*Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms DOI: http://dx.doi.org/10.5772/intechopen.98610*

thirdly, the ability to load drugs that are prone to polymorphic transformation in the present of water or solvent system [33], and finally, the ability to reduces several unit-operations related to traditional manufacturing process such as granulation, milling, sieving, compressing, and coating. Hence, they are very efficient and economical, in particular for small-scale on-demand personalized formulations [34, 35]. Moreover, additive printing technology combines digital design, manufacturing, and controls together, which is an accurate, timesaving, continuous process to meet individual patient needs [28, 36]. Therefore, the combination of HME and additive printing can be applied as a fabrication tool in the field of digital health for the remote manufacture and dispensing of personalized orodispersible dosage forms having shapes, sizes, and doses that are optimized for a particular patient or group of patients based on their needs [28]. Consequently, the therapeutic efficacy and medication adherence can be enhanced owing to the flexibility and autonomy of the treatment process provided by the combination of these technologies.
