**Abstract**

In this Chapter, an overview of health security in different regions of the world will be considered with emphasis on the situation in low resource settings such as the global south and Asia since they share a lot in common. Additionally, how countries in these areas, especially sub-Saharan Africa, used existing health infrastructure, local resources and policy to somehow successfully (at least, presently) combat the ongoing COVID-19 pandemic will be elucidated. Ways in which the current approach being adopted by these countries could be used to fight other emerging health conditions such as rising cases of cardiovascular and chronic conditions in these countries will be considered in this Chapter. These measures may boost and ensure sustainability of overall healthcare capacities of these countries.

**Keywords:** international health security, COVID-19, emerging health threats, low-resource settings, healthcare
