**15. RES has evolved to be a viable agent for the treatment of PD**

RES has been shown to execute biological action that alleviates deregulated inflammation, and restores both soft and bony tissues, *in vitro*, and *in vivo*, via modulation on the genetic, protein, and cellular level, thus strengthening the case for RES as a therapeutic for PD. Further to this, improvement of the pharmacokinetic and physicochemical limitations of RES has been demonstrated via nanoformulation. There is now much work to be done in identifying and optimising the ideal nanoformulation and administration route to achieve optimal benefit from the activities RES has demonstrated.
