**4.6 Hypogeusia/hyposmia: peripheral neurological findings**

The presence of taste and smell alterations seems to be a usual clinical manifestation going from 19.4–88% of patients [54]. The specific pathogenesis of these issues has not yet been explained. ACE-2 has been distinguished as the cell receptor for SARS-CoV-2. These receptors are expressed diffusely on the mucous membrane of the entire oral cavity, especially on the tongue and furthermore on the nasal mucosa where it takes part in respiratory inflammatory infections by regulating the level of inflammatory peptides, for example, bradykinin. There have been many reports regarding alteration of the senses of smell and taste. The one particular larger study, including a total of 417 patients with mild to moderate SARS-CoV-2 infection, described smell impairment in 85.6% and taste impairment in 88.8% [55].
