**4.20 Bulk antigen and vaccine candidate development**

A large scale of virus production is known as bulk antigen production. A Proper culture of the cell, passaging, infection of cell-based on required MOI by a specific virus, harvesting, filtration of the virus, QC test, and COA gives the final confirmation regarding the virus and the process. After formulation, dosing should be done with the help of bulk antigen that helps to develop proposed vaccine candidate based on reference manual, and guidelines.
