**1. Introduction**

When visiting a medical marijuana dispensary, it is common to hear, "try and see what works for you." Unfortunately, in today's cannabis industry, some physicians and most bud tenders or "patient care specialist" have to tell patients to go through a trial and error process until they figure out what works best for their indications. This can be very stressful and unfortunate since no single cannabis cultivar strain is the same; implying there is no consistent structure or knowledge or actual prescription while being treated with cannabis.

What numerous studies in this paper show are that specific indications (i.e., physical, mental, neurological disruptions that slowly degrade the quality of everyday life) seem to respond best to specific entourages of cannabinoids and terpenes within a sub-specie ballpark grouped cultivar similarity. Such Cannabis sub-specie groups will be described in the mannerism of an Interpener (Cannabis Sommelier) to guarantee fundamental accuracy of sub-specie variation, chemotype, phenotype, and genotype, which was modified by Trichome Institute based off the study of Clark and Merlin (Evolution and Ethnobotany).

There is a common misconception about what constitutes a Cannabis Indica strain and its sub-specie variations. To understand the mechanisms associated with cannabis, it is important to separate the whole to understand how to consume properly for any specific indication.

A substantial amount of named genetics from growers and their companies are unfortunately carried out through the whole seed-to-sale process claiming the term "Indica" when in actuality is most likely an Indica leaning Hybrid/BLMD. Reasons for Sativa not being a part of this paradox is that sativa is known to excite, and haze has been known as the couch lock of sativa (most likely due to specific terpene profiles). There has never been an identification for Indicas that cause stimulation (what is now known as the terpene profile and chemovar sub-specie to denote cannabis's therapeutic effects). This could be claimed as "stoner myth" since it may have been considered unfavorable cannabis that made people paranoid or anxious, hence another reason to look into the paradoxical effect.

This simple misconception causes improper strain speciation leaving a patient to improperly consume. Ultimately, cannabinoids, terpenes, and other minor phytochemicals are what dictate how cannabis will react in the human body. Ignoring that and only judging by genetic names or suggested sub-specie can result in unintentional wrong profile. This is obviously unacceptable for any terminal patient as much as it is unacceptable for patients with indications such as panic attacks, neurodegenerative disease, or those on the spectrum.

Individuals who have the propensity to experience the "paradoxical effect" where the patient experiences agitation from an implied "sedative and/or stimulant" may also need to consider how an individual metabolizes said entourage from any cultivar administered medically or recreationally; different cannabinoids and terpenes metabolically break down at varying rates within the body.

I hope this paper will provide the information that will pave a new road for patient care. Additional research is underway to identify those patients with the propensity

*Marijuana, a Journey through the Endocannabinoid System: Unmasking the Paradoxical Effect… DOI: http://dx.doi.org/10.5772/intechopen.101555*

toward a paradoxical effect or ASR/ATD from stimulants or sedatives depending on neurological and physiological disabilities that are tied to the brain and disrupt the regulatory process it takes for homeostasis in any human.
