**1. Introduction**

The World Health Organization (WHO) confirmed that the infection of SARS-CoV-2 could transfer from human to human via the airway droplet spread, infected surfaces, or fecal route [1–3]. SARS-CoV-2 causes COVID-19 respiratory disease belonging to β-CoV (lineage B) with a duration of 3–6 days [4]. Seah et al. [5] reported that coronaviruses (CoVs) consist of nucleocapsid protein (N) for bounding to RNA genome to make up nucleocapsid, spike protein (S) for binding of host cell receptors to facilitate entry of host cell, an envelope protein (E) for interacting with M to form a viral envelope, and membrane protein (M) for the central organizer of CoV assembly and determining the shape of the viral envelope. SARS-CoV-2 is dissimilar to SARS-CoV in the absence of 8a, longer 8b, and shorter 3b segments and different in the presence of Nsp 2, Nsp3, open reading frame (orf) 2,

