**5. Conclusion**

The inflammation field encompasses broad aspects, such as chemical mediators (cytokines, vasoactive amines, and lipid mediators), pain, and edema. The plasma membrane receptors influence on the inflammatory process is widely explored in scientific research. Concerning data discussed in this chapter, membrane receptors are promising and directly involved in the inflammatory mediators modulation in the edema and hyperalgesia pathophysiology. Thus, these new data open a horizon in the search for new pharmacological targets with anti-edema and analgesic effects in the therapeutic perspective of the inflammatory process.
