**11. Conclusion**

Peri-implantitis is an inflammatory disease of microbial origin causing bone loss around the implant, which could lead to the loss of the implant. The etiology of peri-implantitis is associated with a complex microbial biofilm and risk factors such as smoking and diabetes. Occlusal overloading, osteoporosis, and other factors compromising the surgical site might adversely affect the severity of the destruction of the peri-implant tissue. Several surgical and non-surgical therapeutic approaches have been proposed to manage this complex-multifactorial condition. Anti-infective and regenerative therapeutic strategies were used to restore the peri-implant health as well as to achieve new bone-to-implant contact.
