**4.3 Particular sensibilities**

Loss of taste and smell and changes in smell and taste are common complaints that are difficult to quantify accurately, and quantitative procedures are not always practical. Despite the frequent involvement of organic solvents, this illness lacks a well-defined pathophysiological basis. Among the problems inherent in quantifying taste is that olfaction plays a significant role in detecting food's "flavor" and "perfume," even though many of us would categorize these as tastes. Changes in taste perception are frequently connected with administering a variety of therapeutic medicines. However, they are typically reversible. Although hearing loss has been associated with using organic solvents, particularly toluene, it is more usually associated with well-known ototoxic drugs such as aminoglycosides [6, 7].
