**8. Analgesia protocols**

The pain generation is a continuous process due to the nonadaptive property of the nociceptors. It depends on transforming the continuous noxious stimuli into the pain signals, transmitting the pain signals through pain pathways, and perceiving actual pain at the central level. Thus, pain treatment protocols should reduce noxious stimuli, interrupt pain pathways, and modify pain perception at the central level. Reduction in noxious stimuli generation is possible by addressing causative factors like inflammations and nerve injuries. Interruption of pain pathways is possible by blocking the transmission using the local anesthetic solution in RA techniques. Finally, modification of pain perception is possible using various

analgesic drugs mainly acting on the CNS level. A combination of various pharmacological agents, nonpharmacological techniques, and RA techniques constitutes the concept of multimodal analgesia. The components of MMA act on various levels of pain pathways.
