**Abstract**

One of the most prevalent forms of oral cancer is oral squamous cell carcinoma (OSCC), a major cause of morbidity and mortality worldwide. Following a definite oral cancer diagnosis, OSCC is typically treated with a multidisciplinary approach including surgery, chemotherapy, and radiation. In contrast, conventional chemotherapy medicines may be ineffective and have a range of side effects. Many techniques have been proved and authorized for treatment and diagnostics of different types of oral cancer, while others are currently being investigated in clinical trials. This book chapter is aimed to explain the current preclinical status of nano-based techniques to successfully diagnose and treat OSCC. This book chapter would also emphasize recent theranostics approaches utilized to cure OSCC. Nanotechnology also improved cancer biomarker detection, making them faster and more sensitive. To overcome these constraints and improve *in situ* drug delivery, various nanoparticles have been employed as innovation drivers.

**Keywords:** squamous cell carcinoma (OSCC), matrix metalloproteases (MMPs), magnetic nanoparticles (MNPs), HSC-3 cells, vital protein endothelial growth factor (VEGF), C-reactive protein (CRP)
