**8. "Remodeling" at the vascular level of malignant tumors**

The local tumor progression is also facilitated by the production of a new vascularization with "neogenesis vessels" as shown in **Figure 7**. The neoformation vessels have an increased permeability, that facilitates the process of remote metastasis. At the tumor level occur several processes such as angiogenesis, lymph angiogenesis, vascular permeability, and all the consequences of these processes (tumor hypoxia, vascular fragility, aggressiveness) [6].

The action of radiotherapy at the level of tumor vascularization allows a normalization, that is, a vascular "remodeling" with all the advantages resulting from

#### **Figure 7.**

*Processes induced at the tumor vascular level and the possible vascular "normalization" through therapy (chemotherapy and radiotherapy) [2].*

it (better oxygenation of tissues, more efficient action of cytostatics and radiation, reduction of hemorrhages).
