**8. Conclusion**

The global impact of coronavirus disease is one of the heightening concerns of the present time. Though at this stage, it is not possible to determine the precise source of the coronavirus, however, the bats are considered as their natural hosts based on the available sequence based phylogenetic study. Genomic analysis revealed the arrangement of gene order and ORF positions. The largest genome RNA of coronavirus might be the reason behind the *intraspecies variability* and *interspecies transmission* via mutations and recombination mediated flexible genome modifications. Therefore, future outbreaks of zoonotic viruses cannot be overlooked. So, to avoid the future threat of zoonotic viral outbreaks, comprehensive measures should be planned alongside curbing this corona pandemic. In addition to this, the mutation acquired by the virus from time to time changes its pathogenicity is a concern. So a thorough study is essential to establish the relationship between the mutated forms of the virus with respect to the different geographical areas to predict the future genotypic pattern change of the virus. Further, in-depth investigations at individual protein levels of the virus are necessary to precisely predict the origin, to predict mutation mediated evolutionary selection pressure, and for a better understanding and development of the potential drug molecule binding efficacy.
