**2.1 Oxygenation**

Intubation and mechanical ventilation (MV) may be required to support the increased work of breathing that typically accompanies sepsis. Oxygenation should be monitored continuously with pulse oximetry. Once MV is indicated, rapid sequence intubation (RSI) should incorporates a rapidly acting sedative (ie, induction) agent, in addition to a neuromuscular blocking (ie, paralytic) agent, to create optimal intubating conditions. Then ensure analgesia sedation throughout the duration necessary for the sepsis/septic shock management while regularly monitoring the possibility of weaning from ventilator.
