**4. Conclusion**

The development of autoimmunity is defied by a wide range of mechanisms, regulatory cells and tolerance mechanism, which when not properly functioning or are inefficient, fail to decelerate the effects of the interplay of environmental, genetic, and immunological factors. Faults in the immune tolerance mechanism consequentially leads to inappropriate cell death or survival or failure to clear debris which are involved in the pathogenesis of autoimmune diseases. The failure of these systems and the eventual development of autoimmune diseases is aided by inflammatory modulators. Interestingly, this process occurs before the full development of diseases, making the modulators a potential therapeutic target. As such, they can also be used as control points to prevent the exacerbation of the autoimmune diseases. Targeting inflammatory modulators can, therefore, offer opportunities for the development of novel diagnostic methods and effective therapy in the future.

*Reactive Oxygen Species in the Development and Resolution of Autoimmune and Inflammatory… DOI: http://dx.doi.org/10.5772/intechopen.99988*
