**3.2 Beta-blockers**

The Beta-blockers, for many physicians, is the second choice for controlling intraocular pressure, has been shown ocular discomfort due to burning, hyperemia, toxic keratopathy, superficial punctate keratopathy (SPK), periocular contact dermatitis, and dry eye [14].

SPK was the most common finding with surface staining. It was reported in 6% of patients using timolol.

Other reported effects of timolol is the decreases tear production. This effect is quantitatively limited and does not appear dangerous for normal eyes, although it may become so for eyes with an originally low lacrimal secretion [15].
