**5. Conclusion**

The results of various clinical trials that examined ICIs and angiogenesis inhibitors have been published in recent years. These trials have demonstrated better treatment options for MPM, but personalized medicine remains in the distant future. Although, MPM is a rare disease, the prognosis remains extremely poor. Therefore, it is necessary to conduct more clinical trials and translational investigations to establish personalized treatment options that can provide the most benefit to individual patients.
