**2.10 Convalescent plasma therapy**

Convalescent plasma is obtained from donors who have recovered from covid-19 infection, possess antibodies against SARS-CoV-2 that may neutralize the virus and modify the immune response [74]. Convalescent plasma therapy offers short term protection strategy and generates immediate immune response in susceptible patients. This approach has already been used in earlier outbreak of corona viruses such as SARS and MERS [75]. In this corona pandemic, many clinical trials have also been conducted against SARS-CoV-2. Recently the clinical study conducted by Duan et al. [76] revealed that the convalescent plasma therapy was well tolerated and positively improved the clinical outcomes in severe covid-19 patients. Salazar et al. [77] reported the use of convalescent plasma therapy in 25 patients who had severe covid-19 disease and evaluated safety along with clinical outcomes at 14 day after the transfusion. They found clinical improvement in nine patients within seven days and other were discharged at day 14. Hence, convalescent plasma therapy has potential to treat covid-19 cases but some adverse events have also been reported such as allergic reaction, dyspnoea and acute lung injury [78] (**Figure 1**).
