**5. Finding the paradox**

To find, understand, or even combat the paradoxical effect, one must first determine why the incorporated cannabis profile produces the experienced reaction. Whether it is the profile itself or the person who is being treated, acknowledge preexisting psychological and/or physiological aspects systemic or invoked, and then figure out how to counteract the symptoms so the goal for homeostasis works in the way it is intended.

In this section, some of the most common indications that respond to cannabis will be discussed. In addition, the clinical research studies addressing the impact of various cannabinoids on pain have been conducted throughout the world including Bangladesh, Canada, Columbia, Finland, Germany, Italy, North Korea, Poland, Portugal, Spain, Sweden, the United Kingdom, Uruguay, and in much of the United States. The traditional approach to pain management has led to a significant increase in opioid abuse and addiction. More recent studies have focused on the use of marijuana and resulted in decreasing the use of opioids for pain, reducing the withdraw symptoms from opioid use, and increasing the quality of life for patients [56]. Many patient surveys have been conducted in the States that allow marijuana. These surveys clearly indicate that patients reduced their use of opioids; in a New England survey, the respondents reported using less opioids (a 75% reduction) as well as reducing other medications used to treat anxiety, migraines, and sleep disorders after starting medical cannabis [57].

*Marijuana, a Journey through the Endocannabinoid System: Unmasking the Paradoxical Effect… DOI: http://dx.doi.org/10.5772/intechopen.101555*
