**1. Introduction**

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in adults, the fifth most common cancer in the world and also the third most common cancer of cancer-related deaths [1]. It is the malignancy of hepatocytes with varying degrees of differentiation [2]. The most common cause of death in patients with HCC is cirrhosis. Despite all the unknowns, heptocarcinogenesis is a multistep process, and chronic inflammation plays the major role [2–6].
