**6. Conclusions**

Natural and biodegradable polymers were used increasingly in pharmaceutical formulations, food, and some industrial applications. This chapter has introduced various aspects of alginate metal complexes preparation and its application in organic synthesis, environmental and pharmaceutical fields as a chiral excipient. The latest case involved alginate's ability to build complexes in the presence of multivalent metal. The prepared beads were loaded with racemic profens by an ionotropic method, and the chiral interactions are assumed to affect the drug release due to alginates and profen's chirality, by an in-vitro release in the aqueous solution resembles an intestine medium (6.8–7.4), and the enantioselective release (ESR) was observed in many complexes and differ depending on the alginate-metal complexes type.
