**10. Conclusion**

Sea buckthorn can be considered as a functional ingredient for use in cosmetics, dietary supplements, general foods and fortified foods due to its richness in antioxidant molecules, in vitamins C, A and E, in omega 3, 6, 7 and 9, and a diversity of bioactive molecules. Its polyphenolic compounds include phenolic acids, flavonoids, carotenoids associated with antioxidant, anti-inflammatory, antibacterial and anticancer properties. SB exerts cardioprotective effect including antiatherogenic properties, hepatoprotective and neuroprotective effect, improves metabolic profile (lipid profile, glycemic control, blood pressure, fat mass and waist circumference), protects against acute lung injury, and supports tissue regeneration (**Table 2**).

As a consequence, sea buckthorn offers an excellent source of bioactive molecules [3] that could enter in the formulation of nutritional beverages, yogurts, muesli, healthy snacks and bars, in dietary supplements or instant powder mixes as a superfood ingredient. SB polyphenolic extracts such as Stemberry® standardized for polyphenols and



**Table 2.**

*Summary of health benefits of sea buckthorn berry, seed and leaf.*

more specifically proanthocyanidins, demonstrated significant regenerative properties through a stimulation of endogenous stem cell mobilization, which has demonstrated therapeutical benefits in neurodegenerative disease, heart diseases, diabetes, and chronic inflammatory diseases by supporting the body's natural repair system. Additional studies on the regenerative effect of SB polyphenol fraction in several diseases such as diabetes, neurodegenerative, cardiovascular diseases could open new complementary therapeutical strategies in order to improve patients' quality of life [53].
