**8. Quality control, GMP and cGMP**

Quality control (QC) is known as maintaining the quality and authenticity of anything related to the research or laboratory work like cell, media, PBS, Polymerase chain reaction (PCR), or RT-PCR report. That's why the QC department, as well as personnel are important. Every life science researcher ought to know and aware of the current Good Manufacturing Practice (cGMP), QC process and system. QC, GMP, and cGMP have the same objectives and more or less same activities. In GMP and cGMP all are the followings clearly defined- Rules, regulations, and guidelines; good implementation; all aspects of the product's lifecycle and manufacturing process; product development and raw materials selection to the final production process; testing; storage, and shipment. The worlds policy maker organizations like FDA, Medicines & Healthcare Regulatory Agency (MHRA), WHO, European Union (EUDRALEX)-UK, approved all the guidelines of cGMP. Recently GMP is prescribed as "cGMP". The "c" stands for "current" as a reminder that all the techniques, systems, all the processes must be kept up-to-date to consent to the most recent regulations. [42]. cGMP guidelines ensure excellent quality at each step of work. It acts as a safeguard for the quality, purity, strength and identity of cells and related products. This guideline helps to construct a consolidated quality control and management system, helps to hold raw materials quality, helps to develop good SOPs, helps to a build a system of product quality investigation and deviation measurement, and take part in the building of reference laboratories for testing. The necessity of cGMPs are always keep in mind because it is very much important to establish QC. Numerous pharmaceutical companies are executing modern and comprehensive quality control systems and risk management system as a result they hold their quality above the average standards [43]. Quality control (QC) is employed in the GMP framework. Using a broad array of analytical techniques, the QA (Quality assurance) team will identify and quantify all the factors deemed critical for any specific product. Biological products require extensive analysis for characterization. There are some cations related to QC [44] such as-

