**4. Targeting monocytes and macrophages**

Targeting monocytes and macrophages as a strategy to improve outcomes in people infected with SARS-CoV-2 has been an area of considerable interest since the beginning of the COVID-19 pandemic. As key effectors of the innate immune system, they play an important role orchestrating the immune response to SARS-CoV-2. This approach has been primarily focused on systemic anti-inflammatories, although a number of other strategies are under investigation. While a variety of small molecule and biologic based strategies have been investigated to treat COVID-19, there has been a relative dearth of strategies which have been shown to improve disease outcomes.
