**3.5 Cases definition**

Most children with Covid-19 infection are asymptomatic or present mild symptoms, however, children who may develop a significant systemic inflammatory response have been identified, which may require hospitalization, ICU admission and even management for different medical specialties [55]. This syndrome, although it is a rare complication, can be fatal in children and adolescents. Due to the risk to the health of this population, it is necessary to characterize this disease and its risk factors, as well as to initiate immediate epidemiological surveillance. WHO has developed a preliminary case definition and case report form for MIS-C in children and adolescents. The preliminary case definition reflects the clinical and laboratory features observed in children reported to date and are used to identify suspected or confirmed cases (**Figure 1**) [56]. The National Institute of Health of Colombia, in its technical document of January 21, 2021, defines the operational concepts of cases as follows (**Table 1**; **Figures 2** and **3**) [57].
