**Abstract**

COVID-19 pandemic has taken toll on the entire globe at physical, emotional and administrative level; straining each and every aspect to its fullest. As on April 19/2021, COVID-19 has infected more than 140 million people around world with around 3 million deaths worldwide. Covid-19 vaccine has emerged as an important direction to walk the world out of this crisis. This chapter covers the basic aspects and principles of vaccination and Immunology and its application in COVID-19 pandemic. This chapter further covers the different type of vaccines being developed, their dosage schedule and route of administration, common adverse events and myths related to them.

**Keywords:** COVID-19, Pandemic, vaccine
