*4.1.4 Glucagon like peptide receptor agonists*

Glucagon like peptide receptor agonist (GLP-1 RA) in animal studies has shown to activate ACE-2 expression and there have been speculations if this accelerated virus entrance into host cells but also if this expression neutralizes the virus limiting infection [25]. There is support for the hypothesis that GLP-1 RA may mitigate a more adverse clinical course in PWD and COVID-19 infection [26]. GLP-1 RA also are beneficial with weight loss. There are a few studies on GLP1RA and COVID-19 infection and even the final report of the CORONADO study did not find any benefit or harm with its use [27]. Dehydration is likely to lead to serious illness so patients on GLP1RA with COVID-19 should be monitored [15]. Regular meals and adequate hydration should be encouraged [15].
