**6. Bioavailability and synergy of anti-NAFLD functional foods**

Low molecular weight anti-NAFLD compounds such as phenolics, terpenes, phytosterols, small carbohydrates and amino acids might be more bioavailable than high and moderately soluble proteins, polypeptides and large carbohydrate molecules. Nonetheless, large molecules such as proteins and carbohydrates have shown a protective effect against NAFLD. In contrast, substances with low molecular weight might help liver regeneration. Combining one or more anti-NAFLD compounds has been shown to result in improved behavior in several studies. Silybin treatment, in combination with vitamin E and phosphatidylcholine, significantly improved liver enzymes and liver steatosis in NAFLD patients [119]. Another study by Han et al. showed metformin (500 mg orally three times daily) in combination with vitamin E (100 mg) and bicyclol (25 mg) synergistically prevented NAFLD in human subjects by improving liver enzymes and liver histology parameters. The combination of blueberry juice and probiotics 1.5 mL per 100 g (0.07 mg/mL concentration) weight showed protection to hepatocyte mitochondrial function in the HFD induced animals [120].
