**7. Other syndromes**

RME proved to be a beneficial treatment in a patient with Turner syndrome. Followed by an esthetic rehabilitation of dental morphology proved feasible to achieve facial and smile harmony [50].

Also, in patients affected by imperfect osteogenesis and treated with bisphosphonates, RME could be performed with a standardized protocol without complications after a follow-up of one year [51].

In the case of a child with Schwartz-Jampel syndrome, severe OSA, constricted maxilla, and moderate tonsillar hypertrophy, who could not tolerate the initially prescribed CPAP, following RME therapy, as the pressure setting decreased, the patient showed better compliance with CPAP [52].

Rapid blood cell turnover and bone marrow expansion produced by beta-thalassemia (βT) lead to dentoalveolar and craniofacial abnormalities. The recent literature proposes early interceptive orthodontics to reduce dentoskeletal anomalies, severe malocclusion, and soft tissue imbalance. Therapy includes dental-maxillomandibular orthopedic and functional management with dental-maxillary treatment, preventing orthosurgical procedures later or minimizing their extent. So, an interdisciplinary approach involving a pediatrician, a hematologist, an orthodontist, and a pediatric dentist may enhance the patient's quality of life [53].

Also, ETA proved beneficial in causing significant improvement in patients having combined cleft lip and palate [54]. These children's conductive hearing loss and middle ear effusion improved significantly during RME and after six months of follow-up [55]. Also, a study showed that the correction of the palatal anatomy through RME had a positive and statistically significant effect on improving hearing and middle ear function in patients without cleft and with bilateral cleft lip and palate, with normal hearing levels and with mild conductive hearing loss. Likewise, RME significantly influenced voice quality in patients without cleft but had no significant effect in patients with bilateral cleft lip and palate [56].
