**6. Conclusions**

Exosomes are endogenous tiny vesicles that enable communication between neighbor or far cells [63]. Exosomes originating from various origins can be initiated in circulation and target specific cells inside distant tissues [64]. Because of its stability and capacity to bypass natural barriers. Exosomes are a suitable and potential nanocarrier vehicle for cancer immunotherapy and chemotherapy because of their characteristics. However, exosomes are demonstrated to be involved in the triggering of

immune responses towards cancer cells and stable of an immunosuppressive milieu. The qualitative and quantitative data of EVs molecular signatures are mandatory in extra cellular-based tumor diagnosis, monitoring, and therapeutic delivery to distinct cancer subtypes. As previously stated, researchers are most interested in EVs and therapeutic targets. However, much more research on these EVs for cancer immunotherapy and chemotherapy is needed to gain a better understanding. In the view of EVs have received great attention and would be a potential and promising biomarker and a better candidate for the treatment of deadly disease, cancer.
