**Abstract**

This chapter delves into the relatively new DNA technique of probabilistic genotyping, which aims to a more precise determination of complex DNA profiles of multiple contributors. It explains the forensic value of this methodology compared to traditional DNA techniques such as Combined Probability of Inclusion (CPI). In particular, this forensic value is demonstrated in light of the reversal of several wrongful convictions in the USA and Europe. Apart from having a potential exculpatory effect, the advance of probabilistic genotyping can also contribute to discerning the real perpetrator of a crime. As a result, this chapter emphasizes the relevance of probabilistic genotyping for both defense lawyers and prosecutors in criminal cases.

**Keywords:** Mark Perlin, Greg Hampikian, DNA evidence, forensic evidence, probabilistic genotyping, DNA mixtures, wrongful convictions, defense lawyers, prosecutors, Lydell Grant, Dutch Proveniers case
