**Abstract**

Phenolic compounds represent one of the secondary metabolites of plants with pharmaceutical and therapeutic applications. Flavonoids, quinones, bioflavonoids, neolignans, xanthones, curcuminoids, tannins, and coumarins are some examples of the major groups of commonly available phenolic compounds in our daily foods, beverages, and spices. From this standpoint, the Liver Research Laboratory (FAB Lab) at Mansoura university, Egypt, established a multidisciplinary research (chemistry, molecular biology, bioinformatics, pharmacology, and pharmaceutics) based on utilization of commonly abundant natural products from plants and agricultural wastes, especially phenolic compounds to meet the goal of applied scientific research in pharmaceutical industry, environment, public health, and to furnish a sustainable well-developed globe. Examples of our concerted efforts, for over 30 years, are in the area of natural products and utilization of environmental waste containing phenolic compounds for various health disorders (cancer, cataract, degenerative diseases, hyperpigmentation, hyperglycemia, skin disorders), nano-, green and click chemistry. This chapter presents a practical model from FAB-Lab to maximize the benefits from phenolic natural products that have not been optimally exploited to establish meaningful scientific applied research. Patents, innovations, and significant publications indexed by the Web of Science and Scopus databases in the journals that occupy the 1st and the 2nd quartile will be presented.

**Keywords:** phenolic compounds, green chemistry, environment-friendly industry, therapeutic applications
