**Abstract**

Biodegradation is the most viable alternative for numerous health and environmental issues associated with non-biodegradable materials. In recent years, there has been considerable interest in biodegradable nanomaterials due to their relative abundance, environmental benignity, low cost, easy use, and tunable properties. This chapter covers an overview of biodegradation, factors and challenges associated with biodegradation processes, involvement of nanotechnology and nanomaterials in biodegradation, and biodegradable nanomaterials. Furthermore, current chapter extensively discusses the most recent applications of biodegradable nanomaterials that have recently been explored in the areas of food packaging, energy, environmental remediation, and nanomedicine. Overall, this chapter provides a synopsis of how the involvement of nanotechnology would benefit the process of biodegradation.

**Keywords:** Biodegradation, nanoparticles, food packaging, energy storage, environmental remediation, nanomedicine
