*3.2.2.7 Oral vitamin K antagonists*

The vitamin K-dependent MGP, despite not being related to blood coagulation cascade, is affected by Vitamin K antagonists (VKA) and is considered a strong inhibitor of calcification of arterial vessel wall and cartilage [111]. Warfarin (a VKA) is a risk factor for calcific uremic arteriolopathy, necrotizing skin condition observed in dialysis patients, associated with extremely high mortality rates [11, 112, 113].
