**3. Structural insights of potential SARS-CoV-2 proteins**

The structural research was initiated by studying in silico modeling Wuhan-Hu1 market seafood pneumonia virus genome [14, 15]. Focused on reported studies on SARS-CoV-2, we highlighted the number of nsp structures of this virus available: the papain-like protease (PLpro, nsp3; PDB code: 7D47), the main protease (3CLpro, nsp5; PDB code: 6LZE), the RNA-dependent RNA polymerase (RdRp, nsp12) in complex with cofactors nsp7 and nsp8 (PDB code: 6M71), the helicase (nsp 13; PDB code: 6ZSL), the Spike glycoprotein (S)(PDB code: 6XR8) and the RNA binding domain of nucleocapsid (N) phosphoprotein (PDB code: 6VYO).
