**5.6 Diabetes mellitus**

The relationship between PD and diabetes mellitus (DM) has also been studied with respect to *Pg.* For example, gingipains carried by OMVs derived from oral *Pg*, decreased the insulin sensitivity of hepatocytes whilst hepatocytes invaded by *Pg* were also found to display a decrease in glycogen synthesis *in vitro* (human) and *in vivo* (mouse model) [70].
