**5. Final considerations**

Cardiovascular diseases (CVD) are one of the most important causes of morbidity and mortality in the world being a great challenge for clinicians and researchers in the context of COVID-19. The pathophysiological explanation suggests an intimate correlation between SARS-CoV-2 protein S and ACE2 receptors, which the virus takes advantage of to increase its ability to penetrate host cells. The aggression of the cardiovascular system can be divided into three hypotheses direct damage of the cardiomyocyte by the virus; hypoxemia due to lung injury or coronary events; or exacerbated immune response. When it comes to patients with COVID-19, the coexistence of previous cardiovascular diseases or risk factors such as hypertension, diabetes, coronary heart disease and heart failure, in addition to biochemical markers such as high troponin and pro-BNP seem to increase mortality.

Thus, when it comes to the cardiovascular system, these issues are aggravated and urge as a joint commitment from researchers, medical and governmental organizations to carry out more robust studies with bold methodologies aimed at mapping prognostic factors and assertive therapeutic approaches in the management of cardiovascular complications of COVID- 19.
