**6. Conclusions**

It is becoming increasingly evident that EVs are involved in a multitude of biological processes and can play modulatory and regulatory roles. If one adds their new potential as biomarkers for various diseases and their therapeutic delivery cargo abilities, it is certain that one cannot over neglect their ability to support stem-cellbased therapies. Future avenues are seen at the horizon when further research will probably allow us to use engineered-EVs to support endogenous repair and thus create a modern regenerative medicine.
