**5. Beta-Caryophyllene**

Beta-caryophyllene sesquiterpenoid, in studies, has shown to operate in a "Phytochemical Polymorphism" manner [34]. With this in mind, Ethan Russo cites, "Terpenoids are pharmacologically versatile: they are lipophilic, interact with cell membranes, neuronal and muscle ion channels, neurotransmitter receptors, G-protein coupled (odorant) receptors, second messenger systems, and enzymes" [35, 36]. To be understood as a helper to bioavailable cannabinoids and could be thought of as an oil change for a car.

**Does caryophyllene contribute to the paradoxical effect?**

**Conclusion:** No pathology to denote a paradoxical behavior unless serotonin levels are sub-par.
