**Abstract**

The high number of cases reported of antibiotic resistance use and mortality due to gram-negative sepsis, triggered the development of natural agents to be used in the prevention and treatment of sepsis. Studies continue to be developed on the use of tropical fruits such as coconut fruit and kaffir lime fruit which contain high antioxidants and many potential compounds. Recent experimental data has proven that the high antioxidant activity found in the coconut fruit mixture, namely processed fruit flesh and coconut water and added kaffir lime juice, can be used as an immunonutrition agent that can improve body physiology and can increase the survival rate of test animals from endotoxemia lipopolysaccharide induced by Eschercia coli intraperitoneally. This chapter provides an overview of the potential of natural products that can be used as immunonutrition preparations. Finally, this provides information showing the importance of the intake of immunonutrition in conditions of sepsis infection.

**Keywords:** sepsis, natural product, immunonutrition, coconut fruit, kaffir lime
