**Abstract**

Antimicrobial resistance (AMR) is a global threat worldwide. Inappropriate and irrational use of antibiotics are the responsible causes for the development of AMR in the pathogenic microorganisms. In the developing countries like India the data encountered a higher burden of resistance in the rural communities. In such scenario the AMR may lead to difficulty in treatment of various ailments among human as well as companion livestock. In India cows and buffalo are considered as companion livestock. However the definition of companion livestock is slightly different in the developed countries. Most of the rural population in India is dependent on the livestock for their livelihood as the dairy farming in the rural community may contribute in the financial status of the rural population. *Staphylococcus aureus* (*S. aureus*) is one of the foremost causative agent of skin and soft tissues infections among humans as well as in companion livestock. The situation is further complicated by methicillin resistance in *S. aureus*. The carriage of MRSA by humans and companion livestock may lead to further AMR spread to the community. In the civic health point of view, it is important to initiate appropriate interventions to tackle the problem at the rural population.

**Keywords:** Companion livestock, Antimicrobial resistance, *Staphylococcus aureus*, Methicillin resistant *S. aureus*, Rural India, LA-MRSA
