Meet the editors

Dr. Anish Khan is an assistant professor at the Center of Excellence for Advanced Materials Research (CEAMR), Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. He obtained a Ph.D. from Aligarh Muslim University, India, in 2010, and a postdoctoral degree in Electroanalytical Chemistry from the School of Chemical Sciences, University Sains Malaysia (USM), in 2010. Dr. Khan works in the fields of sensors, poly-

mer composites, and organic-inorganic electrically conducting nanocomposites. He has more than 250 research articles, 80 book chapters, 50 edited books, and more than 20 international conferences/workshops to his credit. He is an editorial board member for several international journals.

Prof. Mohammed Muzibur Rahman received his BSc and MSc from Shahjalal University of Science & Technology, Sylhet, Bangladesh, in 1999 and 2001, respectively. He received his Ph.D. from Chonbuk National University, South Korea, in 2007. He worked as a postdoctoral fellow and assistant professor in pioneering research centers and universities located in South Korea, Japan, and Saudi Arabia. Presently, he is an associate professor at

the Center of Excellence for Advanced Materials Research (CEAMR) and Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He has published more than 245 international and domestic conferences and several book chapters. He has also edited ten books. His research interests include photocatalysis, semiconductors, nanoparticles, carbon nanotubes, nanotechnology, electrocatalysis, sensors, ionic liquids, surface chemistry, electrochemistry, and nanomaterials.

Dr. M. Ramesh received an ME in Computer-Aided Design (CAD) from the University of Madras, Tamil Nadu, India, and a BE in Mechanical Engineering from Bharathiar University, Tamil Nadu, India. He obtained a Ph.D. in Mechanical Engineering in the field of ecofriendly composite materials from Jawaharlal Nehru Technological University (JNTU), Andhra Pradesh, India. He has published thirty-four research papers in SCI and

Scopus-indexed journals, ten book chapters, and presented several papers at both national and international conferences. He has presented his research papers at universities throughout India, including IIT Guwahati, IIT Madras, University of Petroleum and Energy Studies Dehradun, Nirma University Ahamadabad, NIT Suratkal, VIT University, and others.

Prof. Salman Ahmad Khan received his master's degree in Organic Chemistry from Dr. Rammanohar Lohia Avadh University, Uttar Pradesh, India. He obtained a Ph.D. from Jamia Millia Islamia, New Delhi, India, in 2007. In the same year, he joined the Department of Chemistry, Punjabi University as a research associate. In 2008, he was an assistant professor in the Department of Chemistry, Integral University, Lucknow-UP. Dr. Khan

joined the Department of Chemistry, King Abdulaziz University, Jeddah, Saudi

Arabia, in 2009 as an assistant professor and was promoted to associate professor in 2014. Recently, he joined the School of Sciences, Maulana Azad National Urdu University (MANUU) as a professor. His current research interests include heterocyclic chemistry, chromones, chalcones, Anthraquinones, cholesterol, stigmasterol, photophysical, physicochemical, and multi-step reactions, one-pot multicomponent synthesis, sensors, and nanotechnology. Dr. Salman has supervised master's and Ph.D. theses. He is also an active researcher and has published more than 150 research articles in international journals.

Prof. Abdullah Mohammed Ahmed Asiri is a professor and chairman of the Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia. He is also the director of the university's Center of Excellence for Advanced Materials Research (CEAMR). He obtained a Ph.D. in tribochromic compounds and their applications from the University of Wales College, Cardiff, UK, in 1995. He is the director of the Education Affair Unit–

Contents

**Section 1**

Acetic Acid

**Section 2**

*by George Ngusale*

*by El Houssine Mabrouk*

Reversible Reactive Hotmelt Adhesives

Wood Adhesives and Bioadhesives *by Antonio Pizzi and Anish Khan*

**Preface III**

Furans and Furan Derivatives - Recent Advances **1**

**Chapter 1 3**

**Chapter 2 23**

**Chapter 3 33**

Furans and Furan Derivatives - Applications **43**

**Chapter 4 45**

**Chapter 5 65**

**Chapter 6 75**

Catalytic Enantioselective Reactions of Biomass-Derived Furans

Synthesis and Characterization of New Racemic α-Heterocyclic

2-Benzamido-2-[(Tetrahydro-Furan-2-Ylmethyl)Amino]Acetate and 2-Benzamido-2-[(Tetrahydro-Furan-2-Ylmethyl)Amino]

