**4.4 Epigenetics**

Critically, myxoid chondrosarcoma harbors repetitive genetic rearrangements including the NR4A3 gene, demonstrating an exceptionally useful confirmatory diagnostic indication. Other proteins namely EWSR1 and TAF15 are also involved in this type of cancer. Some researchers also described uncommon combination of transcripts like HSPA8-NR4A3, TFG-NR4A3, and TCF12-NR4A3 which can play a major role in the initiation and development of this malignancy [15]. Currently, no predictive factor is accessible to assist decision making for this metastatic process, and in specific to characterize whether systemic treatment ought to be utilized.
