, this is not the case with WAM-1. Although the mechanism of action has yet to be determined, WAM-1 has been shown *in vitro* to be 12 to 80 times more effective than LL-37 in its ability to kill several bacterial pathogens, including several clinical isolates of *A. baumannii*. Unlike LL-37, WAM-1 is not inhibited by high NaCl concentrations and does not cause hemolysis in human red blood cells (RBC), so it has the potential to be used for *in vivo* applications [85].
