**4. D-linalool**

A similar fragrance is found in lavender, but in a cannabis cultivar and when phytochemically available, the synergy between cannabinoids and this monoterpenoid reveals treatments such as sedative-like effects. Linalool is used as a local anesthetic; an anti-convulsant, a powerful antileishmanial agent. Linalool is an antinociceptive, reversing defects and spatial memory and learning at high doses with a respectable contradiction in short- and long-term recognition memory. This implies detrimental to cognitively impaired sentient beings, though studies were done on healthy and cognitive impaired rats [9, 27, 28].

The NMDA receptor is very important for controlling synaptic plasticity and memory function. Specifically, linalool showed strong efficacy in inhibiting glutamate uptake in cortical synaptosomes and decreased extracellular glutamate availability via inhibiting the release or adding to the uptake [29, 30]. NMDA affinity means GABA will be either used or suppressed; and in the study, reduced morphine opioid dependency [29, 31].

**Does D-Linalool contribute to the paradoxical effect?** Linalool acts as a competitive antagonist of [3 H] glutamate binding and as a noncompetitive agonist of [3 H] dizocilpine (NMDA antagonist) [32, 33].

**Conclusion (plausible):** More study must be done to further identify linalool pathologies and how they may have representation in a paradox in brain plasticity.
