**3. β-Myrcene**

β-Myrcene, a monoterpenoid with analgesic, muscle relaxant, and sedative-like properties with many cannabinoid synergies i.e., CBD, THC, CBG. Myrcene can display analgesia in mice, but synthetic drugs that block opioid receptors in the nervous system can be blocked, perhaps via the α-2 adreno-receptor [15, 23, 24], which is responsible for inhibiting the release of norepinephrine (noradrenaline) in a form of negative feedback i.e., "sedation" [25]. Agonists of these receptors have been used to treat mainstream medical conditions such as hypertension, ADHD, various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and surprisingly nicotine cravings, which is one of the most addictive chemicals known to humans [26].

**Does β-myrcene contribute to the paradoxical effect**? Yes, if there are sub-par levels of serotonin in the body.

**Conclusion:** A given sedative, myrcene does depend on serotonin for endogenous opioid production, hence, if there is a depletion in tryptophan, then there will most likely be a paradoxical reaction.
