**4.6 Skeletal muscle**

Skeletal muscle injury is rather infrequent. The bulk of toxicological problems in skeletal muscle is the result of genuine denervation. Several myotoxic substances, including clofibrate and related compounds such as insecticides and organophosphates, can cause substantial muscle loss by rhabdomyolysis. Diazacholesterols and herbicides containing chlorophenoxyisobutyric acid stimulate myotonic activity, whereas licorice, diuretics, and excessive alcohol use induce hypokalemic paralysis. Skeletal muscle regenerates rapidly following the removal of the causative factor. Rhabdomyolysis's most important acute clinical consequence is a significant risk of acute renal failure [6–9].

## **4.7 Psychiatric and Behavioral disorders**

Depression is the most frequently reported symptom of neurotoxic diseases in patients. These individuals frequently express feelings of depression, anxiety, and forgetfulness. While the psychological signs of aluminum toxicity are normally mild, they can progress to severe dementia and parkinsonism/dementia syndrome. Lithium overdose with lysergic acid diethylamide may result in cerebellar ataxia, dementia, and severe psychotic illnesses (LSD). Due to widespread disdain for psychiatric/psychological disorders, there is a dearth of reliable knowledge regarding the diagnosis, management, and prognosis of mental health complaints associated with such intoxication. Additional study on the acute and chronic effects of neurotoxic drugs on cognitive function is necessary [6, 7].
