**Acknowledgements**

Our studies shown in this chapter were partially supported by Grant-in-Aid for Scientific Research on (1) Innovative Areas "Will-Dynamics" of The Ministry of Education, Culture, Sports, Science, and Technology, Japan (JP16H06403 to T.A.K.), (2) The Japan Agency for Medical Research and Development (AMED) (JP19dk0307047 & JP19dk0307075, JP19dm0107095, and JP21wm0425010 to T.A.K.), (3) KAKENHI - the Japan Society for the Promotion of Science ("Wakate A" JP26713039 and "Kiban A" JP18H04042 to T.A.K.) and (4) SENSHIN Medical Research Foundation (to T.A.K.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
