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## Meet the editor

Hassan S. Abduljabbar, MD, FRCSC, American Board Diplomate, is a professor at the College of Medicine, King Abdulaziz University, Saudi Arabia. He is also the president of the Saudi Society of Obstetrics and Gynecology and the Federation of Arab Gynecology Obstetric Societies (FAGOS). He is a referee for many international scientific journals. He is also an examiner for graduate degrees as well as for the Saudi and Arab board exams.

Dr. Abduljabbar has published more than fifty articles and edited three books.

Contents

**Section 1**

**Section 2**

**Section 3**

**Section 4**

*by Fred Chasalow*

*by Simmi Kharb*

*and Hemamalini Vedagiri*

Role of Vitamin D in Preeclampsia

**Preface XI**

Pathophysiology **1**

**Chapter 1 3**

Factors Affecting Preeclampsia **25**

**Chapter 2 27**

Cellular Function **37**

**Chapter 3 39**

Organ Dysfunction **53**

**Chapter 4 55**

Cellular Functions of ER Chaperones in Regulating Protein Misfolding and Aggregation: An Emerging Therapeutic Approach for Preeclampsia *by Janaranjani Murugesan, Ajithkumar Balakrishnan, Premkumar Kumpati* 

Preeclampsia: From Etiopathology to Organ Dysfunction

*and Mashael Abdulrahman M.S. Al Khelaifi*

*by Nissar Shaikh, Seema Nahid, Firdous Ummunnisa, Ifrah Fatima, Mohamad Hilani, Asma Gul, A. Al Basha, W. Yahia, F. Al Hail, H. Elfil, E. Abdalla, M.M. Nainthramveetil, M.A Imraan, Muhammad Zubair, Sibghatulla Khan, N. Korichi, S. Alkhawaga, H. Ismail, S. Yaqoob*

Role of Spiral Steroids in Pregnancy and Pre-Eclampsia

### Contents



Preface

Preeclampsia is one of the most common complications of pregnancy. It is characterized by high blood pressure and organ damage, most often of the liver and kidneys. Severe cases may cause hemolysis, low platelets and impaired liver function, kidney dysfunction, pulmonary edema, shortness of breath, and visual disturbances. Preeclampsia usually occurs in the third trimester but can occur as

Preeclampsia/eclampsia is one of the three leading causes of maternal morbidity and mortality worldwide. During the past 50 years, there has been a significant reduction in the rates of eclampsia, maternal mortality, and maternal morbidity in

This book includes six chapters. Chapter 1 discusses pathophysiology of preeclampsia, Chapter 2 describes how vitamin D deficiency can be a factor in developing preeclampsia, Chapter 3 deals with cellular changes that occur with preeclampsia, Chapter 4 describes how preeclampsia can lead to organ dysfunction, Chapter 5 explores the gestational endotheliopathy that may lead to complications,

and finally, Chapter 6 examines ophthalmic complications of preeclampsia.

**Hassan Abduljabbar**

Jeddah Fertility Center,

Jeddah, K.S.A.

Dr. Erfan & Bagedo General Hospital, Obstetrics and Gynecology Department,

early as 20 weeks.

developed countries.

## Preface

Preeclampsia is one of the most common complications of pregnancy. It is characterized by high blood pressure and organ damage, most often of the liver and kidneys. Severe cases may cause hemolysis, low platelets and impaired liver function, kidney dysfunction, pulmonary edema, shortness of breath, and visual disturbances. Preeclampsia usually occurs in the third trimester but can occur as early as 20 weeks.

Preeclampsia/eclampsia is one of the three leading causes of maternal morbidity and mortality worldwide. During the past 50 years, there has been a significant reduction in the rates of eclampsia, maternal mortality, and maternal morbidity in developed countries.

This book includes six chapters. Chapter 1 discusses pathophysiology of preeclampsia, Chapter 2 describes how vitamin D deficiency can be a factor in developing preeclampsia, Chapter 3 deals with cellular changes that occur with preeclampsia, Chapter 4 describes how preeclampsia can lead to organ dysfunction, Chapter 5 explores the gestational endotheliopathy that may lead to complications, and finally, Chapter 6 examines ophthalmic complications of preeclampsia.

> **Hassan Abduljabbar** Dr. Erfan & Bagedo General Hospital, Obstetrics and Gynecology Department, Jeddah Fertility Center, Jeddah, K.S.A.
