*2.4.4 Long noncoding RNAs (Inc RNAs)*

Recent evidences have shown that long noncoding RNAs (lncRNAs) are involved in cancer diagnosis and prognosis. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and AUC for lncRNAs in the diagnosis of HCC were 0.83, 0.80, 4.2, 0.21, 20, and 0.88, respectively [42].

**Table 5** summarizes newer biomarkers under evaluation for diagnosis of HCC.
