**4. Discussion**

This cohort study is based on the effectiveness of transabdominal ultrasound on the detection of GBP.

GBP is the frequent vesicular lesions, which are found frequently on abdominal ultrasonography [8]. Asymptomatic GBP is present in 5% of adults [9].

The abdominal ultrasonography presents the first line radiological means for the diagnosis of gallbladder diseases and the perfect examination for diagnosing polyps [4, 8]. Considering that it has the lower cost-effectiveness, convenient accessibility, the lack of radiation, and because of its higher sensitivity 93% and specificity 95.3% [8–10].

On the ultrasound, GBP appears as an elevated, immobile lesion of the wall, it has a posterior acoustic shadow, and it appears as a sessile lesion [11, 12].

Despite the routine use of ultrasound, it seems that its positive predictive value in diagnosing polyps is still low [13].

It can present some limitations because it is operator-dependent [14], and it can provide errors in the determination of polyps, their numbers, and their size [8].

As an example, a gallstone can be easily mistaken for a polyp on ultrasonography [15], as it can be only identified on ultrasound if it measures over 5 mm [15].

Many hypotheses have been studied to explain the poor sensitivity of ultrasound in determining true polyps, Kratzer proposed in this case, that the initial diagnosis of a polyp might be incorrect [7]. As seen in the Cochrane review that the cause of false diagnoses by ultrasound was generally a result of misinterpretation of gallstones as polyps [10].

However, Ostapenko [13] has concluded that seven patients of 34 with GBP did not have a detectable polyp, supporting the argument that the initial diagnosis was a false positive.

In our series, ultrasound had a sensitivity of 36.4%. Several factors could explain this result. Since ultrasound is a dependent operator examination, gall bladder stones, especially those of small size, could be taken on account of a polyp. The polyp's migration to the bile ducts could be another explanation and would probably be the cause of the hepatic colic. The absence of polyp on the histological examination could also be explained by the manipulation of the gallbladder during cholecystectomy.

In case of diagnostic difficulties, and mainly when malignancy is suspected, other complementary investigations can be more helpful [14, 16, 17] presenting by:

Contrast-enhanced sonography: which is an ultrasound enhanced by the injection of a medium non-irradiating ultrasonic contrast (microbubbles), is more specific in the study of vascularity, showing hyper-echoic contrast during the arterial phase and iso-echoic images during the venous phase. So, it is more

*Ultrasound Modality in the Evaluation and Management of Gallbladder Polyps DOI: http://dx.doi.org/10.5772/intechopen.101337*

useful to identify gallbladder polyps of multiple stones and from other polypoid lesions [9, 14].

Magnetic resonance imaging (MRI): It is a particular modality used in the differentiation between gallbladder polyps from other polypoid lesions, especially adenomyomatosis [14].

Positron emission tomography (PET): It is used to evaluate the malignancy diagnosis in polyps rising more than 10 mm by hypermetabolism [14].

Endoscopic ultrasound (EUS): It is determined to be better than ultrasound, it is the best modality in diagnosing gallbladder polyps [15], especially when there is suspicion of regional lymph nodes, providing the staging of polypoid lesions [14, 15].

Conventional ultrasound is sufficient to investigate GBP compared to other modalities, however, it has been proven in some studies that endoscopic ultrasound is more specific and exact, especially in the differentiation between true and pseudopolyps [11].

Guo [8] confirmed the accuracy of ultrasound for polyps diagnosis which was 78.8% in their work, and its accuracy for differentiation between benign and malignant polyps, which was confirmed in the Cochrane review [10]. Our results are in line with these cohort studies.

On ultrasonography, the polyp echogenicity is used to distinguish between true, pseudopolyps, and gallstones [18].

Its main role is to identify prematurely the progression of polyps to malignant carcinomas [13]. Polyps size is considered the main indicator of potential malignancy [16].

According to the guidelines, an arbitrary cut-off of 10 mm is confirmed to indicate cholecystectomy, which is justified by the increased incidence of gallbladder carcinoma in the polyps rising sharply from 10 mm and upwards [11, 16, 18, 19].

Polyps can cause symptoms and the relationship between symptoms and risk of malignancy is still controversial according to the literature, so cholecystectomy is wisely indicated when GBP are symptomatic [11].

Many factors that influence the therapeutic strategy of GBP were studied, including mainly the polyp size on radiological findings [18].

Referring to the literature (recent guidelines by the ESGAR group), the main factors that determine malignancy included primarily—the size greater than 10 mm, the sessile morphology, the presence of symptoms, the age 50 years and older, the Indian ethnicity, and the associated primary sclerosing cholangitis (**Figure 2**) [14, 18, 20].

Several retrospective studies showed controversial results about factors influencing malignancy and indicating cholecystectomy, which are—concomitant gallstones, elevated CA 19-9 marker, rapid polyp growth, and the number of polyps [14, 18, 20].

Gallbladder polyps are generally diagnosed and monitored by ultrasonography which is debated in the literature, discussing its accuracy [16]. Some studies confirmed its failure for the diagnosis, seen the absence of polyps at numerous histological examinations [16].

Several series have studied the correlation between ultrasound findings and histopathology results, concluded significant conjunction for the size determination between both modalities [15].

Elmasry [16] showed a significant number of gallbladder polyps that were not seen at histological examination postcholecystectomy, with an incidence of 16.4% of all histological results. This can be explained that polyps may be destroyed by the mechanical action of the gallbladder wall [7].

### **Figure 2.**

*Management algorithm for gallbladder polyps [11].*

Nonresected GBP which are smaller than 10 mm are recommended to be followed up regularly with serial ultrasound imagery [15], every 6 months–1 year for those under 5 mm, every 3–6 months for those with a dimension of 5–10 mm [1].

Follow-up strategy of GBP is not yet based on any consensus on the size of polyps, neither on its frequency or duration. Recently, the guidelines of ESGAR states recommend that polyps of 6–9 mm should be supervised prudently than polyps of less than 6 mm [18]. So that the measurement of polyps size is mandatory during the follow up of GBP—it was found that 6.9% of polyps increased their size during the monitoring period [12].

It has been proven that there was no evidence data published to define the increasing size of the polyps during surveillance, which may be an indicator for cholecystectomy [2].

### **5. Conclusion**

Preoperative diagnosis of GBP distinguishing malignant from benign lesions is challenging. Literature has highlighted the accuracy of ultrasound as the key modality for GBP detection.

It is used to be the gold standard, seeing it has relatively low-cost, low-risk, and widely available techniques. However, many studies discussed its ineffectiveness in polyp diagnosis, despite its major role in European guidelines. Leading to the essential role of other modalities such as magnetic resonance imaging, and endoscopic

*Ultrasound Modality in the Evaluation and Management of Gallbladder Polyps DOI: http://dx.doi.org/10.5772/intechopen.101337*

ultrasound. In the upcoming, studies should investigate more on the utility of these newer imaging techniques to enhance a new multimodal strategy to gallbladder polyp investigation.
