**3. Conclusions**

Salivary exosomes provide viable, consistent and stable sources of cancer biomarkers. The scope of its utility as well as understanding the molecular mechanisms which underpins it, requires further investigation. Future studies refining the methodology for extracellular vesicle isolation and cleansing presents the greatest challenge that is needed to overcome the restrictions to exploring the full scope of salivary exosomes in systemic diseases including oral cancer.
