**Abstract**

Here in part two, a brief explanation in essential oil/ terpene administration as well as cover the medicinal effects of terpenes focusing on biphasic pharmacokinetics and possible paradoxical reactions and molecular sites of interest, including the medicinal properties of a specific flavonoid; an explanation into the paradoxical entourage and identifying common misconceptions from cannabis use and education; we finalize our look into the paradoxical location learning biphasic and paradoxical reactions from cannabis with an in-depth look into the cause of ASR/ATD following with a fundamental explanation how stress with the wrong medication can instigate the situation. The **Multi Cultivar Entourage Effect Chart** (**MCEEC**) directed goal was to unravel multiple cultivars bioavailability to then combine and create a more robust and stronger entourage being pulled from multiple cultivars with specific bioavailability of cannabinoids, terpenoids, and flavonoids necessary to treat any specific indication. Indirectly the chart also identified inter-entourages, more importantly, "antagonistic" inter-entourages. By helping a patient describe their reactions, understand, identify and track terpenes and cannabinoids that cause specific reactions, the patient will be able to identify a profile that works for them, which gives an explanation and solution to identifying how to manage cannabis medication for the patient along with conclusion and thoughts.

**Keywords:** Advanced Synergistic Serotonin Release (ASSR/ASR), Advanced Tryptophan Depletion(ATD), Endo-Cannabinoid System (ECS), Central Nervous System (CNS), Psychoactive (PA), Non Psychoactive (N-PA), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Tetrahydrocannabinolic Acid (THCA), Tetrahydrocannabivarin (THC-V), Cannabinol (CBN), Cannabichromene (CBC), Cannabielsoin (CBE), Cannabicyclol (CBL), Cannabidiol (CBD), Cannabidiolic Acid (CBDA), Cannabidivarin (CBDV), Broad Leaf Marijuana (BLM), Broad Leaf Marijuana Dominant (BLMD), Medium Leaf Marijuana (MLM), Narrow Leaf Marijuana Dominant (NLMD), Narrow Leaf Marijuana (NLM), Cannabinoid Receptor type1(CB1), Cannabinoid Receptor type 2 (CB2), Vanilloid Receptor 1 (TRPV1), Transient Receptor Potential Ankyrin 1(TRPA1), γ-aminobutyric acid (GABBA-A), Hydroxy-Tryptamine (5-HT), Transient Receptor Potential cation channel, subfamily V, member 3 (TRPV3), Attention Deficit Hyperactivity Disorder (ADHD), γ-aminobutyric acid (GABAA)

### **1. Introduction**

#### **1.1 Terpenes and flavonoids**

This section's objective is to weed out possible terpene synergies which may actuate a biphasic experience of either ASR/ATD. Over 200 terpenoids are primarily responsible for the many fragrances of cannabis and may represent 10% of trichome content [1–7]. Monoterpenoids, containing oxygen functionality or missing a methyl group, are commonly composed of limonene, myrcene, pinene, linalool [8–11]. Terpenes are widely known to cross the blood–brain barrier due to their chemical makeup to be lipophilic like cannabinoids [9]. Terpenoids will begin to break down before the processing stage at a rate of about 5%. After curing processes and in time (1–6 months) terpenoids will have diminished significantly [12, 13]. With this in mind, any further actions taken to separate the whole cultivars' phytochemistry undoubtedly weakens the quantum function of the entire medicinal chain, ie extraction and or isolation processes. Terpenes in their natural state, are incorporated in the trichomes of cannabis with a fundamental directive whether it's to keep predators at bay, maintain general cultivar homeostasis, or the more commonly known use, as a medication for homeostasis in most vertebrate species.

Any medicinal flower sold past 6 months from the end of the curing stage, will most likely be under the promised genomes bioavailability or true to the cultivar medicinal properties. The cannabis flower should be tested at the 6 month and interpened to either be converted to extracts or discarded unless properly stored (i.e., time would vary depending on consumer storing methods). In this time (1–6 > months), the main subsidies of most terpenes begin to chemically change and fall under generally categorized oxidized terpenoids or hydro-carbon terpenes. Cannabinoids in contrast are more resilient in this oxidative manner but should be understood that the intentional entourage from any cannabis cultivar should be consumed as a whole, not a hand-me-down to what was. Other constituents of terpenoids such as caryophyllene, geraniol, humulene, limonene, linalool, myrcene, ocimene, pinene, terpineol, and terpinolene have beneficial health properties that help to treat indications ranging from neurodegenerative disorders to cancer. Though terpenes never directly affect CB1 or CB2, their presence in an entourage may mediate other possible synergistic effects, along with serotonin release.

Flavonoids, a secondary metabolite and interestingly anthocyanin (i.e., blue, violet, and red plant pigments that exist in fruit, vegetables, tea, wine, and "more recently researched," cannabis) intake have had extensive research ranging from antiinflammatory to pro-cognitive explained characteristics which also include passing the blood–brain barrier [9]. Thus, it has a viable and crucial part in medical cannabis as a whole product. Specific fruits with high levels of anthocyanins will display dark purple, blue, and perceptively black pigments through inflorescence; like in cherry juice or from Japanese plums, similar phenolic compound levels can be comparable to hemp seed extract. Cannabis displaying plentiful purple or deep red inflorescence could then be suggested for a different or new method of extracting with possible uses such as tinctures, teas, or juices as to not cause excessive degradation to the bioavailability of said cultivar medical administration.
