**7. Wound healing and tissue repair process**

Besides the tumor destruction by radiotherapy which includes the remodeling process to normalize the ECM, in which the tumor cells were killed, an additional process defined as wound healing, that includes the process of restauration of the processes produced by the irradiation of the normal tissues around the tumor, or in the tumor bed, described as acute and late side effects is present.

#### **Figure 6.**

*Left side: Stages of the process of healing after surgery and radiotherapy with their overlapping (on the time scale): Inflammatory phase, proliferation, and tissue remodeling with collagen accumulation in the terminal phase [9]. Right side: Overlapping of wound healing [10].*

*The Remodeling in Cancer Radiotherapy DOI: http://dx.doi.org/10.5772/intechopen.102732*

The complexity of the "healing" after surgery and the tissue repair process after radiotherapy, with the representation of the 4 phases of healing that are partially overlapping, is shown in the figure (**Figure 6**).
