**3.2 Regorafenib**

Regorafenib is another TKI that has been utilized as a second-line agent in advanced HCC [18, 34, 35]. The RESORCE trial along with other studies support the use of regorafenib in treatment-resistant advanced HCC with active investigations focusing on applying the use of regorafenib in combination with other medications against advanced HCC [36]. When comparing cabozantinib and regorafenib as second line therapy in patients who had failed sorafenib therapy, the side effect profile of these medications was similar (with only increased incidence of diarrhea in patients taking Regorafenib), and both therapies provided similar benefits in regard to OS and PFS [37].
