**Acknowledgements**

We grateful the Coordination of Superior Level Staff Improvement (CAPES) – Finance Code 001, Oswaldo Cruz Institute (IOC), and Post-graduation of Sciences and Biotechnology PPBI), and Federal Fluminense University (UFF)**.** This work was supported by CNPq (National Council of Research of Brazil) (RXF holds a grant with Fellowship Process Number 308755/2018-9), CP holds a grant from the Brazilian agency CNPq. FAPERJ (Research Support Foundation of the State of Rio de Janeiro) (JCNE (Young Scientist from Our State) with Fellowship process number E-26/203.246/2017) and Emergent Group of Research from Rio de Janeiro (E-26/211.025/2019).
