**Abstract**

This chapter reviews various methods of cannery wastewater biological treatment, namely up-flow anaerobic sludge blanket (UASB), sequencing batch reactor (SBR), three-stage aerobic rotating biological contactor (RBC), three sequentially arranged reactors (anaerobic-anoxic-aerobic reactors), lagooning, and anaerobic digestion. The general principles for dealing with the uncertainty of general wastewater treatment plants are applied to control the uncertainty in cannery wastewater treatment. An overview of on the application of Monte Carlo, support vector machine (SVM), artificial neural network (ANN), and genetic algorithm to manage the uncertainty in the biological treatment of wastewater is provided.

**Keywords:** cannery wastes, up-flow anaerobic sludge blanket, anaerobic digestion, sequencing batch reactor, three-stage aerobic rotating biological contactor, uncertainty in wastewater treatment
