**4.3 Different pathways**

Developing new technologies have widened our understanding of chordoma by implicating innovative pathways to understand the pathogenesis and future therapeutic approach. Alteration in cell-cycle regulation and different signaling pathways have been identified in chordomas. It is also well established that different growth factor signaling is also related to pathogenic mechanisms in chordoma. There are a number of pathways and cyto-molecular factors which are associated with the pathogenesis of chordoma and some are listed in **Table 1**.
