**2.11 Ivermectin**

Ivermectin is an broad spectrum antiparasitic drug and its antiviral activity has also been reported against number of viruses both *in vitro* and *in vivo* [79]. Recently, *in vitro* study revealed that ivermectin can inhibit SARS-CoV-2 replication by reducing viral RNA up to 5000 fold at 48 h. in culture cells [80]. However, the mechanism of action of ivermectin is not clearly known. Choudhry and Sharma, [81] have mentioned that ivermectin may act by creating acidic environment and blocking the importin IMP2/β1 mediated viral intranuclear import (**Figure 1**).
