**1.2 Why are EVs so exciting?**

EVs are generating excitement within the field of gynecologic oncology because they not only help researchers to better understand how cancers grow and spread but also because they can assist with the diagnosis and management of EOC at every step of the disease course. EOC EVs carry a wide array of information including microRNA (miRNA), non-coding RNA, messenger RNA, DNA, lipids, glycans, and proteins that play a role in the proliferation and metastasis of this disease. In fact, patients with EOC are known to have an upregulation in EV secretion, transforming the microenvironment surrounding the cancer and causing normal cells to secrete tumorigenic factors [10]. Researchers will someday be able to detect EOC EVs readily in blood or urine for early detection of the cancer so that clinicians can treat it at an earlier stage, preventing metastasis and resistance to chemotherapy from ever occurring. By understanding the information carried inside of EVs, patients will have access to personalized treatment regimens specifically tailored to their cancer. By exploring

different ideas, scientists will be able to unlock the potential for EVs to provide dramatic breakthroughs in the diagnosis and treatment of EOC.
