**5.3 Pulmonary**

The lung is a potential target for drug delivery for both local and systemic treatments. Locally, lung and respiratory diseases, e.g., lung cancer or tuberculosis, can be treated with a reduced dose and fewer side effects compared to conventional dosage forms. At the systemic level, due to the large surface area of the lung, the drug can be absorbed quickly and efficiently without being degraded by the firstpass metabolism as in oral administration [118]. In 2015, Kim et al. [113] prepared cisplatin-loaded SFN for the treatment of lung cancer. The particles showed compatibility with the human lung epithelial cell line A549. The results indicated that the cisplatin loaded in the particles increases the cytotoxicity concerning the drug applied alone. The researchers concluded that the particles showed a high aerosolization performance through in vitro lung deposition measurement, which is at the level of commercially available dry powder inhalers.
