**7. Conclusion**

The current pandemic we are encountering has placed an unprecedented burden upon the world and is likely to leave an everlasting impact for generations to come. With the lack of definitive and safe treatment along with the congruent rise in unknown viral variants the demand for a safe source of mitigation is urgently needed. Clincial studies have specified tht patients who suffer from SARS-CoV-2 related ARDS have an indued cytokine storm composed of a large and rapid surge in pro-inflammatory cytokines and inflammatory cells. MSCs and their EVs have a long been touted for their safty and effectiveness in the treatment of immune related diseases, ALI and ARDS. MSCs and EVs have are now being repourposed for COVID-19 due to their antiviral, anti-inflammatory and tissue regenerative capabilities. Data from clinical trials using MSCs and EVs have shown promising results that warrant their use on a compassionate basis for COVID-19. Eventually more pre-clinical and clinical trials are needed to further establish the safety and efficacy of MSCs and their EVs as a potential treatment for COVID-19.
