**3.4 Systemic organ failure**

There are many metabolic and pathological evidence of systematic impairment in different organs (heart, liver, gastrointestinal tract, and endocrine system) [35]. Hypoperfusion of the cerebrum could be impacted by a compromised function of the heart [36]. Many neurological symptoms, for instance, headache, confusion, agitation, can be correlated to systemic metabolic changes including electrolyte disbalance, hormonal dysfunction and accumulation of toxic metabolites [37, 38].
