**8. Conclusion**

The osseointegrated implant interface remains in a very delicate balance where adverse individual tissue reactions may combine with the foreign body reaction to cause unwanted sequel in form of marginal bone loss or implant failure. There are many other predictable factors leading to implant failure. Thus, to get this spectrum high up on success of dental implants, apart from the factors of implant design, osteotomy site preparation and the available bone, the addition of biomimetic molecules to the host tissues has been abundantly researched however the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw a robust conclusion.

The autologous preparation, dense concentration of growth factors and affirmative (*in vitro, in vivo and animal)* study results has opened avenues of their progressive research in dental implantology. This can be a boon for hosts receiving any kind of surgery, who have an underlying systemic/metabolic compromise. Many human studies and trials are also underway for devising carriers for these bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.
