**2.2 Selection of protein targets in** *S. mutans*

The first inclusion criterion was the selection of S. mutans target proteins with high relevance for the virulence of this microorganism [28]. The availability of the crystallographic structures resolved and available in the Protein Data Bank (PDB) was the second inclusion criterion. The protein targets (receptors), their functions, PDB identifiers, and grid box coordinates are presented in **Table 1**.
