**Acknowledgements**

This work was supported by two doctoral scholarships (88882.447813/2019- 2101 and 88882.447821/2019-2101) financed by CAPES (Coordination for the Improvement of Higher Education Personnel). We thanks the Biotechnology Graduate Program of State University of Feira de Santana (UEFS/FIOCRUZ), Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) and CNPq.
