**5. Radiobiology of radiosurgery**

Radiosurgery, invented by Prof. Lars Leksell, has been regarded as a significant treatment of choice in patients with intracranial neoplasm, since December 1967, when the first patient suffering from craniopharyngioma was treated with the prototype Gamma Knife at the Sophiahemmet Hospital in Stockholm, Sweden. Radiosurgery is the use of ionizing radiation to treat patients with neoplasm by delivering a precisely measured dose of irradiation to a defined tumor. The main aims include the followings:


The difference between radiosurgery and radiotherapy generally is the size of the treatment volume, and the dose delivered during that single session. While volume is important, it is the radiosurgery team in achieving a precise and accurate radiation plan. Radiosurgery allow high dose per fraction which results in a higher biologically equivalent dose to the target without increasing the risk of complications in

*LINAC stereotactic radiotherapy 25 Gy in 5 fractions for treatment of left petroclival meningioma in our centre.*

#### *Overview of Radiosurgery for Intracranial Meningiomas DOI: http://dx.doi.org/10.5772/intechopen.100006*



