**2. Pharmacokinetics and toxicity of γ- oryzanol**

An experiment carried out by Fujiwara *et al*. revealed that *γ*-oryzanol is readily absorbed by the intestine and is found in high concentrations in the plasma after 1 hour of oral administration [4]. In 2016, Seol-Hee, *et al.* conducted a toxicity study using male and female Sprague–Dawley rats, 1000 and 2000 mg/kg body weight per day were administered to 5 weeks old rats for 90 days. It was observed that the rate of absorption of *γ*- oryzanol was low and most of it was excreted. The study concluded that there were no adverse effects on administration of 1000 and 2000 mg/kg body weight per day of *γ*- oryzanol [5].