Furan Functionalized Polyesters and Polyurethanes for Thermally

*by Laxmisha M. Sridhar, Andrew T. Slark and James A. Wilson*

Pyrolysis of Furfural Residues and Possible Utilization Pathway

Furanic Rigid Foams, Furanic-Based Bioplastics and Furanic-Derived

Density Functional Theory and Molecular Modeling of the Compound 2-[2-(4-Methylphenylamino)-4-phenylthiazol-5-yl]benzofuran

*by Dong Guk Nam, Jung Woon Yang and Do Hyun Ryu*

*by Yardily Amose, Fathima Shahana and Abbs Fen Reji*

α,α-Diaminoester and α,α-Diamino Acid Carboxylic:

Deanship of Community Services. Dr. Asiri is a member of the advisory committee for advancing materials, National Technology Plan, King Abdul Aziz City of Science and Technology, Riyadh, Saudi Arabia. He is an editorial board member of the J*ournal of Saudi Chemical Society, Journal of King Abdul Aziz University, Pigment and Resin Technology Journal, Organic Chemistry Insights, Libertas Academica, and Recent Patents on Materials Science*. Dr. Asiri holds membership in several national and international societies and professional bodies.

## Contents


**Chapter 7 95** Furfural: A Versatile Derivative of Furan for the Synthesis of Various Useful Chemicals *by Kazeem Adelani Alabi, Rasheed Adewale Adigun, Ibrahim Olasegun Abdulsalami and Mariam Dasola Adeoye*

Preface

The modern world is moving towards sustainable development and furan is a key material in this transition. Furan is processed from furfural, which is an organic compound obtained from biomass feedstock. Thus, furan is a green and environmentally friendly material. It is used to produce pharmaceuticals, resin, agrochemicals, and lacquers. It is an important starting material for a variety of industries for the preparation of many useful products. This book presents

Chapter 1 presents recent developments in catalytic enantioselective reactions of furans derived from biomass, such as unsubstituted furan, 2-methylfuran, 2,5-dimethylfuran, and furfural. Although several review articles have dealt with the Diels-Alder reactions of furans, there have been no articles highlighting enantioselective versions. The resulting products derived from the catalytic enantioselective reaction of furan are often found as core structures in natural products and pharmaceuticals with important pharmacological activities. After recognizing the valuable skeleton of chiral furan derivatives, numerous attempts have been made to synthesize them by utilizing enantioselective cycloaddition reactions, Friedel-Craft reactions, and nucleophilic addition reactions. Enantioselective cyclization reactions using furans as the 4π diene component provided chiral dihydrofuran derivatives. On the other hand, Friedel-Craft and nucleophilic addition reactions served various

Chapter 2 examines the synthesis of the compound 2-[2-(4-methylphenylamino)-

4-phenylthiazol-5-yl]benzofuran prepared from 1-(4-methylphenyl)-3- (N-phenylbenzimidoyl)thiourea and 2-(2-bromoacetyl)benzofuran in the presence of triethylamine and characterized by FTIR, NMR, and mass spectra. Density functional theory (DFT) computations were adopted for the geometric optimization of this compound to evaluate the Mulliken atomic charge distribution, HOMO-LUMO energy gap, and vibrational analysis. The titled compound induced G1 cell cycle arrest, which is regulated by CDK2 in cancer cells. Therefore, we used molecular modelling to study in silico the possible inhibitory effect as a mechanism of this compound as anticancer agents (PDB code:2KW6, 6DL7, 6VJO, 6WMW, 7LAE). The molecular docking study revealed that the compound was

Chapter 3 reports on the synthesis of new α,α-diaminoester and α,α-diamino acid derivatives, as 2-benzamido-2-[(tetrahydro-furan-2-ylmethyl)amino] acetic acid through alkaline hydrolysis reaction of corresponding N-benzoylated methyl α,α-diamino ester. The α,α-diaminoester derivative was synthesized by nucleophilic substitution of methyl α-azido glycinate N-benzoylated with 2-tetrahydrofuran-2-ylmethan-amine. The structure of these products was

Chapter 4 describes new reactive hotmelt (RHM) adhesives based on thermally reversible Diels-Alder networks comprising multifunctional furan and maleimide prepolymers. The prepolymer mixture is easy to apply in bulk from the melt

H, 13C) and MS data.

comprehensive information on furan and its derivatives.

furan derivatives with the chiral carbon atom in the a-position.

most effective in inhibiting CDk2 cancer cells.

established on the basis of NMR spectroscopy (1
