**1. Introduction**

In December 2019, unexplained cases of pneumonia were reported from the epicenter of Wuhan City in China caused by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The transmissibility and virulence of this virus quickly transformed it into the worst global pandemic of our generation. The viral pneumonia syndrome was then named coronavirus disease 2019 (COVID-19) by World Health Organization. The COVID-19 pandemic continues to be a major cause of mortality and economic impact throughout the world. It is predominantly a respiratory disease, with a range of presentations varying from asymptomatic to severe respiratory failure. SARS-CoV-2 is known to enter human cells through angiotensin-converting enzyme 2, which is expressed not only in the lungs but also in other organs, such as the cardiovascular system, thus explaining the wide range of symptom manifestations. Significant concerns relating to

COVID-19 and the cardiovascular system have been highlighted, with COVID-19 inducing multiple cytokines and chemokines resulting in vascular inflammation, plaque instability, and myocardial inflammation. Several biomarkers have been studied that have related to COVID-19 progression as well as short-term mortality [1]. Cardiac biomarker and their elevation in COVID-19 have been studied and shown as a reflection of myocardial injury, hemodynamic stress, higher burden of cardiovascular disease, and worse prognosis [2]. Cardiac biomarkers have been suggested as possible aids for clinicians treating COVID-19 and understanding the severity of the disease and prognosis of patients. In this chapter, we will discuss the pathogenesis, role of specific cardiac biomarkers, and their use in the prognosis and management of COVID-19.
