**3.3 Composite eyelid score (CES) and change of compound eyelid score (CCES)**

A Composite Eyelid Score (CES) was compounded based on the presence or absence of five abnormal anatomical features of the eyelids: (1) hyperemia of anterior lid margin; (2) thicken lid margin; (3) rounded lid margin; (4) hyper-keratinization of the lid margin; and (5) telangiectasia around meibomian gland orifices.

These five features were evaluated at BL and FU. Each one was sub-scored 1 if the abnormality was present, or 0 otherwise. In the analysis, CES was calculated as the sum of these five sub-scores, thus ranging from 0 (all five features absent) to 5 (all five features present). At FU, the examiner used photos of the eyelids captured at BL to determine whether there was an improvement (+1), no change (0), or a deterioration (21) for each of these features. The sum of these five sub-scores, ranging from 25 (if all five features deteriorated) to +5 (if all five features improved), was defined as the Change in CES (CCES).
