**3. Extracellular vesicles as biomarkers**

During the 1990s National Institute of Health (NIH) has explained biomarker as a biological molecule or gene that is found in body fluids estimated as a marker of a biological, pharmacological, pathogenic process for therapeutic intervention [21]. EVs are systematically involved in intercellular communication and exhibited as qualitatively and quantitatively in diseases like cancer, it also plays a significant role
