**1. Introduction**

Many recent studies demonstrate that most nanoparticles (NPs) show an adverse or toxic effect on blood cells. Researchers have found that administration of ZnO nanoparticles (pH< 7) to whole blood samples and blood serums of animal and bird cause damage to the blood cells and tissues [1]. But NaOH are added to the acidic solution of ZnO to make the solution alkaline (pH=7.2) [2]. This alkaline nanostructured ZnO solution when added to whole blood and blood serum does not deteriorate the blood cells due to which biological parameters such as – Serum glutamic pyruvic transaminase (SGPT), Serum glutamic oxaloacetic transaminase (SGOT), Blood Urea Nitrogen(BUN) and creatinine can be more efficiently observed for different animals such as –cow (Class-Bovine).

Now a days nanoparticles based biosensors are introduced for obtaining the desired results more efficiently [3]. There are different types of biosensors which are incorporated with nanoparticles for diagnosing different problems in biological field [4].
